Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
@aesposito1975.bsky.social
#Physicist and cancer #biologist studying how molecular networks encode cell decisions and how mutations hijack cells, leading to #cancer.
Centre for Genome Engineering and Maintenance
Brunel University of London
Centre for Genome Engineering and Maintenance
Brunel University of London
Pinned
EMBO Reports - FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer
open.spotify.com
The audio overview of our latest paper is now available on Spotify: open.spotify.com/episode/6ej9...
#KRAS #metabolism
#KRAS #metabolism
Reposted by Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
When is a #modelsystem relevant? Interesting reflections by Dr Christian Rudolph
rudolphlab.com/blog/on-narr...
rudolphlab.com/blog/on-narr...
Rudolph BLOG
Pages of the Rudolph laboratory at Brunel University London.
rudolphlab.com
November 28, 2025 at 2:21 PM
When is a #modelsystem relevant? Interesting reflections by Dr Christian Rudolph
rudolphlab.com/blog/on-narr...
rudolphlab.com/blog/on-narr...
The audio overview of our latest paper is now available on Spotify: open.spotify.com/episode/6ej9...
#KRAS #metabolism
#KRAS #metabolism
EMBO Reports - FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer
open.spotify.com
November 28, 2025 at 12:03 PM
The audio overview of our latest paper is now available on Spotify: open.spotify.com/episode/6ej9...
#KRAS #metabolism
#KRAS #metabolism
I use #NotebookLM quite a bit for work. Useful for converting your content (in this case, our latest paper) into different formats. Here a #mindmap of "FOXO1 links #KRAS G12D and G12V alleles to glutamine and nitrogen #metabolism in #colorectalcancer" doi.org/10.1038/s443...
November 26, 2025 at 8:02 PM
I use #NotebookLM quite a bit for work. Useful for converting your content (in this case, our latest paper) into different formats. Here a #mindmap of "FOXO1 links #KRAS G12D and G12V alleles to glutamine and nitrogen #metabolism in #colorectalcancer" doi.org/10.1038/s443...
Reposted by Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
www.embopress.org/doi/full/10....
Congratulations to Dilem Shakir, Michael Batie, Chun-Sui Kwok, Niall Kenneth and @srochaliv.bsky.social on their their lovely study describing NF-κB’s central role in the hypoxia response - just out in EMBO Reports. A pleasure to collaborate with Team Rocha!!👏 🍾 👌
Congratulations to Dilem Shakir, Michael Batie, Chun-Sui Kwok, Niall Kenneth and @srochaliv.bsky.social on their their lovely study describing NF-κB’s central role in the hypoxia response - just out in EMBO Reports. A pleasure to collaborate with Team Rocha!!👏 🍾 👌
NF-κB is a central regulator of hypoxia-induced gene expression | EMBO reports
imageimageHypoxia induces a specific NF-κB-dependent gene signature across multiple cell systems.
NF-κB is required for over 60% of gene repression occurring in response to hypoxia,
controlling oxidat...
www.embopress.org
November 26, 2025 at 6:36 PM
www.embopress.org/doi/full/10....
Congratulations to Dilem Shakir, Michael Batie, Chun-Sui Kwok, Niall Kenneth and @srochaliv.bsky.social on their their lovely study describing NF-κB’s central role in the hypoxia response - just out in EMBO Reports. A pleasure to collaborate with Team Rocha!!👏 🍾 👌
Congratulations to Dilem Shakir, Michael Batie, Chun-Sui Kwok, Niall Kenneth and @srochaliv.bsky.social on their their lovely study describing NF-κB’s central role in the hypoxia response - just out in EMBO Reports. A pleasure to collaborate with Team Rocha!!👏 🍾 👌
Are you interested in oncogenic #KRAS and #metabolism? Our latest study reveals how specific KRAS G12D and G12V alleles rewire #glutamine and #nitrogen metabolism in #colorectalcancer through a #FOXO1-dependent pathway.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports
imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer
cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling,
uncovering a vuln...
www.embopress.org
November 23, 2025 at 5:10 PM
Are you interested in oncogenic #KRAS and #metabolism? Our latest study reveals how specific KRAS G12D and G12V alleles rewire #glutamine and #nitrogen metabolism in #colorectalcancer through a #FOXO1-dependent pathway.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
www.embopress.org/doi/full/10....
