The Lancet Neurology
@thelancetneuro.bsky.social
The Lancet Neurology is the leading journal in clinical neurology. We publish articles and reviews that advocate change in, or illuminate, clinical practice.
🌐 https://www.thelancet.com/journals/laneur/home
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NEW ISSUE: Our January 2026 issue is now live and includes the annual Round-up of key advances in research in neurological disorders in 2025. Read more at: thelancet.com/journals/lan...
Reposted by The Lancet Neurology, The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
· 11d
Ageing is associated with cognitive decline & an increased risk of neurodegenerative diseases.
A Review explores the neuroprotective mechanisms of endurance exercise & highlights the importance of cardiorespiratory fitness in healthy brain ageing: spkl.io/63323Aia89
A Review explores the neuroprotective mechanisms of endurance exercise & highlights the importance of cardiorespiratory fitness in healthy brain ageing: spkl.io/63323Aia89
Migraine as a dynamic continuum during the life course
Traditionally, migraine is defined by the occurrence of cycling episodes of headache
and associated neurological symptoms, with a primary focus on the presence of a migraine
episode at a specific poin...
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In our January issue, the authors of an Insight paper propose that "Recognition of active, inactive, and interictal states of migraine is crucial for a more comprehensive understanding of the disease across the life course" www.thelancet.com/journals/lan...
Endovascular thrombectomy for acute stroke: evolving eligibility criteria and adjunct therapies
Endovascular thrombectomy is the standard treatment for ischaemic stroke, a leading
cause of disability worldwide. Randomised trials in the past decade have expanded
eligibility criteria to include br...
thelancet.com
In their Review, Martina Glavan and colleagues discuss how biological targets align with the pathophysiological timeline of primary and secondary injury following ischaemic stroke. thelancet.com/journals/lan...
Seizure-related biomarkers of sudden unexpected death in epilepsy (SUDEP) in drug-resistant focal epilepsy (REPO2MSE): a prospective, multicentre case–control study
Extratemporal epilepsies involving the perisylvian region or frontal lobe appear to
be associated with an increased risk of SUDEP. This finding warrants confirmation
in larger cohorts and underscores ...
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Philippe Ryvlin and colleagues report the results of a case–control study showing that extratemporal epilepsies involving the perisylvian region or frontal lobe appear to be associated with an increased risk of SUDEP www.thelancet.com/journals/lan...
Azathioprine for the treatment of early Parkinson's disease (AZA-PD): a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial
Azathioprine was well-tolerated in this population; however, the primary outcome was
not met. Exploratory analyses suggested effects of azathioprine on peripheral and
central immune biomarkers and on ...
thelancet.com
Julia Greenland and colleagues report the results of a phase 2 RCT exploring the safety and efficacy of azathioprine for the treatment of early Parkinson's disease: thelancet.com/journals/lan...
Turning policy into action for brain health
Neurological disorders are among the leading causes of disability worldwide, yet millions
of people still lack access to effective care, particularly in low-income and middle-income
countries (LMICs)....
thelancet.com
"Only 32% of countries have policies explicitly including neurological disorders, and even fewer have legislation safeguarding patients’ human rights." thelancet.com/journals/lan...
Ian McKeith on dementia with dementia with Lewy bodies
Podcast Episode · The Lancet Neurology in conversation with · 12/11/2025 · 16m
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And in our latest podcast, we talk with Ian McKeith (Newcastle, UK) about key milestones, breakthroughs, and what the future might hold for understanding and treating dementia with Lewy bodies
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Reposted by The Lancet
Advances in Dementia with Lewy Bodies
Lewy body dementia is a neurodegenerative disorder characterised by the accumulation of misfolded α-synuclein. The disease can disrupt cognitive function, motor function, autonomic regulation, and sle...
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ICYMI: a Series of papers in our December issue highlights advances in basic and clinical research that have the potential to transform management of Lewy body dementia: www.thelancet.com/series-do/de...
Reposted by The Lancet Neurology
The Lancet
@thelancet.com
· 26d
📢 Don't miss it!
Watch our webinar to discover the importance of innate immunity in the development of neurological diseases, including interferonopathies, multiple sclerosis, and neurodegenerative diseases.
▶️ Watch now: hubs.li/Q03NdV5c0
#neurology #brainhealth
Watch our webinar to discover the importance of innate immunity in the development of neurological diseases, including interferonopathies, multiple sclerosis, and neurodegenerative diseases.
▶️ Watch now: hubs.li/Q03NdV5c0
#neurology #brainhealth
Attending the 2025 European Headache Congress? Heather Brown, Senior Editor @thelancetneuro.bsky.social, invites you to reach out with enquiries. Explore our scope, reach & impact, commitment to publishing excellence, & more: hubs.li/Q03BKqbs0
ICYMI: our December issue includes an overview of the evidence for blood and CSF biomarkers, including their potential clinical applications, in patients with multiple sclerosis. Read the Review by Tanuja Chitnis and colleagues here:
www.thelancet.com/journals/lan...
