Andrew Stern
@andrewmstern.bsky.social
Neurologist and Alzheimer disease scientist at Brigham and Women’s Hospital. My lab studies beta-amyloid aggregates as they occur in human brain. Also TDP-43 biomarkers. Associate PD for research at MGB neurology residency program. sternlab.bwh.harvard.edu
If not LLPS, what term would you use to describe these quick off-rate polyvalent structures that show rapid FRAP recovery, droplet-mixing, etc? QuORPS?
November 16, 2025 at 11:44 PM
If not LLPS, what term would you use to describe these quick off-rate polyvalent structures that show rapid FRAP recovery, droplet-mixing, etc? QuORPS?
Well I see the appeal of using “liquid” as a term to describe a collection of polyvalent interactors, sliding along one another through rapid associations and dissociations. What would be a better term for this, distinct from aggregates with irreversible monovalent (oligovalent?) interactions?
November 16, 2025 at 7:33 PM
Well I see the appeal of using “liquid” as a term to describe a collection of polyvalent interactors, sliding along one another through rapid associations and dissociations. What would be a better term for this, distinct from aggregates with irreversible monovalent (oligovalent?) interactions?
Do you think it better to describe condensates as concentrations of disordered macromolecules with specific but polyvalent interactions and quick off-rates?
November 16, 2025 at 6:41 PM
Do you think it better to describe condensates as concentrations of disordered macromolecules with specific but polyvalent interactions and quick off-rates?
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
October 24, 2025 at 8:58 PM
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
Thanks guys. To be clear, I still favor that antibody directly binding to CAA could be a cause of ARIA. We just found that the difference in ARIA-E between lec and adu can’t be fully explained by differences in CAA preference.
May 22, 2025 at 12:51 PM
Thanks guys. To be clear, I still favor that antibody directly binding to CAA could be a cause of ARIA. We just found that the difference in ARIA-E between lec and adu can’t be fully explained by differences in CAA preference.
Reposted by Andrew Stern
Reposted by Andrew Stern
Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"
March 28, 2025 at 10:13 PM
Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"
Reposted by Andrew Stern
@gizemterzioglu.bsky.social will be presenting at the Microglia Symposium on the afternoon of April 4th! Her talk is titled "INPP5D/SHIP1 REGULATES MICROGLIA FUNCTION AND INFLAMMATORY RESPONSE IN ALZHEIMER'S DISEASE"
March 28, 2025 at 10:27 PM
@gizemterzioglu.bsky.social will be presenting at the Microglia Symposium on the afternoon of April 4th! Her talk is titled "INPP5D/SHIP1 REGULATES MICROGLIA FUNCTION AND INFLAMMATORY RESPONSE IN ALZHEIMER'S DISEASE"
Yes SEC followed by several techniques like ELISA, Western blot, EM, etc.
March 15, 2025 at 12:46 AM
Yes SEC followed by several techniques like ELISA, Western blot, EM, etc.