Congratulations to Suzan Ber and @aesposito1975.bsky.social on their lovely study of KRAS alleles on glutamine and nitrogen metablism and signalling - just out in EMBO Reports. Such a pleasure to collaborate on this fascinating project! 👏
Congratulations to Suzan Ber and @aesposito1975.bsky.social on their lovely study of KRAS alleles on glutamine and nitrogen metablism and signalling - just out in EMBO Reports. Such a pleasure to collaborate on this fascinating project! 👏
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports
imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer
cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling,
uncovering a vuln...
www.embopress.org
November 21, 2025 at 9:20 AM
www.embopress.org/doi/full/10....
Congratulations to Suzan Ber and @aesposito1975.bsky.social on their lovely study of KRAS alleles on glutamine and nitrogen metablism and signalling - just out in EMBO Reports. Such a pleasure to collaborate on this fascinating project! 👏
Congratulations to Suzan Ber and @aesposito1975.bsky.social on their lovely study of KRAS alleles on glutamine and nitrogen metablism and signalling - just out in EMBO Reports. Such a pleasure to collaborate on this fascinating project! 👏
Reposted by Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
Another key milestone in the #HILIGHTProject development roadmap 📈
Our first multi-section 905 nm laser purpose-built for #2phFLIM is fabricated! 🔬
🧪 Next: characterisation at #III-VLab.
@csem.ch , #BrunelUniversityLondon, @aesposito1975.bsky.social, #FBK, #VivaScope
hilighthorizon.eu/blog/
Our first multi-section 905 nm laser purpose-built for #2phFLIM is fabricated! 🔬
🧪 Next: characterisation at #III-VLab.
@csem.ch , #BrunelUniversityLondon, @aesposito1975.bsky.social, #FBK, #VivaScope
hilighthorizon.eu/blog/
HILIGHT
EU HORIZON project
hilighthorizon.eu
October 27, 2025 at 3:02 PM
Another key milestone in the #HILIGHTProject development roadmap 📈
Our first multi-section 905 nm laser purpose-built for #2phFLIM is fabricated! 🔬
🧪 Next: characterisation at #III-VLab.
@csem.ch , #BrunelUniversityLondon, @aesposito1975.bsky.social, #FBK, #VivaScope
hilighthorizon.eu/blog/
Our first multi-section 905 nm laser purpose-built for #2phFLIM is fabricated! 🔬
🧪 Next: characterisation at #III-VLab.
@csem.ch , #BrunelUniversityLondon, @aesposito1975.bsky.social, #FBK, #VivaScope
hilighthorizon.eu/blog/
Happy new academic year for all our students and colleagues at Brunel.
#bruneluniversity #success @cengem.bsky.social
#bruneluniversity #success @cengem.bsky.social
September 22, 2025 at 10:39 AM
Happy new academic year for all our students and colleagues at Brunel.
#bruneluniversity #success @cengem.bsky.social
#bruneluniversity #success @cengem.bsky.social
New Microscopills episode!
We explore optogenetics: the science of using light to control living cells. From mapping brain circuits to controlling biochemical reactions, a 5-minute guide to optogenetics.
open.spotify.com/episode/4e7j...
#Microscopills #Optogenetics #SciencePodcast
We explore optogenetics: the science of using light to control living cells. From mapping brain circuits to controlling biochemical reactions, a 5-minute guide to optogenetics.
open.spotify.com/episode/4e7j...
#Microscopills #Optogenetics #SciencePodcast
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
September 8, 2025 at 10:17 AM
New Microscopills episode!
We explore optogenetics: the science of using light to control living cells. From mapping brain circuits to controlling biochemical reactions, a 5-minute guide to optogenetics.
open.spotify.com/episode/4e7j...
#Microscopills #Optogenetics #SciencePodcast
We explore optogenetics: the science of using light to control living cells. From mapping brain circuits to controlling biochemical reactions, a 5-minute guide to optogenetics.
open.spotify.com/episode/4e7j...
#Microscopills #Optogenetics #SciencePodcast
Amazing news! Looking forward to this new sensor. FBK is doing an amazing job as always!!!
