Yes. This is a game changer. Beyond being able to replace AVS, it allows one to “see” the underlying pathological contributors to a large proportion of “idiopathic” hypertension. This is another piece of evidence that should make clinicians rethink the pathogenesis and treatment of hypertension

Seriously dumb policy.

One final is definitely not final

I think Aliza Thompson is an unsung hero in this story for spearheading the albuminuria acceptance at FDA

journals.lww.com/cjasn/pages/...

#NephJC

💯 deserves a ton of credit for moving things forward

will get my excellent genetic counselor to work on it!

Been awhile but found it! Col4a5 c.231 +2T>C

Ah makes sense…working on a one-pager for patients in this setting. Strangely, colleague had a male in 30s with col4a5 asymptomatic without hematuria and proteinuria, normal GFR, detected on reproductive screening genetic test done prior to marriage

Looked pretty mid

Are you seeing asymptomatic prospective parents that have COL4A5?