@brandon-beaber.bsky.social
Basketball YouTube Star Tristan Jass announces he will have brain surgery for a right temporal lobe cyst discovered in 2019 after a seizure. This cyst slowly grew over 6 years and had a small enhancing component on a 2025 MRI, so surgery was recommended. youtu.be/UUPt35etmAQ?...
December 8, 2025 at 5:39 AM
Basketball YouTube Star Tristan Jass announces he will have brain surgery for a right temporal lobe cyst discovered in 2019 after a seizure. This cyst slowly grew over 6 years and had a small enhancing component on a 2025 MRI, so surgery was recommended. youtu.be/UUPt35etmAQ?...
Neurologist Explains Nate the Lawyer's Brain Tumor youtu.be/HrEKZoLkE34?...
November 26, 2025 at 4:33 PM
Neurologist Explains Nate the Lawyer's Brain Tumor youtu.be/HrEKZoLkE34?...
This is a case report of 30 year old woman taking ocrevus for multiple sclerosis who developed fever, double vision, difficulty swallowing, weakness who was found to have rhombencephalitis caused by human herpesvirus 6 (HHV-6) (very rare complication) pubmed.ncbi.nlm.nih.gov/41284955/
November 25, 2025 at 6:47 PM
This is a case report of 30 year old woman taking ocrevus for multiple sclerosis who developed fever, double vision, difficulty swallowing, weakness who was found to have rhombencephalitis caused by human herpesvirus 6 (HHV-6) (very rare complication) pubmed.ncbi.nlm.nih.gov/41284955/
Epstein-Barr virus causes MS, so everyone with MS has antibodies against EBV. OH REALLY? This study in Sri Lanka found "only" 96.3% of people with MS have antibodies (vs. 86.5% of controls) pubmed.ncbi.nlm.nih.gov/41270350/
November 24, 2025 at 10:56 PM
Epstein-Barr virus causes MS, so everyone with MS has antibodies against EBV. OH REALLY? This study in Sri Lanka found "only" 96.3% of people with MS have antibodies (vs. 86.5% of controls) pubmed.ncbi.nlm.nih.gov/41270350/
The κ-FLC index, though a useful spinal tap test to diagnose MS and is an alternative to oligoclonal bands, did not correlate at all with prognosis (top image) in the study in primary progressive multiple sclerosis pubmed.ncbi.nlm.nih.gov/41280940/
November 24, 2025 at 10:49 PM
The κ-FLC index, though a useful spinal tap test to diagnose MS and is an alternative to oligoclonal bands, did not correlate at all with prognosis (top image) in the study in primary progressive multiple sclerosis pubmed.ncbi.nlm.nih.gov/41280940/
12 year old girl diagnosed with tonsilitis at age 3 and later anti-GAD limbic encephalitis, thyroiditis, type 1 diabetes, celiac disease. Father with "multiple sclerosis." Skin biopsy (Protein Gene Product 9.5 marker, magnification 10X (a) and 20X (b)) showed this! Diagnosis?
November 20, 2025 at 10:54 PM
12 year old girl diagnosed with tonsilitis at age 3 and later anti-GAD limbic encephalitis, thyroiditis, type 1 diabetes, celiac disease. Father with "multiple sclerosis." Skin biopsy (Protein Gene Product 9.5 marker, magnification 10X (a) and 20X (b)) showed this! Diagnosis?
spinal Leptomeningeal enhancement can be a feature of Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), especially in children. www.neurology.org/doi/10.1212/...
November 20, 2025 at 10:46 PM
spinal Leptomeningeal enhancement can be a feature of Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), especially in children. www.neurology.org/doi/10.1212/...
subcutaneous tysabri is coming for people with MS. this small observational study (n = 63) with 300mg found very low rates of relapses (0.03 per person per year), new MRI lesions. pubmed.ncbi.nlm.nih.gov/41260150/
November 20, 2025 at 9:34 PM
subcutaneous tysabri is coming for people with MS. this small observational study (n = 63) with 300mg found very low rates of relapses (0.03 per person per year), new MRI lesions. pubmed.ncbi.nlm.nih.gov/41260150/
Are these MRI findings in people with multiple sclerosis? Shockingly, NO! They actually have Wolfram syndrome (WFS), a rare genetic disorder associated with pathogenic variants in WFS1 and is linked to optic atrophy, hearing loss and diabetes. www.frontiersin.org/journals/neu...