Great news!
The first #HILIGHTProject detector built at FBK and now under test. A key step for delivering digital #FluorescenceLifetime at record speed. Next: integration with laser sources from @csem.ch+III-V Lab at Brunel University @aesposito1975.bsky.social+VIVASCOPE
hilighthorizon.eu/blog/
The first #HILIGHTProject detector built at FBK and now under test. A key step for delivering digital #FluorescenceLifetime at record speed. Next: integration with laser sources from @csem.ch+III-V Lab at Brunel University @aesposito1975.bsky.social+VIVASCOPE
hilighthorizon.eu/blog/
HILIGHT
EU HORIZON project
hilighthorizon.eu
August 22, 2025 at 11:12 AM
Amazing news! Looking forward to this new sensor. FBK is doing an amazing job as always!!!
#GPT5 is out. Superslow but the level of detail that gives is impressive at least as judged from initial accidental (I had not noticed it was rolled out as I was working on custom GPTs) use!
August 7, 2025 at 9:22 PM
#GPT5 is out. Superslow but the level of detail that gives is impressive at least as judged from initial accidental (I had not noticed it was rolled out as I was working on custom GPTs) use!
Great opportunity for a bioinformatician to join an amazing lab in #Amsterdam #JobOpportunity #bioinformatics #gastruloids
www.sanquin.org/working-at/v...
www.sanquin.org/working-at/v...
Computational biologist / Bioinformatician - Computational biologist / Bioinformatician
detail
www.sanquin.org
July 24, 2025 at 9:20 AM
Great opportunity for a bioinformatician to join an amazing lab in #Amsterdam #JobOpportunity #bioinformatics #gastruloids
www.sanquin.org/working-at/v...
www.sanquin.org/working-at/v...
Reposted by Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
We now have the audio summary of "#BMP antagonist #CHRDL2 enhances the #cancer #stemcell phenotype and increases #chemotherapy resistance in #colorectal cancer" by Eloise Clarkson and Annabelle Lewis published in Molecular Oncology
open.spotify.com/episode/3vv8...
open.spotify.com/episode/3vv8...
E03 - CHRDL2 in Colorectal Cancer [New paper from Lewis Lab]
CenGEM | Centre for Genome Engineering and Maintenance · Episode
open.spotify.com
July 3, 2025 at 2:47 PM
We now have the audio summary of "#BMP antagonist #CHRDL2 enhances the #cancer #stemcell phenotype and increases #chemotherapy resistance in #colorectal cancer" by Eloise Clarkson and Annabelle Lewis published in Molecular Oncology
open.spotify.com/episode/3vv8...
open.spotify.com/episode/3vv8...
Reposted by Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
🚀 Discover the future of diagnostics! The Hilight Project is revolutionising biomedical research with cutting-edge laser technology 🔬.
#HighlightProject #DigitalDiagnostics #BiomedicalResearch #LaserTechnology #FLIMImaging #Innovation #MedicalTech
See the video presentation at hilighthorizon.eu
#HighlightProject #DigitalDiagnostics #BiomedicalResearch #LaserTechnology #FLIMImaging #Innovation #MedicalTech
See the video presentation at hilighthorizon.eu
HILIGHT
EU HORIZON project
hilighthorizon.eu
July 1, 2025 at 2:27 PM
🚀 Discover the future of diagnostics! The Hilight Project is revolutionising biomedical research with cutting-edge laser technology 🔬.
#HighlightProject #DigitalDiagnostics #BiomedicalResearch #LaserTechnology #FLIMImaging #Innovation #MedicalTech
See the video presentation at hilighthorizon.eu
#HighlightProject #DigitalDiagnostics #BiomedicalResearch #LaserTechnology #FLIMImaging #Innovation #MedicalTech
See the video presentation at hilighthorizon.eu
Interested in applying for #MSCA fellowships and working at the interface between #biology and #physics?
quantitative-biology.org/do-you-need-...
quantitative-biology.org/do-you-need-...
Do you need a host for a MSCA fellowship (2025)?
