Harry H Behjat
@aitchbi.bsky.social
imaging neuroscience • data science on graphs • brain structure-function-pathology interplay • spatial methods • MRI PET • Alzheimer’s disease
🌐 https://linktr.ee/aitchbi
🌐 https://linktr.ee/aitchbi
[🧵12] this work rests on the pivotal guidance of my advisory team @jwvogel.bsky.social Oskar Hansson @rikossenkoppele.bsky.social + decisive inputs from Ruben Smith & @dimitrivdv.bsky.social + plus the contributions of other brilliant minds at the @biofinder.bsky.social & demonlab.org labs 🙌
October 7, 2025 at 8:59 AM
[🧵12] this work rests on the pivotal guidance of my advisory team @jwvogel.bsky.social Oskar Hansson @rikossenkoppele.bsky.social + decisive inputs from Ruben Smith & @dimitrivdv.bsky.social + plus the contributions of other brilliant minds at the @biofinder.bsky.social & demonlab.org labs 🙌
[🧵11] altogether, our findings provide strong evidence that individual functional brain architecture shapes tau propagation in humans, supporting the network-spread hypothesis by showing that variability in connectivity translates into heterogeneity in tau distribution 🧠
October 7, 2025 at 8:59 AM
[🧵11] altogether, our findings provide strong evidence that individual functional brain architecture shapes tau propagation in humans, supporting the network-spread hypothesis by showing that variability in connectivity translates into heterogeneity in tau distribution 🧠
[🧵10] all the answers given above are "yes", however, with their own ifs and buts; pls make sure to check the details in the manuscript 🔎 www.biorxiv.org/content/10.1...
Patient-specific functional brain architecture explains cortical patterns of tau PET in Alzheimer's disease
The spatial distribution of tau pathology, the core driver of neurodegeneration in Alzheimer's disease (AD), varies markedly across individuals. While tau is thought to spread along brain networks, th...
www.biorxiv.org
October 7, 2025 at 8:59 AM
[🧵10] all the answers given above are "yes", however, with their own ifs and buts; pls make sure to check the details in the manuscript 🔎 www.biorxiv.org/content/10.1...
[🧵9] fourth, we asked, does FC also have prognostic value, that is, does individualised FC explain individual follow-up tau-PET patterns? it does.
October 7, 2025 at 8:59 AM
[🧵9] fourth, we asked, does FC also have prognostic value, that is, does individualised FC explain individual follow-up tau-PET patterns? it does.
[🧵8] third, we asked, is the superior explanatory power of FC over canonical PET patterns specific to tau and
absent for e.g. B-amyloid pathology? it is.
absent for e.g. B-amyloid pathology? it is.
October 7, 2025 at 8:59 AM
[🧵8] third, we asked, is the superior explanatory power of FC over canonical PET patterns specific to tau and
absent for e.g. B-amyloid pathology? it is.
absent for e.g. B-amyloid pathology? it is.
[🧵7] second, as a largely overlooked dimension, we asked, does FC actually perform better in explaining individual tau-PET patterns than just using canonical patterns of tau-PET? it does.
October 7, 2025 at 8:59 AM
[🧵7] second, as a largely overlooked dimension, we asked, does FC actually perform better in explaining individual tau-PET patterns than just using canonical patterns of tau-PET? it does.
[🧵6] first, we asked, does patient-specific FC help better to better explain the variance in individual tau-PET patterns than group-level FC does? it does.
October 7, 2025 at 8:59 AM
[🧵6] first, we asked, does patient-specific FC help better to better explain the variance in individual tau-PET patterns than group-level FC does? it does.
[🧵5] in a large sample of deeply phenotyped patients across the AD continuum from @biofinder.bsky.social, we rigorously validated, at the individual level, the association between patterns of tau-PET and functional connectivity, on four fronts.
October 7, 2025 at 8:59 AM
[🧵5] in a large sample of deeply phenotyped patients across the AD continuum from @biofinder.bsky.social, we rigorously validated, at the individual level, the association between patterns of tau-PET and functional connectivity, on four fronts.
[🧵4] this is particularly important, since patterns of tau as captured by PET scans vary markedly across individuals and the role of inter-individual variability in shaping these patterns remains underexplored. e.g. see:
rdcu.be/eJKD5
rdcu.be/eJKD5
Four distinct trajectories of tau deposition identified in Alzheimer’s disease
Nature Medicine - Systematic characterization of longitudinal tau variability in human Alzheimer’s disease using an unbiased subtyping algorithm reveals four trajectories of tau deposition...
rdcu.be
October 7, 2025 at 8:59 AM
[🧵4] this is particularly important, since patterns of tau as captured by PET scans vary markedly across individuals and the role of inter-individual variability in shaping these patterns remains underexplored. e.g. see:
rdcu.be/eJKD5
rdcu.be/eJKD5
[🧵3] most evidence from human studies on this hypothesis, however, is based on group-level models of brain networks.
to truly validate the hypothesis, we need to go beyond group means, and work at the individual level.
to truly validate the hypothesis, we need to go beyond group means, and work at the individual level.
October 7, 2025 at 8:59 AM
[🧵3] most evidence from human studies on this hypothesis, however, is based on group-level models of brain networks.
to truly validate the hypothesis, we need to go beyond group means, and work at the individual level.
to truly validate the hypothesis, we need to go beyond group means, and work at the individual level.