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cameo3d.org
CAMEO-3D
@cameo3d.org
24 followers 1 following 10 posts
https://www.cameo3d.org/

CAMEO (Continuous Automated Model EvalutatiOn) is a community project to continuously evaluate the accuracy and reliability of 3D complex structure predictions.

Developed by @sib.swiss and @biozentrum.unibas.ch.
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cameo3d.org
Runs N' Poses is a great example of how to rigorously filter protein–ligand complexes for structural similarity: www.biorxiv.org/content/10.1....
Figure 4 in the Runs N' Poses paper shows how one can combine sequence identity with ligand similarity metrics to assess the structural novelty of protein-ligand complexes.
August 8, 2025 at 7:48 AM
cameo3d.org
Filtering out homologous structures from the PDB at 40% sequence identity is not enough to create a robust test set. Significant leakage persists at this level, and comparative modeling can still produce high quality models.
Scatter plot of LDDT as a function of sequence identity for high coverage homology models. The horizontal red line at 40% sequence identity highlights the presence high quality models in the low sequence identity region.
August 8, 2025 at 7:48 AM
cameo3d.org
Create your account and register your server now!
cameo3d.org
The "Create a new server" button
April 28, 2025 at 8:00 AM
cameo3d.org
Detailed per-target scores and interactive 3D visualization.
The target page with server results and superposed 3D structures.
April 28, 2025 at 7:56 AM
cameo3d.org
Custom timeframes, automatic server comparisons on shared targets, multi-metric evaluations, and interactive boxplots for selected servers.
The CAMEO results page with custom timeframes, common subset comparison, and boxplots
April 28, 2025 at 7:56 AM
cameo3d.org
Introducing CAMEO Structures & Complexes - automated weekly blind benchmarking of structure prediction servers. Now with heteromeric and protein-ligand complexes.
Join us and register your server now!
cameo3d.org
April 28, 2025 at 7:56 AM