Having re-established my laboratory at Brunel University of London, I am now open to supporting junior researchers interested in applying for independent funding through the EU MSCA scheme. I offer…
quantitative-biology.org
May 23, 2025 at 6:28 AM
Interested in applying for #MSCA fellowships and working at the interface between #biology and #physics?
quantitative-biology.org/do-you-need-...
quantitative-biology.org/do-you-need-...
Reposted by Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
Hard-working and smart, nothing else defines a #scientist or an #engineer. A scientist, an engineer, is someone like you. If you are considering a path in science or technology, know this: your ideas belong here because our #superpower is you!
#oursuperpowerisyou
hilighthorizon.eu/edi/
#oursuperpowerisyou
hilighthorizon.eu/edi/
May 21, 2025 at 12:42 PM
Hard-working and smart, nothing else defines a #scientist or an #engineer. A scientist, an engineer, is someone like you. If you are considering a path in science or technology, know this: your ideas belong here because our #superpower is you!
#oursuperpowerisyou
hilighthorizon.eu/edi/
#oursuperpowerisyou
hilighthorizon.eu/edi/
Reposted by Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
Another reason to like MEKI!
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease | Science Translational Medicine www.science.org/doi/10.1126/...
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease
MEK1/2 inhibitors lowered pathological αsyn in a humanized mouse model, suggesting an oral treatment strategy for Parkinson’s disease.
www.science.org
May 15, 2025 at 10:27 PM
Another reason to like MEKI!
Reposted by Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
We are releasing our EDI campaign material. Help us by using/reusing/altering our work and distributing it to schools, Universities and events. Just a small action, part of a larger commitment and ongoing conversation.
hilighthorizon.eu/edi/
#EDI #WomenInSTEM
hilighthorizon.eu/edi/
#EDI #WomenInSTEM
May 15, 2025 at 4:58 PM
We are releasing our EDI campaign material. Help us by using/reusing/altering our work and distributing it to schools, Universities and events. Just a small action, part of a larger commitment and ongoing conversation.
hilighthorizon.eu/edi/
#EDI #WomenInSTEM
hilighthorizon.eu/edi/
#EDI #WomenInSTEM
Reposted by Alessandro Esposito 👨🔬🔬🧬👨👩👧🇪🇺🏳️🌈
This is an old post, but I would like to propose it again as I am new here.
This is a topic I am very passionate about. I hope you will enjoy the read, and you will find it useful. Happy to hear your views about the topic.
The mindful scientist network.febs.org/posts/the-mi... #FEBSnet
The mindful scientist
A more mindful approach to science can help scientists to handle negative and positive emotions better.
network.febs.org
November 13, 2024 at 6:24 PM
This is an old post, but I would like to propose it again as I am new here.
This is a topic I am very passionate about. I hope you will enjoy the read, and you will find it useful. Happy to hear your views about the topic.
The mindful scientist network.febs.org/posts/the-mi... #FEBSnet
Good morning! Today we publish three new #MicroscoPills about #confocal #microscopy.
E03 - What is it and why is it useful in #biology
E04 - Confocal microscopy history and evolution
E05 - The role of the confocal #pinhole
Follow us on Spotify
open.spotify.com/show/20hJTM4...
#science
E03 - What is it and why is it useful in #biology
E04 - Confocal microscopy history and evolution
E05 - The role of the confocal #pinhole
Follow us on Spotify
open.spotify.com/show/20hJTM4...
#science
MicroscoPills: your bite-sized dose of microscopy concepts
Podcast · Dr Alessandro Esposito · Unlock the tiny world with short episodes on microscopy and its application to biology and biomedical research. Discover how these tools visualise life at the molecu...
open.spotify.com
May 11, 2025 at 7:04 AM
Good morning! Today we publish three new #MicroscoPills about #confocal #microscopy.
E03 - What is it and why is it useful in #biology
E04 - Confocal microscopy history and evolution
E05 - The role of the confocal #pinhole
Follow us on Spotify
open.spotify.com/show/20hJTM4...
#science
E03 - What is it and why is it useful in #biology
E04 - Confocal microscopy history and evolution
E05 - The role of the confocal #pinhole
Follow us on Spotify
open.spotify.com/show/20hJTM4...
#science
Hear the #women shaping #stemcell science! Discover the resilience, breakthroughs, and essential insights of female pioneers driving innovation in the field.
open.spotify.com/episode/1lY9...
