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We found mechanistically, all of this is happening because CD44 curtails the diffusion of receptors at the back of the bleb. This was not due to advection of the receptors because of the fast actin retrograde flow.

Without CD44, chaos erupts! EGFR (which tells the cell where to go) roams too freely, scrambling the signals. The cell loses its sense of direction—imagine trying to drive with a GPS that keeps recalculating... You’d be lost! 📍🚗💨

Enter the guiding duo: CD44 & Ezrin—the unsung heroes who help maintain order. They grab onto the cytoskeleton and membrane, locking down key receptors (like EGFR) so they don’t just float around aimlessly. Think of them as traffic cops directing migration! 🚦🚶

But wait: Rho and Rac, the ultimate cellular GPS were completely reversed of what is in lamellipodia migration! RhoA dominates the front and Rac was driving the back.
#cellmigration

Meet our hero: a bold, adventurous cancer cell trapped in a tight, unforgiving environment. It needs to move—fast. But in these tight quarters, classic migration won’t cut it. So, it ditches the usual "crawling" and switches to something more radical: leader bleb-based migration! 💨 #CancerBiology

Without CD44, chaos erupts! EGFR (which tells the cell where to go) roams too freely, scrambling the signals. The cell loses its sense of direction—imagine trying to drive with a GPS that keeps recalculating... You’d be lost! 📍🚗💨

Enter the guiding duo: CD44 & Ezrin—the unsung heroes who help maintain order. They grab onto the cytoskeleton and membrane, locking down key receptors (like EGFR) so they don’t just float around aimlessly. Think of them as traffic cops directing migration! 🚦🚶

But wait: Rho and Rac, the ultimate cellular GPS were completely reversed of what is in lamellipodia migration! RhoA dominates the front and Rac was driving the back.

Meet our hero: a bold, adventurous cancer cell trapped in a tight, unforgiving environment. It needs to move—fast. But in these tight quarters, classic migration won’t cut it. So, it ditches the usual "crawling" and switches to something more radical: leader bleb-based migration! 💨 #CancerBiology