Ashley Frakes
@afrakes.bsky.social
Stadtman tenure-track investigator @NIH. Previously, Post-doc @UCBerkeley in @DillinLab. PhD @OSU @Nationwidekids in Kaspar lab. Opinions are my own &can change
https://www.niddk.nih.gov/about-niddk/staff-directory/biography/frakes-ashley
https://www.niddk.nih.gov/about-niddk/staff-directory/biography/frakes-ashley
Thank you for posting!
October 2, 2025 at 3:42 PM
Thank you for posting!
Congrats David!! Excited to see what’s to come!
April 1, 2025 at 10:23 AM
Congrats David!! Excited to see what’s to come!
Here, through whole animal scRNA-seq, neuropeptidomics, and genetic screens awesome post-doc, Carrie Sheeler, answers those questions! Thank you collaborators @jennifergarrison.bsky.social 's lab and Kenyon lab!
March 21, 2025 at 3:20 PM
Here, through whole animal scRNA-seq, neuropeptidomics, and genetic screens awesome post-doc, Carrie Sheeler, answers those questions! Thank you collaborators @jennifergarrison.bsky.social 's lab and Kenyon lab!
I previously found that subtype of four astrocyte-like regulate organismal ER stress resistance and longevity.
science.org/doi/10.1126/...
However, the signal and full extent of the cell non-autonomous response remained unknown.
science.org/doi/10.1126/...
However, the signal and full extent of the cell non-autonomous response remained unknown.
Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans
Organismal protein homeostasis and longevity in nematodes are coordinated by a subtype of glia.
science.org
March 21, 2025 at 3:20 PM
I previously found that subtype of four astrocyte-like regulate organismal ER stress resistance and longevity.
science.org/doi/10.1126/...
However, the signal and full extent of the cell non-autonomous response remained unknown.
science.org/doi/10.1126/...
However, the signal and full extent of the cell non-autonomous response remained unknown.
Congrats to Karmen Mah and Adam Roszczyk who figured out this initially puzzling observation! 🥳
March 18, 2025 at 5:37 PM
Congrats to Karmen Mah and Adam Roszczyk who figured out this initially puzzling observation! 🥳
· Mice with maternally inherited hGFAP-creERT2 exhibited no Cre-mediated recombination
· Recombination was robust in mice with paternally inherited hGFAP-creERT2
· Inheritance effect is NOT transgenerational
· Suppression of recombination was observed independent of colony.
· Recombination was robust in mice with paternally inherited hGFAP-creERT2
· Inheritance effect is NOT transgenerational
· Suppression of recombination was observed independent of colony.
March 18, 2025 at 5:37 PM
· Mice with maternally inherited hGFAP-creERT2 exhibited no Cre-mediated recombination
· Recombination was robust in mice with paternally inherited hGFAP-creERT2
· Inheritance effect is NOT transgenerational
· Suppression of recombination was observed independent of colony.
· Recombination was robust in mice with paternally inherited hGFAP-creERT2
· Inheritance effect is NOT transgenerational
· Suppression of recombination was observed independent of colony.
A PSA for #astrocyte aficionados working with GFAP-CreERT2 mice from @jacksonlab.bsky.social (#012849)
March 18, 2025 at 5:37 PM
A PSA for #astrocyte aficionados working with GFAP-CreERT2 mice from @jacksonlab.bsky.social (#012849)