This podcast explores their challenges, triumphs, and vital perspectives.
open.spotify.com/episode/1lY9...
This podcast explores their challenges, triumphs, and vital perspectives.
May 10, 2025 at 12:10 PM
Hear the #women shaping #stemcell science! Discover the resilience, breakthroughs, and essential insights of female pioneers driving innovation in the field.
open.spotify.com/episode/1lY9...
This podcast explores their challenges, triumphs, and vital perspectives.
open.spotify.com/episode/1lY9...
This podcast explores their challenges, triumphs, and vital perspectives.
New podcasts
E02 - The central 'dogma' of molecular biology
E03 - The structure of nucleic acids
on Spotify, based on material presented in BB5708 Gene Expression and Epigenetics, MSc study block back in 2023.
open.spotify.com/show/28L6aSR...
#genes #genomes #centraldogma #dna #rna
E02 - The central 'dogma' of molecular biology
E03 - The structure of nucleic acids
on Spotify, based on material presented in BB5708 Gene Expression and Epigenetics, MSc study block back in 2023.
open.spotify.com/show/28L6aSR...
#genes #genomes #centraldogma #dna #rna
Esposito's Lectures
Podcast · Dr Alessandro Esposito · Hello there... I am Dr Alessandro Esposito (Brunel University of London). Although my lectures are on our proprietary digital learning platform, I make them availab...
open.spotify.com
May 6, 2025 at 2:19 PM
New podcasts
E02 - The central 'dogma' of molecular biology
E03 - The structure of nucleic acids
on Spotify, based on material presented in BB5708 Gene Expression and Epigenetics, MSc study block back in 2023.
open.spotify.com/show/28L6aSR...
#genes #genomes #centraldogma #dna #rna
E02 - The central 'dogma' of molecular biology
E03 - The structure of nucleic acids
on Spotify, based on material presented in BB5708 Gene Expression and Epigenetics, MSc study block back in 2023.
open.spotify.com/show/28L6aSR...
#genes #genomes #centraldogma #dna #rna
An introduction to #genes and #genomes, MSc #lecture I gave a couple of years ago, now on Spotify in the form of a conversational podcast. Next up: the central 'dogma' of molecular biology.
open.spotify.com/episode/3t2e...
open.spotify.com/episode/3t2e...
BB5708 - Genes and Genomes
open.spotify.com
May 5, 2025 at 10:47 AM
An introduction to #genes and #genomes, MSc #lecture I gave a couple of years ago, now on Spotify in the form of a conversational podcast. Next up: the central 'dogma' of molecular biology.
open.spotify.com/episode/3t2e...
open.spotify.com/episode/3t2e...
My #KRAS lectures for our MSc in #BB5715 #Cancer #Biology Mechanisms and Treatment MSc Brunel University of London are also on Spotify as a conversational podcast.
open.spotify.com/show/28L6aSR...
open.spotify.com/show/28L6aSR...
Esposito's Lectures
Podcast · Dr Alessandro Esposito · Hello there... I am Dr Alessandro Esposito (Brunel University of London). Although my lectures are on our proprietary digital learning platform, I make them availab...
open.spotify.com
May 3, 2025 at 4:39 PM
My #KRAS lectures for our MSc in #BB5715 #Cancer #Biology Mechanisms and Treatment MSc Brunel University of London are also on Spotify as a conversational podcast.
open.spotify.com/show/28L6aSR...
open.spotify.com/show/28L6aSR...
Do you need another dose of #microscopy? The second episode of #MicroscoPills is available on Spotify. An introduction to #Fluorescence #Lifetime Imaging Microscopy #FLIM
open.spotify.com/episode/6u9a...
open.spotify.com/episode/6u9a...
Microscopills E02 - Fluorescence Lifetime Imaging Microscopy (FLIM) Primer: the basics
Quantitative Biology: Papers and Perspectives · Episode
open.spotify.com
May 2, 2025 at 1:41 PM
Do you need another dose of #microscopy? The second episode of #MicroscoPills is available on Spotify. An introduction to #Fluorescence #Lifetime Imaging Microscopy #FLIM
open.spotify.com/episode/6u9a...
open.spotify.com/episode/6u9a...