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Reposted by The Lancet Neurology
The Lancet
@thelancet.com
· Nov 19
📢 Don't miss our upcoming webinar with Cell Press!
Register now to join the discussion and explore how innate immunity shapes neurological diseases by examining its protective and harmful roles in the brain.
👉 Register: hubs.li/Q03NdTNP0
#neurology #brainhealth #alzheimers #multiplesclerosis
Register now to join the discussion and explore how innate immunity shapes neurological diseases by examining its protective and harmful roles in the brain.
👉 Register: hubs.li/Q03NdTNP0
#neurology #brainhealth #alzheimers #multiplesclerosis
Global, regional, and national burden of headache disorders, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Headache disorders, in particular migraine, continue to be a major global health challenge, emphasising the need for effective management and prevention strategies. Much headache-attributed burden could be averted or eliminated by avoiding overuse of medication (including over-the-counter medication), underscoring the importance of public education.
thelancet.com
ICYMI: new analysis from the Global Burden of Disease Study 2023 presents updated results on headache-attributed burden from 1990 to 2023, along with clinical and public health implications: thelancet.com/journals/lan...
Ian McKeith on dementia with dementia with Lewy bodies - The Lancet Neurology in conversation with
In this episode, host Antonia Eisenkoeck, speaks with Ian McKeith, Emeritus Professor of Old Age Psychiatry at Newcastle University, UK. They delve into the history of dementia with Lewy bodies resear...
www.buzzsprout.com
LISTEN: In the latest podcast episode, host Antonia Eisenkoeck speaks with Ian McKeith. They delve into the history of dementia with Lewy bodies research, highlighting key milestones and breakthroughs: www.buzzsprout.com/1391383/epis...
Advances in Dementia with Lewy Bodies
Lewy body dementia is a neurodegenerative disorder characterised by the accumulation of misfolded α-synuclein. The disease can disrupt cognitive function, motor function, autonomic regulation, and sle...
www.thelancet.com
SERIES: A collection of three papers highlight the latest advancements in basic and clinical research that are transforming the approach to disease management in Lewy body dementia: www.thelancet.com/series-do/de...
Blood and CSF biomarkers for multiple sclerosis: emerging clinical applications
Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), chitinase-3-like
protein 1 (CHI3L1), and other protein assays are being developed as diagnostic or
prognostic biomarkers in mul...
thelancet.com
In a Review, Tanuja Chitnis and colleagues provide an overview of the emerging evidence from studies that have assessed blood and CSF biomarkers and their clinical associations in patients with multiple sclerosis: thelancet.com/journals/lan...
Lifetime and 10-year absolute risk of cognitive impairment in relation to amyloid PET severity: a retrospective, longitudinal cohort study
Lifetime and 10-year absolute risk for MCI and dementia among individuals who are
currently cognitively unimpaired increase with increasing biological severity of Alzheimer's
disease. This information...
thelancet.com
In their Article, Clifford Jack and colleagues compute lifetime and 10-year absolute risk of cognitive impairment as a function of continuous amyloid PET: thelancet.com/journals/lan...
Global, regional, and national burden of headache disorders, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Headache disorders, in particular migraine, continue to be a major global health challenge,
emphasising the need for effective management and prevention strategies. Much headache-attributed
burden cou...
thelancet.com
The latest analysis of data from the Global Burden of Disease Study 2023 presents updated results on headache-attributed burden from 1990 to 2023, along with clinical and public health implications: thelancet.com/journals/lan...
NEW ISSUE: Read the latest content on: Lewy bodies research, the global burden of headache disorders, brain amyloid and risk of cognitive impairment, biomarkers for multiple sclerosis, and more at:
thelancet.com/journals/lan...
thelancet.com/journals/lan...
Reposted by The Lancet Neurology
The Lancet
@thelancet.com
· Oct 24
Offline: “People have died”
The World Health Summit has proved itself the premier global health event of the year.
Under the banner “Taking responsibility for health in a fragmenting world”—symbolised
by a giant stage globe crac...
tinyurl.com
"Politicians may forget...Communities do not."
In his latest Offline, Richard Horton reflects on the recent World Health Summit, where global health leaders grappled with the aftermath of the US' sudden withdrawal of funding from @who.int: tinyurl.com/mr3bjs85
In his latest Offline, Richard Horton reflects on the recent World Health Summit, where global health leaders grappled with the aftermath of the US' sudden withdrawal of funding from @who.int: tinyurl.com/mr3bjs85
Reposted by The Lancet Neurology
The Lancet
@thelancet.com
· Oct 24
The UK is facing a pharma exodus, driven by claims that insufficient NHS investment threatens pharmaceutical innovation.
Yet, evidence suggests that the current pharma business model prioritises shareholder profits over innovation.
Find out more in an Editorial: tinyurl.com/n4pczpzx
Yet, evidence suggests that the current pharma business model prioritises shareholder profits over innovation.
Find out more in an Editorial: tinyurl.com/n4pczpzx