November 18, 2025 at 3:59 AM
Are these MRI findings in people with multiple sclerosis? Shockingly, NO! They actually have Wolfram syndrome (WFS), a rare genetic disorder associated with pathogenic variants in WFS1 and is linked to optic atrophy, hearing loss and diabetes. www.frontiersin.org/journals/neu...
Paramagnetic rim lesions in multiple sclerosis (which appear dark on SWI sequence and are often periventricular) are associated with nearly triple the risk of disability progression (OR 2.87; 95 % CI: 1.01–8.1; p = 0.05) pubmed.ncbi.nlm.nih.gov/41205558/
November 12, 2025 at 10:34 PM
Paramagnetic rim lesions in multiple sclerosis (which appear dark on SWI sequence and are often periventricular) are associated with nearly triple the risk of disability progression (OR 2.87; 95 % CI: 1.01–8.1; p = 0.05) pubmed.ncbi.nlm.nih.gov/41205558/
A summary of the 2024 McDonald Diagnostic Criteria for Multiple Sclerosis. jamanetwork.com/journals/jam...
November 12, 2025 at 10:28 PM
A summary of the 2024 McDonald Diagnostic Criteria for Multiple Sclerosis. jamanetwork.com/journals/jam...
The "cascade" (waterfall) sign on coronal images on MRI can be see with multiple sclerosis (image 1), myelin oligodendrocyte glycoprotein associated disease (image 2), glioma (image 3), and behcet's disease (image 5) journals.lww.com/neur/fulltex...
November 12, 2025 at 10:25 PM
The "cascade" (waterfall) sign on coronal images on MRI can be see with multiple sclerosis (image 1), myelin oligodendrocyte glycoprotein associated disease (image 2), glioma (image 3), and behcet's disease (image 5) journals.lww.com/neur/fulltex...
The target of various multiple sclerosis drugs. (OCR = ocrevus, INF = interferon, NTZ = tysabri, FTY = gilenya, CLAD = cladribine, ALEM = Lemtrada, GA = copaxone, SPN = Mayzent, OZN = zeposia, PON = Ponvory, TF = tecfidera, MMF = bafiertam) onlinelibrary.wiley.com/doi/10.1111/...
November 12, 2025 at 10:22 PM
The target of various multiple sclerosis drugs. (OCR = ocrevus, INF = interferon, NTZ = tysabri, FTY = gilenya, CLAD = cladribine, ALEM = Lemtrada, GA = copaxone, SPN = Mayzent, OZN = zeposia, PON = Ponvory, TF = tecfidera, MMF = bafiertam) onlinelibrary.wiley.com/doi/10.1111/...
Multiple sclerosis is generally speaking less heritable than many other neurological diseases. pmc.ncbi.nlm.nih.gov/articles/PMC...
November 10, 2025 at 7:02 AM
Multiple sclerosis is generally speaking less heritable than many other neurological diseases. pmc.ncbi.nlm.nih.gov/articles/PMC...
Can you switch from Ocrevus or rituximab to Kesimpta for MS. Yes. In this phase 3b (unrandomized) trial (OLIKOS study), changing to kesimpta was linked to a low rate of new MRI lesions (2.3% with new/enlarging lesions) and relapses (0.075 per year). pubmed.ncbi.nlm.nih.gov/41196386/
November 10, 2025 at 6:57 AM
Can you switch from Ocrevus or rituximab to Kesimpta for MS. Yes. In this phase 3b (unrandomized) trial (OLIKOS study), changing to kesimpta was linked to a low rate of new MRI lesions (2.3% with new/enlarging lesions) and relapses (0.075 per year). pubmed.ncbi.nlm.nih.gov/41196386/
Do carbs cause MS? This study from England found a slight association between higher carbohydrate intake and risk of MS (a 21% increase per quartile of increased consumption) pmc.ncbi.nlm.nih.gov/articles/PMC...
