The Lancet Neurology
@thelancetneuro.bsky.social
The Lancet Neurology is the leading journal in clinical neurology. We publish articles and reviews that advocate change in, or illuminate, clinical practice.
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NEW ISSUE: Read the latest content on HSV encephalitis, autosomal dominant Alzheimer's disease, acute ischaemic stroke, vaccination and dementia, prion diseases, and more at: thelancet.com/journals/lan...
Intravenous tenecteplase for acute ischaemic stroke within 24 h due to basilar artery occlusion
Basilar artery occlusion is a devastating condition with dismal prognosis and constitutes
the most severe presentation of acute ischaemic stroke due to large-vessel occlusion.1
Randomised evidence on ...
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With further discussion in a linked Comment: www.thelancet.com/journals/lan...
Reposted by The Lancet
Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5): a multicentre, prospective, randomised, open-label, blinded-endpoint, superiority, phase 3 trial
In this trial involving Chinese patients with ischaemic stroke due to basilar artery
occlusion, tenecteplase within 24 h after stroke onset improved functional outcome
compared with standard medical t...
www.thelancet.com
Online first @thelancet.com: the TRACE-5 phase 3 trial of tenecteplase versus standard medical treatment for ischaemic stroke caused by basilar artery occlusion www.thelancet.com/journals/lan...
Reposted by The Lancet Neurology, The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
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Discover The Lancet’s Clinical Resources: spkl.io/63324AsfDu
Reposted by The Lancet Neurology
End-to-end translation in neuroscience
The British Neuroscience Association (BNA) Festive Symposium 2025, held on December
9, 2025, set out to examine what it really means for neuroscience to reach society.
Rather than focussing on discove...
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People are living with disease while waiting for research to become care. The @britishneuro.bsky.social Festive Symposium highlighted that the ethical duty of translational neuroscience now extends beyond discovery itself. Delivery is part of the science.
🔗 www.thelancet.com/journals/ebi...
🔗 www.thelancet.com/journals/ebi...
Testing early haemostatic therapy for acute intracerebral haemorrhage
The clinical severity, narrow time window to reduce bleeding, and variable care pathways
for patients with spontaneous (non-traumatic) intracerebral haemorrhage (ICH) are
enormous challenges to be ove...
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With linked Comment: www.thelancet.com/journals/lan...
Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial
Recombinant factor VIIa administered within 2 h of ICH onset slowed haematoma growth,
but did not improve functional outcomes and showed a small increased risk of life-threatening
thromboembolic compl...
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Online @thelancet.com, the FASTEST trial of recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset: www.thelancet.com/journals/lan...
Plus linked Comment highlighting limitations and remaining uncertainties: www.thelancet.com/journals/lan...
Epileptic activity in Alzheimer's disease: emerging insights and therapeutic implications
An estimated 60% of patients with Alzheimer's disease develop epilepsy or subclinical
epileptiform activity over the course of the disease. New-onset seizures in cognitively
healthy adults also increa...
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ONLINE FIRST: a Personal View on new insights into the intersection of epileptic activity and Alzheimer's disease www.thelancet.com/journals/lan...
The potential for dementia prevention through vaccination
The need to prevent dementia is compelling, with 150 million people projected to be
living with dementia by 2050.1 Efforts to prevent dementia have focused on potentially
modifiable risk factors that ...
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With further discussion of the findings and their potential implications in a linked Comment: www.thelancet.com/journals/lan...
Herpes zoster vaccination and incident dementia in Canada: an analysis of natural experiments
This analysis of natural experiments provides evidence, which is more likely to reflect
a causal relationship than previous evidence from more standard observational data
analyses, that herpes zoster ...
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In our February issue: @pascalge.bsky.social and colleagues compare new dementia diagnoses between vaccine-eligible and vaccine-ineligible birth cohorts to investigate whether herpes zoster vaccination might be associated with reduced dementia risk
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www.thelancet.com/journals/lan...
Reposted by The Lancet, The Lancet Neurology, The Lancet Diabetes Endocrinology
🚀 Just launched – our new #goldopenaccess journal on medical imaging and theranostics!
Learn more about the journal’s mission and explore related content from The Lancet Group today: hubs.li/Q041CgFF0
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Learn more about the journal’s mission and explore related content from The Lancet Group today: hubs.li/Q041CgFF0
#medsky
With further discussion of door-in-door-out times and stroke outcomes in a linked Comment: www.thelancet.com/journals/lan...
Door-in-door-out times and outcomes in patients with acute ischaemic stroke transferred for endovascular therapy in the USA: a retrospective cohort study
Longer DIDO times were strongly associated with lower rates of endovascular therapy,
higher rates of complications, and worse functional outcomes. System-level strategies
to minimise DIDO time are ess...
