Andrew Wood
@andrewwood.bsky.social
Research Group Leader at the University of Edinburgh. Using genome editing and targeted protein degradation to study mechanisms underlying human disease and therapy.
Nice write up on the @mrcmousenetwork.bsky.social
website, highlighting the awesome work of first author Gillian Taylor, is available here: nmgn.mrc.ukri.org/news/underst...
website, highlighting the awesome work of first author Gillian Taylor, is available here: nmgn.mrc.ukri.org/news/underst...
Understanding the Protein Tagging Problem: A New Study from the NMGN Degron Tagging Cluster | National Mouse Genetics Network
Celebrating Research Specialists: Driving Innovation in Mouse Genetics Research specialists are often the unsung heroes in biomedical research groups, providing continuity in long-term research progra...
nmgn.mrc.ukri.org
August 26, 2025 at 12:21 PM
Nice write up on the @mrcmousenetwork.bsky.social
website, highlighting the awesome work of first author Gillian Taylor, is available here: nmgn.mrc.ukri.org/news/underst...
website, highlighting the awesome work of first author Gillian Taylor, is available here: nmgn.mrc.ukri.org/news/underst...
Has anyone else observed significant leaky (i.e. Tir1-dependent) degradation using the AID2 system? Genuinely curious to hear whether the hive mind views this as a problem.
July 21, 2025 at 11:35 AM
Has anyone else observed significant leaky (i.e. Tir1-dependent) degradation using the AID2 system? Genuinely curious to hear whether the hive mind views this as a problem.
Disclosure: I didn’t review the paper and don’t know who did, but we covered the preprint in a lab journal club last year and flagged several of the same points.
July 21, 2025 at 11:34 AM
Disclosure: I didn’t review the paper and don’t know who did, but we covered the preprint in a lab journal club last year and flagged several of the same points.
We really appreciated your contribution to this work, and for developing DEGRONOPEDIA which we use often 🙏
July 10, 2025 at 12:40 PM
We really appreciated your contribution to this work, and for developing DEGRONOPEDIA which we use often 🙏
Banger! Thanks @cellysally.bsky.social
June 20, 2025 at 10:02 AM
Banger! Thanks @cellysally.bsky.social
We characterise two underlying mechanisms with opposing effects on protein stability and explain their tissue-specificity, providing a rational basis for improved experimental design. Congrats to 1st author Gillian Taylor and all who contributed. Feedback welcome!
June 19, 2025 at 8:59 PM
We characterise two underlying mechanisms with opposing effects on protein stability and explain their tissue-specificity, providing a rational basis for improved experimental design. Congrats to 1st author Gillian Taylor and all who contributed. Feedback welcome!
By surveying a series of CRISPR-engineered mice, we found that tags often change protein expression in some tissues but have little effect, or even opposite effects, in others. Why?
June 19, 2025 at 8:58 PM
By surveying a series of CRISPR-engineered mice, we found that tags often change protein expression in some tissues but have little effect, or even opposite effects, in others. Why?
Genetic tagging is a cornerstone of modern molecular biology, but it’s no secret that tag fusion often causes unwanted changes in protein expression and function. Understanding how this happens could help us to design more refined and effective models for preclinical research.
June 19, 2025 at 8:57 PM
Genetic tagging is a cornerstone of modern molecular biology, but it’s no secret that tag fusion often causes unwanted changes in protein expression and function. Understanding how this happens could help us to design more refined and effective models for preclinical research.