Alyssa Johnson
@alyssajohnson.bsky.social
Associate Professor at LSU using worms and flies to study lysosomes, aging, and age-related diseases. Lab website: https://faculty.lsu.edu/johnsona/index.php
Excellent work by first author graduate student Cristian Ricaurte-Perez who is currently supported by an American Heart Association predoctoral fellowship and will be applying for postdocs soon! @cristianric.bsky.social @lsuscience.bsky.social
November 11, 2025 at 4:14 PM
Excellent work by first author graduate student Cristian Ricaurte-Perez who is currently supported by an American Heart Association predoctoral fellowship and will be applying for postdocs soon! @cristianric.bsky.social @lsuscience.bsky.social
Transcriptomic analyses revealed that DAF-16 and HLH-30 cooperate to induce expression of lipid metabolism genes, including vps-34 and bec-1, that support lysosome membrane remodeling.
November 11, 2025 at 4:14 PM
Transcriptomic analyses revealed that DAF-16 and HLH-30 cooperate to induce expression of lipid metabolism genes, including vps-34 and bec-1, that support lysosome membrane remodeling.
Remarkably, experimental stimulation of lysosome tubules by over-expression of a small lysosomal gene (SVIP) promotes nuclear localization of HLH-30 in a cell autonomous and cell non-autonomous fashion, which we hypothesize contributes to systemic benefits that support healthy aging.
November 11, 2025 at 4:14 PM
Remarkably, experimental stimulation of lysosome tubules by over-expression of a small lysosomal gene (SVIP) promotes nuclear localization of HLH-30 in a cell autonomous and cell non-autonomous fashion, which we hypothesize contributes to systemic benefits that support healthy aging.
Graduate student Cristian Ricaurte-Perez, followed up on this work to uncover new regulators of lysosome tubulation. His initial work led to the discovery that DAF-16 and HLH-30, two transcription factors linked to aging regulation, are critical for efficient lysosome tubulation.
November 11, 2025 at 4:14 PM
Graduate student Cristian Ricaurte-Perez, followed up on this work to uncover new regulators of lysosome tubulation. His initial work led to the discovery that DAF-16 and HLH-30, two transcription factors linked to aging regulation, are critical for efficient lysosome tubulation.
In previous work published in @nataging.nature.com, we showed that lysosomes transform into tubular networks upon food limitation; this morphological transformation of lysosomes promotes faster autophagic cargo turnover and is required for the beneficial effects of dietary restriction.
Tubular lysosome induction couples animal starvation to healthy aging - Nature Aging
The authors report that a change to lysosome morphology, from vesicular to tubular form, supports lifespan extension upon dietary restriction and promotes heightened autophagy and healthy aging when s...
www.nature.com
November 11, 2025 at 4:14 PM
In previous work published in @nataging.nature.com, we showed that lysosomes transform into tubular networks upon food limitation; this morphological transformation of lysosomes promotes faster autophagic cargo turnover and is required for the beneficial effects of dietary restriction.
My student’s R36 (which got a great score) doesn’t have a summary statement even though it was reviewed more than 30 days ago. Assuming her SRO and PO are also not on that list but can’t search it anymore. Hasn’t been reassigned either. She has no one to contact, so it’s just in limbo.
March 15, 2025 at 12:46 PM
My student’s R36 (which got a great score) doesn’t have a summary statement even though it was reviewed more than 30 days ago. Assuming her SRO and PO are also not on that list but can’t search it anymore. Hasn’t been reassigned either. She has no one to contact, so it’s just in limbo.
My PO for my MIRA is also not listed even though she is still listed on my eraCommons.
March 13, 2025 at 1:25 AM
My PO for my MIRA is also not listed even though she is still listed on my eraCommons.
Is there any information on whether no-cost extensions will even be considered? This could be critical for many labs to keep operations going while we wait for decisions on new awards.
March 2, 2025 at 4:10 PM
Is there any information on whether no-cost extensions will even be considered? This could be critical for many labs to keep operations going while we wait for decisions on new awards.
Have 2 applications assigned to CMAD 👎🏼. Hope they get to re-schedulling these soon. Thanks for your updates!
February 27, 2025 at 5:52 PM
Have 2 applications assigned to CMAD 👎🏼. Hope they get to re-schedulling these soon. Thanks for your updates!
I completely agree. I would rather my students struggle and make mistakes. It’s part of the learning process. I worry that creative thought will decline with so much generative AI.
February 25, 2025 at 12:11 AM
I completely agree. I would rather my students struggle and make mistakes. It’s part of the learning process. I worry that creative thought will decline with so much generative AI.
Thanks for the play by play!
February 21, 2025 at 5:45 PM
Thanks for the play by play!
I think this is what you were looking for.. even a link to a google sheet with raw data for all states.
What The NIH Cut To Indirect Cost Payments Could Cost Red States
The Trump administration’s decision to cap how much NIH will pay for indirect costs on university research grants would cost 10 red states more than $1 billion.
www.forbes.com
February 10, 2025 at 7:10 PM
I think this is what you were looking for.. even a link to a google sheet with raw data for all states.
Our negotiated rate at LSU is 50% (non-medical school in a red state). I think that’s probably standard in most red states too, so 15% is a drastic cut across the board.
February 8, 2025 at 2:03 PM
Our negotiated rate at LSU is 50% (non-medical school in a red state). I think that’s probably standard in most red states too, so 15% is a drastic cut across the board.