Audrey Leprince
@aulep15.bsky.social
Microbiologist studying phage-host interactions
Postdoc at Université Laval (Québec) in Sylvain Moineau's Lab
Postdoc at Université Laval (Québec) in Sylvain Moineau's Lab
Reposted by Audrey Leprince
KlebPhaCol paper is now out! Go check it out and see all that we offer.
And when ready, visit our website for more: www.klebphacol.org
And when ready, visit our website for more: www.klebphacol.org
November 22, 2025 at 6:19 PM
KlebPhaCol paper is now out! Go check it out and see all that we offer.
And when ready, visit our website for more: www.klebphacol.org
And when ready, visit our website for more: www.klebphacol.org
Reposted by Audrey Leprince
Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites
Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses
phage attachment at the membrane and assembles a transmembrane complex that halts
infection by blocking phage DNA re...
www.cell.com
July 28, 2025 at 7:43 PM
Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
Reposted by Audrey Leprince
Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...
July 23, 2025 at 7:35 AM
Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...
Reposted by Audrey Leprince
ICYMI: CRISPR–Cas therapies targeting bacteria
CRISPR–Cas therapies targeting bacteria
Nature Reviews Bioengineering, Published online: 13 May 2025; doi:10.1038/s44222-025-00311-8CRISPR–Cas tools can be designed to kill or modify specific bacteria. This Review explores the engineering of CRISPR–Cas tools and corresponding delivery strategies for the treatment of bacterial infections and modification of the microbiome.
www.nature.com
May 15, 2025 at 6:53 AM
Reposted by Audrey Leprince
Our paper on how integrons are biobanks of novel minimal defense systems is now out www.science.org/doi/10.1126/... Two main conclusions on this excellent work led by @eloilittner.bsky.social @baptistedarracq.bsky.social 1/n
May 9, 2025 at 1:07 PM
Our paper on how integrons are biobanks of novel minimal defense systems is now out www.science.org/doi/10.1126/... Two main conclusions on this excellent work led by @eloilittner.bsky.social @baptistedarracq.bsky.social 1/n
Reposted by Audrey Leprince
Check out our latest Science Story "NMDC Community members put mobile metadata management to the test" featuring 2023 Ambassador and Champion Thomas Pitot and how his field experiences contributed to the development of our newly released Field Notes mobile app! microbiomedata.org/2025/04/28/n...
April 30, 2025 at 3:37 PM
Check out our latest Science Story "NMDC Community members put mobile metadata management to the test" featuring 2023 Ambassador and Champion Thomas Pitot and how his field experiences contributed to the development of our newly released Field Notes mobile app! microbiomedata.org/2025/04/28/n...
Reposted by Audrey Leprince
New version of DefenseFinder available defensefinder.mdmlab.fr (& cli)
Now encompassing 263 systems (+111 this year..!).
Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models
Now encompassing 263 systems (+111 this year..!).
Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models
Webservice | DefenseFinder webservice and knowledge base
On this site, you can freely use (without any login) the DefenseFinder webservice (see below) and get help to navigate the ever expanding world of defense systems.There is a collaborative knowledge ba...
defensefinder.mdmlab.fr
February 19, 2025 at 4:28 AM
New version of DefenseFinder available defensefinder.mdmlab.fr (& cli)
Now encompassing 263 systems (+111 this year..!).
Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models
Now encompassing 263 systems (+111 this year..!).
Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models
Reposted by Audrey Leprince
Check out our latest #phagetherapy review in Nature Reviews Methods Primers.
rdcu.be/d9H92
Happy to share a conceptual schematic for a “phrinter (phage printer)” 😊
Many thanks to all co-authors, editors and reviewers!
rdcu.be/d9H92
Happy to share a conceptual schematic for a “phrinter (phage printer)” 😊
Many thanks to all co-authors, editors and reviewers!
February 17, 2025 at 3:01 PM
Check out our latest #phagetherapy review in Nature Reviews Methods Primers.
rdcu.be/d9H92
Happy to share a conceptual schematic for a “phrinter (phage printer)” 😊
Many thanks to all co-authors, editors and reviewers!
rdcu.be/d9H92
Happy to share a conceptual schematic for a “phrinter (phage printer)” 😊
Many thanks to all co-authors, editors and reviewers!
Reposted by Audrey Leprince
🧬 Save the date! The EMBO Workshop "The Immune System of Bacteria" will uncover groundbreaking insights into bacterial defense systems. Join us April 8-10, 2025, at Institut Pasteur, Paris. Submit your abstracts by Feb. 28 👉 https://www.sisb2025.conferences-pasteur.org/home
January 16, 2025 at 8:45 PM
Reposted by Audrey Leprince
What is the diversity of antiphage systems out there ?
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
January 9, 2025 at 1:18 PM
What is the diversity of antiphage systems out there ?
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
Reposted by Audrey Leprince
Beautiful work by Thomas Pitot as well as by @simrouxvirus.bsky.social, @ai-cy.bsky.social, @vincentsomerville.bsky.social, et al. !
academic.oup.com/ismecommun/a...
academic.oup.com/ismecommun/a...
Viral niche-partitioning: Comparative genomics of giant viruses across environmental gradients in a High Arctic freshwater-saltwater lake
Abstract. Giant viruses (GVs; Nucleocytoviricota) impact the biology and ecology of a wide range of eukaryotic hosts, with implications for global biogeoch
academic.oup.com
December 16, 2024 at 5:04 PM
Beautiful work by Thomas Pitot as well as by @simrouxvirus.bsky.social, @ai-cy.bsky.social, @vincentsomerville.bsky.social, et al. !
academic.oup.com/ismecommun/a...
academic.oup.com/ismecommun/a...
Reposted by Audrey Leprince
Sadly, it’s a good time to once again share this amazing infographic that we ran at @science.org more than 7 years ago
🧪 #IDsky
www.science.org/content/arti...
🧪 #IDsky
www.science.org/content/arti...
Here's the visual proof of why vaccines do more good than harm
See year by year how vaccines beat back nine dangerous infectious diseases
www.science.org
December 14, 2024 at 9:10 PM
Sadly, it’s a good time to once again share this amazing infographic that we ran at @science.org more than 7 years ago
🧪 #IDsky
www.science.org/content/arti...
🧪 #IDsky
www.science.org/content/arti...
Reposted by Audrey Leprince
Sharing new tools made by Artyom Egorov in my group!
1) loVis4u sensitively compares & visualises #phage or #plasmid seqs with beautiful vector graphics www.biorxiv.org/content/10.1...
2) iLund4u finds diversity hotspots/islands encoding eg virulence/ defence systems www.biorxiv.org/content/10.1...
1) loVis4u sensitively compares & visualises #phage or #plasmid seqs with beautiful vector graphics www.biorxiv.org/content/10.1...
2) iLund4u finds diversity hotspots/islands encoding eg virulence/ defence systems www.biorxiv.org/content/10.1...
October 24, 2024 at 11:12 AM
Sharing new tools made by Artyom Egorov in my group!
1) loVis4u sensitively compares & visualises #phage or #plasmid seqs with beautiful vector graphics www.biorxiv.org/content/10.1...
2) iLund4u finds diversity hotspots/islands encoding eg virulence/ defence systems www.biorxiv.org/content/10.1...
1) loVis4u sensitively compares & visualises #phage or #plasmid seqs with beautiful vector graphics www.biorxiv.org/content/10.1...
2) iLund4u finds diversity hotspots/islands encoding eg virulence/ defence systems www.biorxiv.org/content/10.1...