Artem Khan
@artemakhan.bsky.social
Graduate Fellow in the Birsoy Lab @RockefellerUniv | BIF PhD Fellow | NIDDK F99 Fellow | Previously: Princeton '21
Also thanks to Zachary Sebo and Navdeep Chandel for writing a preview to our work as well as a complementary study from Thomas MacVicar's lab www.cell.com/molecular-ce...
An orphan no more: SLC25A45 controls mitochondrial import of methylated amino acids
Solute carrier (SLC) genes encode the largest membrane transporter superfamily, with
many orphan members of unknown function. In recent Cell Metabolism and Molecular Cell
articles, Khan et al. and Dia...
www.cell.com
November 6, 2025 at 6:52 PM
Also thanks to Zachary Sebo and Navdeep Chandel for writing a preview to our work as well as a complementary study from Thomas MacVicar's lab www.cell.com/molecular-ce...
The link to our paper: dlvr.it/TP5gK5
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and
SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as
a key mediator of mitochondrial impo...
dlvr.it
November 6, 2025 at 6:52 PM
The link to our paper: dlvr.it/TP5gK5
The cover depicts a GWAS Manhattan plot as a city skyline reflected onto a New York City-style subway metabolic map: organelles as boroughs, metabolites as stations, transporters as trains.
November 6, 2025 at 6:52 PM
The cover depicts a GWAS Manhattan plot as a city skyline reflected onto a New York City-style subway metabolic map: organelles as boroughs, metabolites as stations, transporters as trains.
Thank you so much! I really appreciate your and Kevin's help!!
October 12, 2025 at 1:07 PM
Thank you so much! I really appreciate your and Kevin's help!!
I would like to thank KivancBirsoy
for the mentorship as well as all the authors who made this work possible FrederickYen
@nicoledelgaudio.bsky.social
@gokhanunlu8.bsky.social
RanyaErdal MichaelXiao
KhandoWangdu KevinCho EricGamazon
@gjpattij.bsky.social
for the mentorship as well as all the authors who made this work possible FrederickYen
@nicoledelgaudio.bsky.social
@gokhanunlu8.bsky.social
RanyaErdal MichaelXiao
KhandoWangdu KevinCho EricGamazon
@gjpattij.bsky.social
October 11, 2025 at 4:15 PM
I would like to thank KivancBirsoy
for the mentorship as well as all the authors who made this work possible FrederickYen
@nicoledelgaudio.bsky.social
@gokhanunlu8.bsky.social
RanyaErdal MichaelXiao
KhandoWangdu KevinCho EricGamazon
@gjpattij.bsky.social
for the mentorship as well as all the authors who made this work possible FrederickYen
@nicoledelgaudio.bsky.social
@gokhanunlu8.bsky.social
RanyaErdal MichaelXiao
KhandoWangdu KevinCho EricGamazon
@gjpattij.bsky.social
I also would like highlight two recent works on SLC45A4 nature.com/articles/s41... www.embopress.org/doi/full/10.... as well as a complementary work on SLC25A45 www.cell.com/molecular-ce...
October 11, 2025 at 4:15 PM
I also would like highlight two recent works on SLC45A4 nature.com/articles/s41... www.embopress.org/doi/full/10.... as well as a complementary work on SLC25A45 www.cell.com/molecular-ce...
Biochemically, SLC25A45 is necessary for the transport of methylated basic amino acids, such as trimethyllysine, and also ADMA.
October 11, 2025 at 4:15 PM
Biochemically, SLC25A45 is necessary for the transport of methylated basic amino acids, such as trimethyllysine, and also ADMA.
We then showed that knockout of Slc25a45 in mice leads to an impaired carnitine biosynthesis which becomes limiting under fasting conditions, compromising β-oxidation and energy homeostasis.
October 11, 2025 at 4:15 PM
We then showed that knockout of Slc25a45 in mice leads to an impaired carnitine biosynthesis which becomes limiting under fasting conditions, compromising β-oxidation and energy homeostasis.
We found SLC25A45 was significantly associated with trimethyllysine, a byproduct of protein catabolism and a precursor for carnitine biosynthesis.
October 11, 2025 at 4:15 PM
We found SLC25A45 was significantly associated with trimethyllysine, a byproduct of protein catabolism and a precursor for carnitine biosynthesis.
Here, we used a machine-learning-guided approach to uncover the function of three transporters: UNC93A and SLC45A4 as mediators of plasma membrane acetyglucosamine and polyamines transport, respectively, and SLC25A45 as a mediator of mitochondrial methylated amino acid import.
October 11, 2025 at 4:15 PM
Here, we used a machine-learning-guided approach to uncover the function of three transporters: UNC93A and SLC45A4 as mediators of plasma membrane acetyglucosamine and polyamines transport, respectively, and SLC25A45 as a mediator of mitochondrial methylated amino acid import.
We previously developed GeneMAP, a metabolic gene discovery platform, to identify SLC25A48 as necessary for mitochondrial choline transporter. www.nature.com/articles/s41...
Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import - Nature Genetics
This study presents a multiomic Gene–Metabolite Association Prediction (GeneMAP) platform for discovery of metabolic gene function and identifies SLC25A48 as a mediator of mitochondrial choline import.
www.nature.com
October 11, 2025 at 4:15 PM
We previously developed GeneMAP, a metabolic gene discovery platform, to identify SLC25A48 as necessary for mitochondrial choline transporter. www.nature.com/articles/s41...
Solute carriers are critical gatekeepers of metabolism; however, we don’t know the function of many of them as we emphasized in our recent perspective.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Solute carriers: The gatekeepers of metabolism
Khan et al. outline key challenges in studying solute carrier (SLC) proteins, critical
gatekeepers of metabolism, and propose directions for understanding their functions
in physiology and disease.
www.cell.com
October 11, 2025 at 4:15 PM
Solute carriers are critical gatekeepers of metabolism; however, we don’t know the function of many of them as we emphasized in our recent perspective.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...