Andrew Wood
@andrewwood.bsky.social
Research Group Leader at the University of Edinburgh. Using genome editing and targeted protein degradation to study mechanisms underlying human disease and therapy.
Reposted by Andrew Wood
Today's a good day to remember Rosalind Franklin, British chemist and X-ray crystallographer whose untimely death meant three men shared a Nobel prize for discovering the structure of DNA for which she'd done most of the work.
November 7, 2025 at 8:02 PM
Today's a good day to remember Rosalind Franklin, British chemist and X-ray crystallographer whose untimely death meant three men shared a Nobel prize for discovering the structure of DNA for which she'd done most of the work.
With storm Amy approaching, it’s an ideal time to get your SLiPERs on!
Hot off the press!
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4
www.nature.com/articles/s41...
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4
www.nature.com/articles/s41...
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4 - Nature Communications
Here they perform a systematic dissection of OCT4 and reveal how intrinsically disordered regions can be used to serve specific functions during reprogramming and embryonic development. This can be exploited to engineer more efficient and specific reprogramming factors.
www.nature.com
October 3, 2025 at 3:38 PM
With storm Amy approaching, it’s an ideal time to get your SLiPERs on!
Reposted by Andrew Wood
On 14th November, we are once again holding our Network Science Day in York, which is an exciting opportunity for Network members and non-members to engage and develop new collaborations!
The meeting is free to attend. Find out more and register by emailing us at [email protected].
The meeting is free to attend. Find out more and register by emailing us at [email protected].
September 16, 2025 at 12:15 PM
On 14th November, we are once again holding our Network Science Day in York, which is an exciting opportunity for Network members and non-members to engage and develop new collaborations!
The meeting is free to attend. Find out more and register by emailing us at [email protected].
The meeting is free to attend. Find out more and register by emailing us at [email protected].
Reposted by Andrew Wood
Look at this crazy thing!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
www.nature.com
September 3, 2025 at 7:05 PM
Look at this crazy thing!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. journals.plos.org/plosgenetics.... Thanks again to all coauthors, reviewers and editors for a smooth publication process. Brief summary below.
August 26, 2025 at 12:20 PM
Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. journals.plos.org/plosgenetics.... Thanks again to all coauthors, reviewers and editors for a smooth publication process. Brief summary below.
New manuscript describing a modified auxin-inducible degron system ‘AID2.1’ just out in @NatComms. www.nature.com/articles/s41.... It's worth checking out the comments of Reviewer 1 in the peer review file for this one before jumping aboard...
Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology - Nature Communications
Traditional genetic perturbation tools such as siRNA and CRISPR knockout operate on timescales that render them unsuitable for exploring dynamic processes or studying essential genes, where chronic de...
www.nature.com
July 21, 2025 at 11:33 AM
New manuscript describing a modified auxin-inducible degron system ‘AID2.1’ just out in @NatComms. www.nature.com/articles/s41.... It's worth checking out the comments of Reviewer 1 in the peer review file for this one before jumping aboard...
Reposted by Andrew Wood
Oliver Smithies was born 100 years ago today. Best known for gene targeting in mice, for which he shared the 2007 Nobel, he also developed starch gel electrophoresis in the 1950s. I met him once and remember him being very gracious and thoughtful.
#genetics #OTD
www.nobelprize.org/prizes/medic...
#genetics #OTD
www.nobelprize.org/prizes/medic...
Oliver Smithies – Facts - NobelPrize.orgOpen the search menuClose the search menuOpen the search menuClose the search menuSubmit a search termBack To Top
www.nobelprize.org
June 23, 2025 at 4:11 PM
Oliver Smithies was born 100 years ago today. Best known for gene targeting in mice, for which he shared the 2007 Nobel, he also developed starch gel electrophoresis in the 1950s. I met him once and remember him being very gracious and thoughtful.
#genetics #OTD
www.nobelprize.org/prizes/medic...
#genetics #OTD
www.nobelprize.org/prizes/medic...
Pleased to share our latest work and the first manuscript from the Degron Tagging Cluster in the MRC National Mouse Genetics Network. If you work with protein tags, particularly in tissue biology models, this should be of interest:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 19, 2025 at 8:56 PM
Pleased to share our latest work and the first manuscript from the Degron Tagging Cluster in the MRC National Mouse Genetics Network. If you work with protein tags, particularly in tissue biology models, this should be of interest:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Andrew Wood
New paper out in Genome Biology! 🎉
We lay out best-practice guidelines for releasing variant effect predictors, developed through the Atlas of Variant Effects Alliance @varianteffect.bsky.social
Open, interpretable, and clinically useful VEPs are the goal.
📄 doi.org/10.1186/s130...
We lay out best-practice guidelines for releasing variant effect predictors, developed through the Atlas of Variant Effects Alliance @varianteffect.bsky.social
Open, interpretable, and clinically useful VEPs are the goal.
📄 doi.org/10.1186/s130...
