Aya Ludin
@ayaludin.bsky.social
Post doc fellow, Zon lab, Harvard. PhD, Weizmann Institute, Israel. A firm believer that the zebrafish natural habitat is under a very good microscope.
Pinned
Aya Ludin
@ayaludin.bsky.social
· Oct 18
🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social.
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
👇And happy Thanksgiving everyone!
The new issue is out 👉 www.cell.com/cell/current
On the cover: Ludin et al. identify antigen-rich tumor niches, CRATERs, on the solid tumor surface, which facilitate CD8+ T cell-tumor interactions and tumor killing.
On the cover: Ludin et al. identify antigen-rich tumor niches, CRATERs, on the solid tumor surface, which facilitate CD8+ T cell-tumor interactions and tumor killing.
November 27, 2025 at 3:06 PM
👇And happy Thanksgiving everyone!
CRATERs on Cover! Thanks @cp-cell.bsky.social for choosing our study for the cover of the Nov 26th issue! A beautiful illustration by @maayanvisuals.bsky.social and @mgarbelli.bsky.social depicting CD8+ T cells descend into CRATERs on a melanoma, where they will engage with the tumor and kill it.
November 26, 2025 at 4:38 PM
CRATERs on Cover! Thanks @cp-cell.bsky.social for choosing our study for the cover of the Nov 26th issue! A beautiful illustration by @maayanvisuals.bsky.social and @mgarbelli.bsky.social depicting CD8+ T cells descend into CRATERs on a melanoma, where they will engage with the tumor and kill it.
Reposted by Aya Ludin
CRATERs have been identified as sites of increased tumor antigen presentation where T cells can recognize and kill tumor cells bit.ly/3J8g42v @ayaludin.bsky.social
October 29, 2025 at 4:45 PM
CRATERs have been identified as sites of increased tumor antigen presentation where T cells can recognize and kill tumor cells bit.ly/3J8g42v @ayaludin.bsky.social
Reposted by Aya Ludin
🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social.
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
October 18, 2025 at 5:46 PM
🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social.
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
That's true! We had to develop quite a bit of new technology to be able to see what we report (big thanks to @asaftal.bsky.social !). Thank you, Yi!
Timely and important👇zebrafish cancer models provide unprecedented mechanistic insights on immune-cancer interaction 👏👏👏 solid work takes years to mature!!!
🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social.
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
October 19, 2025 at 7:20 PM
That's true! We had to develop quite a bit of new technology to be able to see what we report (big thanks to @asaftal.bsky.social !). Thank you, Yi!
🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social.
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
October 18, 2025 at 5:46 PM
🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social.
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
Reposted by Aya Ludin
Now online! CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success
CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success
CD8+ T cells preferentially engage tumor cells in pockets termed CRATERs, which are rich with antigen presentation molecules and breach into the tumor mass from the stromal compartment. CRATERs expand and become the major site of tumor killing during immune-stimulatory treatment, and their expansion parallels clinical benefit in patients undergoing immunotherapy.
dlvr.it
October 17, 2025 at 2:59 PM
Now online! CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success