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In our February issue: a new study investigating the impact of door-in-door-out time (time from arrival to discharge at the presenting emergency department) on outcomes after acute ischaemic stroke www.thelancet.com/journals/lan...
Incidence and spatial variation of Parkinson's disease in the Netherlands (2017–2022): a population-based study
The multifaceted algorithm offers a robust PD case ascertainment tool that allowed
for a comprehensive nationwide assessment of PD incidence. In the Netherlands, this
new approach uncovered regional d...
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Online first in @lancetrh-europe.bsky.social: a comprehensive nationwide assessment of Parkinson's disease incidence in the Netherlands, aiming to generate insights into the spatial and demographic patterns of risk www.thelancet.com/journals/lan...
With discussion of the DexEnceph trial's insights and limitations in a linked Comment: www.thelancet.com/journals/lan...
Safety and efficacy of adjunct dexamethasone in adults with herpes simplex virus encephalitis in the UK (DexEnceph): a multicentre, observer-blind, randomised, phase 3, controlled trial
In adults with HSV encephalitis, dexamethasone plus aciclovir had a satisfactory safety
profile but did not improve verbal memory score compared with aciclovir alone. Given
the established role of cor...
thelancet.com
In our February issue: @runningmadprof.bsky.social and colleagues report the results of the DexEnceph trial, assessing the safety and efficacy of adding dexamethasone to aciclovir treatment for adults with herpes simplex virus encephalitis: thelancet.com/journals/lan...
...and in a letter from the Global PROMS Initiative
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www.thelancet.com/journals/lan...
The value of patient experience in multiple sclerosis research
The number of therapies approved to treat multiple sclerosis has grown substantially
over the past 20 years, yet many people living with the disease continue to have symptoms
that are not adequately c...
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"recognition is growing that patient-reported outcomes (PROs) must be integral to drug development, to ensure that therapies meet patients’ needs."
Read more on PROs for multiple sclerosis in our latest editorial...
www.thelancet.com/journals/lan...
Read more on PROs for multiple sclerosis in our latest editorial...
www.thelancet.com/journals/lan...
Multimedia | Podcasts | In conversation with | The Lancet Neurology
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plus PODCAST: in the latest episode of The Lancet Neurology In Conversation With, Inga Zerr and Simon Mead share their insights on prion diseases with our Editor-in-Chief Elena Becker-Barroso: podcasts.apple.com/gb/podcast/t...
open.spotify.com/show/0dY5qiz...
thelancet.com/multimedia/p...
open.spotify.com/show/0dY5qiz...
thelancet.com/multimedia/p...
Advances in biomarkers for diagnosis and prognosis of prion diseases
Seeded amplification assays have improved the accuracy of the diagnosis of prion diseases,
and blood-based diagnostic biomarkers are now close to clinical application. Although
clinical diagnosis can ...
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...and paper 2 covers biomarkers for diagnosis and prognosis of prion diseases www.thelancet.com/journals/lan...
Genetic causes and modifiers of prion diseases
Prion diseases are transmissible neurodegenerative diseases caused by misfolding of
prion protein (PrP). All inherited prion diseases, including genetic Creutzfeldt–Jakob
disease, Gerstmann–Sträussler...
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In our latest issue: a series of papers on prion diseases. Paper 1 covers genetic causes and modifiers... www.thelancet.com/journals/lan...
Blood pressure reduction and reperfusion therapy
Current evidence regarding blood pressure management before or after reperfusion therapies
for patients with acute ischaemic stroke consistently suggests inefficacy and likely
harm of intensive (targe...
www.thelancet.com
Plus a linked Comment on trials of blood pressure reduction and reperfusion therapy after stroke www.thelancet.com/journals/lan...
Early blood pressure management in acute ischaemic stroke before and after reperfusion treatment
Patients with acute ischaemic stroke often present with elevated blood pressure. Evidence
has emerged that challenges the longstanding recommendation across clinical guidelines
that blood pressure sho...
thelancet.com
In our latest issue: a Rapid Review of the latest evidence on the management of blood pressure before reperfusion therapy and after successful endovascular thrombectomy in people with acute ischaemic stroke thelancet.com/journals/lan...
With linked Comment on the implications of the trial for future Alzheimer's disease prevention research: www.thelancet.com/journals/lan...
In our latest issue: results from the API ADAD Colombia Trial, which evaluated the safety and efficacy of crenezumab in cognitively unimpaired mutation carriers at risk for autosomal-dominant Alzheimer's disease thelancet.com/journals/lan...