Cansu Dinçer
@cansudincer.bsky.social
Postdoc at University of Oxford-WIMM @imm.ox.ac.uk
Computational Biologist #cancer
Computational Biologist #cancer
If you are fancy to test, please check the below repository:
📂 GitHub: github.com/CansuDincer/...
📂 GitHub: github.com/CansuDincer/...
GitHub - CansuDincer/BEstimate: BEstimate, a Python module that systematically analyses guide RNA (gRNA) targetable sites across given sequences for given Base Editors, and functional and clinical eff...
BEstimate, a Python module that systematically analyses guide RNA (gRNA) targetable sites across given sequences for given Base Editors, and functional and clinical effects of the potential edits o...
github.com
May 22, 2025 at 1:21 PM
If you are fancy to test, please check the below repository:
📂 GitHub: github.com/CansuDincer/...
📂 GitHub: github.com/CansuDincer/...
BEstimate enables the identification of gRNAs, generating variants on reference and mutant sequences, correcting pathogenic variants for therapeutic development, and extensive annotation of the base editing libraries for pre- and post-experiment interpretation.
May 22, 2025 at 1:21 PM
BEstimate enables the identification of gRNAs, generating variants on reference and mutant sequences, correcting pathogenic variants for therapeutic development, and extensive annotation of the base editing libraries for pre- and post-experiment interpretation.
In this preprint, we highlighted its utility in different cases:
🧬 Design gRNA libraries for reference and cell line-specific sequences, leveraging SNP-aware mode
🩸 Identify gRNAs that revert pathogenic variants
🔍 Comprehensively annotate a MYC base editing screen
🧬 Design gRNA libraries for reference and cell line-specific sequences, leveraging SNP-aware mode
🩸 Identify gRNAs that revert pathogenic variants
🔍 Comprehensively annotate a MYC base editing screen
May 22, 2025 at 1:21 PM
In this preprint, we highlighted its utility in different cases:
🧬 Design gRNA libraries for reference and cell line-specific sequences, leveraging SNP-aware mode
🩸 Identify gRNAs that revert pathogenic variants
🔍 Comprehensively annotate a MYC base editing screen
🧬 Design gRNA libraries for reference and cell line-specific sequences, leveraging SNP-aware mode
🩸 Identify gRNAs that revert pathogenic variants
🔍 Comprehensively annotate a MYC base editing screen
With BEstimate you can:
✅ Fully customise Cas enzymes, base editors & PAMs
✅ Design libraries for reference or mutated sequences
✅ Find gRNAs reverting the alterations
✅ Annotate functional, structural & clinical impacts
✅ Retrieve real-time data via Ensembl & UniProt APIs
✅ Fully customise Cas enzymes, base editors & PAMs
✅ Design libraries for reference or mutated sequences
✅ Find gRNAs reverting the alterations
✅ Annotate functional, structural & clinical impacts
✅ Retrieve real-time data via Ensembl & UniProt APIs
May 22, 2025 at 1:21 PM
With BEstimate you can:
✅ Fully customise Cas enzymes, base editors & PAMs
✅ Design libraries for reference or mutated sequences
✅ Find gRNAs reverting the alterations
✅ Annotate functional, structural & clinical impacts
✅ Retrieve real-time data via Ensembl & UniProt APIs
✅ Fully customise Cas enzymes, base editors & PAMs
✅ Design libraries for reference or mutated sequences
✅ Find gRNAs reverting the alterations
✅ Annotate functional, structural & clinical impacts
✅ Retrieve real-time data via Ensembl & UniProt APIs
Huge thanks to Downing College and the fantastic organising committee for putting together such a thoughtful and stimulating event. I’m honoured by the recognition and thankful for the opportunity to present my research!
May 13, 2025 at 2:59 PM
Huge thanks to Downing College and the fantastic organising committee for putting together such a thoughtful and stimulating event. I’m honoured by the recognition and thankful for the opportunity to present my research!
I’d like to share my gratitude for my examiners @ciccarellilab.bsky.social and Oscar Rueda for making my viva such an informative and intellectually stimulative discussion.
December 13, 2024 at 11:56 AM
I’d like to share my gratitude for my examiners @ciccarellilab.bsky.social and Oscar Rueda for making my viva such an informative and intellectually stimulative discussion.