October 27, 2025 at 3:10 AM
Do carbs cause MS? This study from England found a slight association between higher carbohydrate intake and risk of MS (a 21% increase per quartile of increased consumption) pmc.ncbi.nlm.nih.gov/articles/PMC...
Do medications for alzheimer's disease work for people with MS with cognitive impairment? Probably not. The data for Namenda and cholinesterase inhibitors is bad. There is some positive data on stimulants. Image is Symbol digits modalities test. pmc.ncbi.nlm.nih.gov/articles/PMC...
October 27, 2025 at 3:09 AM
Do medications for alzheimer's disease work for people with MS with cognitive impairment? Probably not. The data for Namenda and cholinesterase inhibitors is bad. There is some positive data on stimulants. Image is Symbol digits modalities test. pmc.ncbi.nlm.nih.gov/articles/PMC...
61 year old Italian man with progressive MS was started on zeposia and developed this [asymptomatic] abnormality on screening ocular computed tomography (OCT). Diagnosis?
October 27, 2025 at 2:57 AM
61 year old Italian man with progressive MS was started on zeposia and developed this [asymptomatic] abnormality on screening ocular computed tomography (OCT). Diagnosis?
A summary of the efficacy of ublituximab (briumvi) on prevention of relapses and MRI activity in multiple sclerosis (data from the ULTIMATE I/II trials) pmc.ncbi.nlm.nih.gov/articles/PMC...
October 21, 2025 at 4:10 AM
A summary of the efficacy of ublituximab (briumvi) on prevention of relapses and MRI activity in multiple sclerosis (data from the ULTIMATE I/II trials) pmc.ncbi.nlm.nih.gov/articles/PMC...
Which YouTube Thumbnail do you prefer?
October 19, 2025 at 4:08 PM
Which YouTube Thumbnail do you prefer?
The effect on brain atrophy of different MS disease modifying therapies based on a network meta-analysis (click the image) pubmed.ncbi.nlm.nih.gov/41080911/
October 14, 2025 at 4:38 AM
The effect on brain atrophy of different MS disease modifying therapies based on a network meta-analysis (click the image) pubmed.ncbi.nlm.nih.gov/41080911/
People with higher income with multiple sclerosis in New Zeland were more likely to receive highly effective disease modifying therapy. pubmed.ncbi.nlm.nih.gov/41072254/
October 13, 2025 at 6:02 AM
People with higher income with multiple sclerosis in New Zeland were more likely to receive highly effective disease modifying therapy. pubmed.ncbi.nlm.nih.gov/41072254/
A thumbnail created by me (left) vs. chat gpt (right). Which do you prefer?
October 11, 2025 at 10:11 PM
A thumbnail created by me (left) vs. chat gpt (right). Which do you prefer?
14.3 % of people with MS have paramagnetic rim lesions (PRLs) (dark rim on SWI sequence) which correlate with higher disability [data from Norway] pmc.ncbi.nlm.nih.gov/articles/PMC...
October 9, 2025 at 3:19 AM
14.3 % of people with MS have paramagnetic rim lesions (PRLs) (dark rim on SWI sequence) which correlate with higher disability [data from Norway] pmc.ncbi.nlm.nih.gov/articles/PMC...
The published MS-STAT2 trial, a phase 3, randomized, double-blind, placebo-controlled trial which DID NOT show any benefit of high dose simvastatin in preventing disability progression in progressive MS. pubmed.ncbi.nlm.nih.gov/41045938/
October 6, 2025 at 5:28 AM
The published MS-STAT2 trial, a phase 3, randomized, double-blind, placebo-controlled trial which DID NOT show any benefit of high dose simvastatin in preventing disability progression in progressive MS. pubmed.ncbi.nlm.nih.gov/41045938/