Sjoerd de Haan
@sjoerddehaan.bsky.social
Learning analytical chemistry in public 🧪
Building AI systems that transform measurement science
From custom GPU rigs to spectrometers | ML consultant → measurement innovation
Amsterdam | Currently: bacteria detection + Raman spectroscopy
Building AI systems that transform measurement science
From custom GPU rigs to spectrometers | ML consultant → measurement innovation
Amsterdam | Currently: bacteria detection + Raman spectroscopy
Reposted by Sjoerd de Haan
In the latest issue of Lab on a Chip:
Teach your microscope how to print: low-cost and rapid-iteration microfabrication for biology.
#OpenAccess from Olivier Pertz, Lucien Hinderling et al @olivierpertz.bsky.social @lhinderling.bsky.social.
Read now: pubs.rsc.org/en/content/a...
Teach your microscope how to print: low-cost and rapid-iteration microfabrication for biology.
#OpenAccess from Olivier Pertz, Lucien Hinderling et al @olivierpertz.bsky.social @lhinderling.bsky.social.
Read now: pubs.rsc.org/en/content/a...
Teach your microscope how to print: low-cost and rapid-iteration microfabrication for biology
The application of traditional microfabrication techniques to biological research is hindered by their reliance on clean rooms, expensive or toxic materials, and slow iteration cycles. We present an a...
pubs.rsc.org
August 6, 2025 at 9:33 AM
In the latest issue of Lab on a Chip:
Teach your microscope how to print: low-cost and rapid-iteration microfabrication for biology.
#OpenAccess from Olivier Pertz, Lucien Hinderling et al @olivierpertz.bsky.social @lhinderling.bsky.social.
Read now: pubs.rsc.org/en/content/a...
Teach your microscope how to print: low-cost and rapid-iteration microfabrication for biology.
#OpenAccess from Olivier Pertz, Lucien Hinderling et al @olivierpertz.bsky.social @lhinderling.bsky.social.
Read now: pubs.rsc.org/en/content/a...
That moment when your "weird" banana-shaped data reveals fundamental crystal physics 🤯
Simple UV-vis + quantum sims show gold nanorods grow with coupled dimensions.
scienceandmachines.com/daily/2025-0...
Simple UV-vis + quantum sims show gold nanorods grow with coupled dimensions.
scienceandmachines.com/daily/2025-0...
August 6, 2025 at 12:52 PM
That moment when your "weird" banana-shaped data reveals fundamental crystal physics 🤯
Simple UV-vis + quantum sims show gold nanorods grow with coupled dimensions.
scienceandmachines.com/daily/2025-0...
Simple UV-vis + quantum sims show gold nanorods grow with coupled dimensions.
scienceandmachines.com/daily/2025-0...
🧪 Applied gradient descent to gold nanorod and spectroscopy!
Decomposing UV/Vis absorption into basis functions reveals size distributions with banana-shaped correlations between length/diameter.
Short blog post: scienceandmachines.com/daily/2025-0...
#ML #nanoscience
Decomposing UV/Vis absorption into basis functions reveals size distributions with banana-shaped correlations between length/diameter.
Short blog post: scienceandmachines.com/daily/2025-0...
#ML #nanoscience
August 5, 2025 at 12:19 PM
🧪 Applied gradient descent to gold nanorod and spectroscopy!
Decomposing UV/Vis absorption into basis functions reveals size distributions with banana-shaped correlations between length/diameter.
Short blog post: scienceandmachines.com/daily/2025-0...
#ML #nanoscience
Decomposing UV/Vis absorption into basis functions reveals size distributions with banana-shaped correlations between length/diameter.
Short blog post: scienceandmachines.com/daily/2025-0...
#ML #nanoscience
Just wrote about working with experimental data in Python.
Used real quantum simulation data to show three ways to structure experimental grids.
scienceandmachines.com/data-driven-...
#Chemistry #Biology #Machinelearning
Used real quantum simulation data to show three ways to structure experimental grids.
scienceandmachines.com/data-driven-...
#Chemistry #Biology #Machinelearning
July 23, 2025 at 4:15 PM
Just wrote about working with experimental data in Python.
Used real quantum simulation data to show three ways to structure experimental grids.
scienceandmachines.com/data-driven-...
#Chemistry #Biology #Machinelearning
Used real quantum simulation data to show three ways to structure experimental grids.
scienceandmachines.com/data-driven-...
#Chemistry #Biology #Machinelearning
When you have 50 expensive nanoparticle spectra instead of 50,000 cat photos, what do you do?
Suddenly understanding distributions and uncertainty quantification isn't optional. Math matters in scientific machine learning.
scienceandmachines.com/knowledge-ba...
#spectroscopy #machinelearning
Suddenly understanding distributions and uncertainty quantification isn't optional. Math matters in scientific machine learning.
scienceandmachines.com/knowledge-ba...
#spectroscopy #machinelearning
July 18, 2025 at 10:29 AM
When you have 50 expensive nanoparticle spectra instead of 50,000 cat photos, what do you do?
Suddenly understanding distributions and uncertainty quantification isn't optional. Math matters in scientific machine learning.
scienceandmachines.com/knowledge-ba...
