Alex Stark
@alex-stark.bsky.social
Scientist at IMP in Vienna. Excited about gene expression regulation and its encoding in our genomes - enhancers, transcription factors, co-factors, silencers, AI.
Reposted by Alex Stark
Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export?
Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)
Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)
November 21, 2025 at 5:02 AM
Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export?
Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)
Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)
Reposted by Alex Stark
Lastly, I’m excited to join @imbmainz.bsky.social in 2026 to start my own lab. We'll explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. tinyurl.com/y4x29ctt
Thanks for reading! 20/20
Thanks for reading! 20/20
Research
IMB Mainz
tinyurl.com
November 19, 2025 at 11:22 PM
Lastly, I’m excited to join @imbmainz.bsky.social in 2026 to start my own lab. We'll explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. tinyurl.com/y4x29ctt
Thanks for reading! 20/20
Thanks for reading! 20/20
Reposted by Alex Stark
My first @umasschan.bsky.social/@impvienna.bsky.social affiliated paper is up!
tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs.
Check it out!
academic.oup.com/bioinformati...
tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs.
Check it out!
academic.oup.com/bioinformati...
November 20, 2025 at 2:02 PM
My first @umasschan.bsky.social/@impvienna.bsky.social affiliated paper is up!
tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs.
Check it out!
academic.oup.com/bioinformati...
tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs.
Check it out!
academic.oup.com/bioinformati...
Reposted by Alex Stark
🎉 Congrats to @aelewaut.bsky.social for winning the 2024 #DenisePBarlowAward! 🎖️
She carried out her PhD thesis in @obenaufa.bsky.social's lab (@impvienna.bsky.social), work published in @nature.com.
📄 Paper: rdcu.be/eQv1f
➡️ About the award: bit.ly/3iFbafP
She carried out her PhD thesis in @obenaufa.bsky.social's lab (@impvienna.bsky.social), work published in @nature.com.
📄 Paper: rdcu.be/eQv1f
➡️ About the award: bit.ly/3iFbafP
November 18, 2025 at 1:18 PM
🎉 Congrats to @aelewaut.bsky.social for winning the 2024 #DenisePBarlowAward! 🎖️
She carried out her PhD thesis in @obenaufa.bsky.social's lab (@impvienna.bsky.social), work published in @nature.com.
📄 Paper: rdcu.be/eQv1f
➡️ About the award: bit.ly/3iFbafP
She carried out her PhD thesis in @obenaufa.bsky.social's lab (@impvienna.bsky.social), work published in @nature.com.
📄 Paper: rdcu.be/eQv1f
➡️ About the award: bit.ly/3iFbafP
Reposted by Alex Stark
Looks like the previous link is not working... here's a working link! www.biorxiv.org/content/10.1...
November 18, 2025 at 8:49 PM
Looks like the previous link is not working... here's a working link! www.biorxiv.org/content/10.1...
Reposted by Alex Stark
Link to preprint: www.biorxiv.org/content/2025...
www.biorxiv.org
November 18, 2025 at 3:57 PM
Link to preprint: www.biorxiv.org/content/2025...
Reposted by Alex Stark
This has been an amazing collaborative project that keeps on giving. We now have a new 3x larger eORFeome and we will dive deep into pathogen and host biology. If you are interested in scalable approaches to study effectors and their interactions with the host, get in touch! 8/8
November 18, 2025 at 3:57 PM
This has been an amazing collaborative project that keeps on giving. We now have a new 3x larger eORFeome and we will dive deep into pathogen and host biology. If you are interested in scalable approaches to study effectors and their interactions with the host, get in touch! 8/8
Reposted by Alex Stark
Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
www.biorxiv.org
November 18, 2025 at 3:57 PM
Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 2:51 PM
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Reposted by Alex Stark
Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways https://www.biorxiv.org/content/10.1101/2025.11.17.687821v1
November 18, 2025 at 3:03 AM
Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways https://www.biorxiv.org/content/10.1101/2025.11.17.687821v1
Reposted by Alex Stark
Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!
September 11, 2025 at 6:09 AM
Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!
Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!
September 11, 2025 at 6:09 AM
Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!