Reminding me of the strategic error I made when camping in the negatives of letting my water bottle roll away from me in the night. No tea in the morning, but I had much better gear, so was not otherwise cold!

I thought it accepted anion last week, but not anionic?
I live in eternal hope it will accept PINNA.

have found there have been all kinds of developments in the area since I last thought of one. Being hyperfocused in a couple of areas means we lose sight of a lot of things..... but now maybe I should update my lecture notes on such reductions. (6/6)

Another was today, where I set up a reaction with our dwindling supply of something purchased a few years ago at great cost, only to discover it's now available in a 500 g bottle, for less than $200. Now I find myself reading the literature on phosphine oxide reductions, and (5/n)

One was very early on in my independent career, when I had the notion that B2(pin)2 was very expensive, and I suggested finding a way to catalytically make it was a good research goal during a committee meeting (it's actually so cheap that the system we were looking at would have been pointless)4/n

absolutely floored when somebody pulled out a catalogue and showed them the price. That bias they had almost certainly led to them either not using it, or trying to come up with alternatives, when it would have been perfectly accessible. I've had a few moments myself like that (3/n)

the early days of my PhD, having a chat with a very very esteemed researcher (not a faculty member at my grad school), and something about binap or binol came up. They had the idea in their head that it was 1000s of dollars per gram enantiopure, and they were (2/n)

synthesis came out first, leading to essentially the need to cite the methods paper on the auxiliary that was not yet available. I can't exactly remember how they phrased it, but likely something similar! (2/2)

I remember one of my friends working on a project to make a new chiral auxiliary. The PI gave out the auxiliary to one of his former students, who was a PI at a different institution, who then used it in a total synthesis. Both papers were submitted around the same time, but the total (1/n)

We considered that, but I think the DMSO is just a good solvent. We did the "control reaction" without HEH, with Cs2CO3 in DMSO, and there was no fluoride formed. DMPU is on the "to do list" somewhere. We are aware of the hazards of hydride bases in DMSO, so scaling is not on our radar there!

Not sure if it's fair to apply the "it's not even wrong" comment from Pauli to the output of a machine, but that's pretty bad.

I inherited one from who knows when, when I started as a prof over 10 years ago. It has sat on my desk, and floor after I switched offices, uncomplainingly printing on demand, on a very irregular schedule. It interfaces with whatever computer I ask it to, always seamlessly.

I was trying "BELLBOTTOM" for far too long!

Yeah, it's funny when they take a particular alkane, but not another one. But I always miss things like IONIC, or NEON.