#spectroscopy #machinelearning
Suddenly understanding distributions and uncertainty quantification isn't optional. Math matters in scientific machine learning.
scienceandmachines.com/knowledge-ba...
#spectroscopy #machinelearning
Interactive exploration of gold nano rod UV/Vis spectra.
#spectroscopy #nanoscience
scienceandmachines.com/daily/2025-0...
#spectroscopy #nanoscience
scienceandmachines.com/daily/2025-0...
July 15, 2025 at 12:45 PM
Interactive exploration of gold nano rod UV/Vis spectra.
#spectroscopy #nanoscience
scienceandmachines.com/daily/2025-0...
#spectroscopy #nanoscience
scienceandmachines.com/daily/2025-0...
I'm 3 weeks into figuring out: "can machine learning + analytical chemistry impact biotech?"
www.scienceandmachines.com
www.scienceandmachines.com
July 10, 2025 at 8:00 AM
I'm 3 weeks into figuring out: "can machine learning + analytical chemistry impact biotech?"
www.scienceandmachines.com
www.scienceandmachines.com
July 9, 2025 at 2:29 PM
July 9, 2025 at 2:26 PM
How do you store and process spectrum data?
I need to store, process and display spectra for a demo.
Curious what software others use.
#spectroscopy
I need to store, process and display spectra for a demo.
Curious what software others use.
#spectroscopy
July 9, 2025 at 11:27 AM
How do you store and process spectrum data?
I need to store, process and display spectra for a demo.
Curious what software others use.
#spectroscopy
I need to store, process and display spectra for a demo.
Curious what software others use.
#spectroscopy
Just wrapped a organization's first ML project. Key insight: AI readiness isn't about the tech.
It's about:
📊 Data-driven decisions
🔄 Systematic evaluation
🧪 Experimentation culture
⚡ Speed infrastructure
Master these before AI arrives. Your competitors are waiting. Don't.
It's about:
📊 Data-driven decisions
🔄 Systematic evaluation
🧪 Experimentation culture
⚡ Speed infrastructure
Master these before AI arrives. Your competitors are waiting. Don't.
July 8, 2025 at 8:13 AM
Just wrapped a organization's first ML project. Key insight: AI readiness isn't about the tech.
It's about:
📊 Data-driven decisions
🔄 Systematic evaluation
🧪 Experimentation culture
⚡ Speed infrastructure
Master these before AI arrives. Your competitors are waiting. Don't.
It's about:
📊 Data-driven decisions
🔄 Systematic evaluation
🧪 Experimentation culture
⚡ Speed infrastructure
Master these before AI arrives. Your competitors are waiting. Don't.
Reposted by Sjoerd de Haan
Development of a low-cost, versatile, #Arduino -controlled #OpenSource #gas #chromatography system for #teaching #analytical #chemistry:
- cost: < US $100
- #Python #GUI
doi.org/10.1021/acs....
#DIYbio #DIYchem #lab #instruments #education #STEM #MINT #school #EDU #GC
- cost: < US $100
- #Python #GUI
doi.org/10.1021/acs....
#DIYbio #DIYchem #lab #instruments #education #STEM #MINT #school #EDU #GC
June 28, 2025 at 2:03 PM
Development of a low-cost, versatile, #Arduino -controlled #OpenSource #gas #chromatography system for #teaching #analytical #chemistry:
- cost: < US $100
- #Python #GUI
doi.org/10.1021/acs....
#DIYbio #DIYchem #lab #instruments #education #STEM #MINT #school #EDU #GC
- cost: < US $100
- #Python #GUI
doi.org/10.1021/acs....
#DIYbio #DIYchem #lab #instruments #education #STEM #MINT #school #EDU #GC
UV/Vis spectroscopy + 30 experiments + Extra Trees = predicting gold nanoparticle shapes
Sometimes small data + domain knowledge beats big data + brute force
New post: scienceandmachines.com/daily/2025-07-07/np-synthesis-ml
Sometimes small data + domain knowledge beats big data + brute force
New post: scienceandmachines.com/daily/2025-07-07/np-synthesis-ml
July 7, 2025 at 3:36 PM
UV/Vis spectroscopy + 30 experiments + Extra Trees = predicting gold nanoparticle shapes
Sometimes small data + domain knowledge beats big data + brute force
New post: scienceandmachines.com/daily/2025-07-07/np-synthesis-ml
Sometimes small data + domain knowledge beats big data + brute force
New post: scienceandmachines.com/daily/2025-07-07/np-synthesis-ml
💰 The $2M question in nanoparticle QC: How do you get TEM-quality data without TEM costs?
Today's deep dive revealed why this matters for biotech. 🧵
scienceandmachines.com/daily/2025-0...
Today's deep dive revealed why this matters for biotech. 🧵
scienceandmachines.com/daily/2025-0...
July 4, 2025 at 2:13 PM
💰 The $2M question in nanoparticle QC: How do you get TEM-quality data without TEM costs?
Today's deep dive revealed why this matters for biotech. 🧵
scienceandmachines.com/daily/2025-0...
