Ayshwarya Subramanian
@ayshwaryas.bsky.social
Assistant Professor at the Department of Molecular Biology and Genetics at Cornell University
https://www.cellhomology.space/
https://www.cellhomology.space/
Our study implicates Tim3 in tuning microglial state along the inflammatory spectrum with its deficiency potentially beneficial in AD. We are excited about the broader potential of this finding in AD models and human data. Read more @mgbresearch.bsky.social /n
Potential Alzheimer’s Disease Therapeutic Target Identified in Brain Immune Cells | Mass General Brigham
Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer’s disease, but its role in the brain was unknown until now.
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April 10, 2025 at 3:39 AM
Our study implicates Tim3 in tuning microglial state along the inflammatory spectrum with its deficiency potentially beneficial in AD. We are excited about the broader potential of this finding in AD models and human data. Read more @mgbresearch.bsky.social /n
Tim3 deficient 5XFAD mice had a reduced plaque load and improved cognitive function. By sc & snRNAseq analysis, we found that 5XFAD microglia deficient in Tim3 acquire a more phagocytic and anti-inflammatory state. 4/
April 10, 2025 at 3:39 AM
Tim3 deficient 5XFAD mice had a reduced plaque load and improved cognitive function. By sc & snRNAseq analysis, we found that 5XFAD microglia deficient in Tim3 acquire a more phagocytic and anti-inflammatory state. 4/
We found that Tim3 regulates microglial activity via TGFb signaling. AD is characterized by buildup of amyloid beta plaques & neurofibrillary tangles with reduced cognitive function. We deleted Havcr2 in the microglia of 5XFAD mice, a common AD disease model with AB plaques. 3/
April 10, 2025 at 3:39 AM
We found that Tim3 regulates microglial activity via TGFb signaling. AD is characterized by buildup of amyloid beta plaques & neurofibrillary tangles with reduced cognitive function. We deleted Havcr2 in the microglia of 5XFAD mice, a common AD disease model with AB plaques. 3/
HAVCR2(gene)/TIM3(protein) is a known T cell immune checkpoint implicated in multiple cancers with active clinical trials. But HAVCR2 is also a GWAS risk gene for AD. In the mouse and human brain, HAVCR2 is highly expressed in microglia, the resident immune cells 2/
April 10, 2025 at 3:39 AM
HAVCR2(gene)/TIM3(protein) is a known T cell immune checkpoint implicated in multiple cancers with active clinical trials. But HAVCR2 is also a GWAS risk gene for AD. In the mouse and human brain, HAVCR2 is highly expressed in microglia, the resident immune cells 2/
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April 5, 2025 at 2:34 PM
Thank you for organizing and sharing this event. Is zoom attendance an option?