Guidelines for releasing a variant effect predictor - Genome Biology
Computational methods for assessing the likely impacts of mutations, known as variant effect predictors (VEPs), are widely used in the assessment and interpretation of human genetic variation, as well...
doi.org
April 15, 2025 at 12:24 PM
New paper out in Genome Biology! 🎉
We lay out best-practice guidelines for releasing variant effect predictors, developed through the Atlas of Variant Effects Alliance @varianteffect.bsky.social
Open, interpretable, and clinically useful VEPs are the goal.
📄 doi.org/10.1186/s130...
We lay out best-practice guidelines for releasing variant effect predictors, developed through the Atlas of Variant Effects Alliance @varianteffect.bsky.social
Open, interpretable, and clinically useful VEPs are the goal.
📄 doi.org/10.1186/s130...
Reposted by Andrew Wood
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
A Bifunctional Degrader Reads Out in Phase 3
www.science.org
March 12, 2025 at 6:53 PM
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
Reposted by Andrew Wood
Reposted by Andrew Wood
ICYMI: Commentary on "mechanism" in dev bio
Ozpolat et al argue for diverse approaches to mechanism - from molecular to systems level
journals.biologists.com/dev/article/...
Ozpolat et al argue for diverse approaches to mechanism - from molecular to systems level
journals.biologists.com/dev/article/...
A case for broadening our view of mechanism in developmental biology
ABSTRACT. Developmental biologists can perform studies that describe a phenomenon (descriptive work) and/or explain how the phenomenon works (mechanistic work). There is a prevalent perception that mo...
journals.biologists.com
February 5, 2025 at 10:56 AM
ICYMI: Commentary on "mechanism" in dev bio
Ozpolat et al argue for diverse approaches to mechanism - from molecular to systems level
journals.biologists.com/dev/article/...
Ozpolat et al argue for diverse approaches to mechanism - from molecular to systems level
journals.biologists.com/dev/article/...
Reposted by Andrew Wood
Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...
A temperature-inducible protein module for control of mammalian cell fate - Nature Methods
The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...
www.nature.com
January 23, 2025 at 6:34 PM
Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...
Reposted by Andrew Wood
🧪 Ready, set, degrade!
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
December 27, 2024 at 5:04 PM
🧪 Ready, set, degrade!
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
Reposted by Andrew Wood
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature
Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...
www.nature.com
December 18, 2024 at 4:54 PM
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Reposted by Andrew Wood
Americans are now one-third less likely to die from cancer at the same ages as Americans in 1990
December 9, 2024 at 10:02 AM
Americans are now one-third less likely to die from cancer at the same ages as Americans in 1990
Reposted by Andrew Wood
Essential reading for all that serve as reviewers. Please help your authors as if they were in your lab. Make your reviews constructive.
Overly onerous reviews amount to blocking each others’ work. It slows progress and demoralizes junior investigators.
Let’s elevate, not crush, #DevBio
Overly onerous reviews amount to blocking each others’ work. It slows progress and demoralizes junior investigators.
Let’s elevate, not crush, #DevBio
New @dev-journal.bsky.social editorial
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
We know we have high standards - but we're committed to making publishing with us constructive
From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science
journals.biologists.com/dev/article/...
Constructive Critics: Development's approach to peer review
We're all familiar with complaints about peer review. Some think it's biased – editors (especially from ‘those’ journals) seem to have too much power to decide what gets published. It can be opaque – ...
journals.biologists.com
December 2, 2024 at 12:49 PM
Essential reading for all that serve as reviewers. Please help your authors as if they were in your lab. Make your reviews constructive.
Overly onerous reviews amount to blocking each others’ work. It slows progress and demoralizes junior investigators.
Let’s elevate, not crush, #DevBio
Overly onerous reviews amount to blocking each others’ work. It slows progress and demoralizes junior investigators.
Let’s elevate, not crush, #DevBio
Reposted by Andrew Wood
New spinout Trogenix unveils its novel treatment platform that targets aggressive cancers, including brain cancer. IRR's Professor Steven Pollard is co-founder and Chief Scientific Officer #Cancer #RegenerativeMedicine #CRM regeneration-repair.ed.ac.uk/news/irr-new...
November 19, 2024 at 4:51 PM
New spinout Trogenix unveils its novel treatment platform that targets aggressive cancers, including brain cancer. IRR's Professor Steven Pollard is co-founder and Chief Scientific Officer #Cancer #RegenerativeMedicine #CRM regeneration-repair.ed.ac.uk/news/irr-new...
Reposted by Andrew Wood
Seems that @biorxivpreprint.bsky.social ought to consider adding links to @bsky.app posts given the mass transfer of scientists from Twitter to @bsky.app that is taking place.
November 18, 2024 at 1:30 AM
Seems that @biorxivpreprint.bsky.social ought to consider adding links to @bsky.app posts given the mass transfer of scientists from Twitter to @bsky.app that is taking place.