Today's deep dive revealed why this matters for biotech. 🧵
scienceandmachines.com/daily/2025-0...
Wrote some notes on "Machine Learning Prediction of UV–Vis Spectra Features of Organic Compounds Related to Photoreactive Potential.”
scienceandmachines.com/daily/2025-0...
scienceandmachines.com/daily/2025-0...
June 30, 2025 at 7:01 PM
Wrote some notes on "Machine Learning Prediction of UV–Vis Spectra Features of Organic Compounds Related to Photoreactive Potential.”
scienceandmachines.com/daily/2025-0...
scienceandmachines.com/daily/2025-0...
Week 2 learning chem AI: Nature’s Colored Molecules and the Bathochromic Shift 🔵 → 🟢 → 🟡 → 🔴 .
Why study as ML person?
The next biotech revolution won't come from better models alone—it'll come from ML that designs & interprets experiments.
Notes: scienceandmachines.com/daily/2025-0...
Why study as ML person?
The next biotech revolution won't come from better models alone—it'll come from ML that designs & interprets experiments.
Notes: scienceandmachines.com/daily/2025-0...
June 28, 2025 at 6:38 AM
Week 2 learning chem AI: Nature’s Colored Molecules and the Bathochromic Shift 🔵 → 🟢 → 🟡 → 🔴 .
Why study as ML person?
The next biotech revolution won't come from better models alone—it'll come from ML that designs & interprets experiments.
Notes: scienceandmachines.com/daily/2025-0...
Why study as ML person?
The next biotech revolution won't come from better models alone—it'll come from ML that designs & interprets experiments.
Notes: scienceandmachines.com/daily/2025-0...
From data mining to experiment mining.
2 weeks into studying analytical chemistry, I want to make a prediction.
In 5 years we will not talk about just "models" but about dedicated (equipment + machine learning) experiments.
We will not mine data, but chemistry itself.
2 weeks into studying analytical chemistry, I want to make a prediction.
In 5 years we will not talk about just "models" but about dedicated (equipment + machine learning) experiments.
We will not mine data, but chemistry itself.
June 27, 2025 at 1:26 PM
From data mining to experiment mining.
2 weeks into studying analytical chemistry, I want to make a prediction.
In 5 years we will not talk about just "models" but about dedicated (equipment + machine learning) experiments.
We will not mine data, but chemistry itself.
2 weeks into studying analytical chemistry, I want to make a prediction.
In 5 years we will not talk about just "models" but about dedicated (equipment + machine learning) experiments.
We will not mine data, but chemistry itself.
🧪 Why is ethylene invisible but β-carotene orange? The bathochromic shift! Extended conjugation moves absorption from UV to visible light, creating color ✨
scienceandmachines.com/daily/2025-0...
#Chemistry #Science #DailyLearning #Spectroscopy
scienceandmachines.com/daily/2025-0...
#Chemistry #Science #DailyLearning #Spectroscopy
Conjugation in UV/Vis spectroscopy – Science and Machines
scienceandmachines.com
June 24, 2025 at 10:53 AM
🧪 Why is ethylene invisible but β-carotene orange? The bathochromic shift! Extended conjugation moves absorption from UV to visible light, creating color ✨
scienceandmachines.com/daily/2025-0...
#Chemistry #Science #DailyLearning #Spectroscopy
scienceandmachines.com/daily/2025-0...
#Chemistry #Science #DailyLearning #Spectroscopy
Orbital energies in UV/vis spectroscopy matter for understanding what ML models actually learn
scienceandmachines.com/daily/2025-0...
scienceandmachines.com/daily/2025-0...
Orbital Energies in UV/Vis Spectroscopy – Science and Machines
scienceandmachines.com
June 23, 2025 at 4:15 PM
Orbital energies in UV/vis spectroscopy matter for understanding what ML models actually learn
scienceandmachines.com/daily/2025-0...
scienceandmachines.com/daily/2025-0...
Reposted by Sjoerd de Haan
#Microscope Upcycling: Transforming legacy microscopes into #automated #cloud-integrated #imaging systems:
- #OpenSource automation: X-Y positioning, focus stacking, img acquisition/storage
- cost: US $300
doi.org/10.1016/j.oh...
#DIYbio #lab #instruments #microscopy #Raspi #PiCam #Python #OpenCV
- #OpenSource automation: X-Y positioning, focus stacking, img acquisition/storage
- cost: US $300
doi.org/10.1016/j.oh...
#DIYbio #lab #instruments #microscopy #Raspi #PiCam #Python #OpenCV
June 15, 2025 at 2:48 PM
#Microscope Upcycling: Transforming legacy microscopes into #automated #cloud-integrated #imaging systems:
- #OpenSource automation: X-Y positioning, focus stacking, img acquisition/storage
- cost: US $300
doi.org/10.1016/j.oh...
#DIYbio #lab #instruments #microscopy #Raspi #PiCam #Python #OpenCV
- #OpenSource automation: X-Y positioning, focus stacking, img acquisition/storage
- cost: US $300
doi.org/10.1016/j.oh...
#DIYbio #lab #instruments #microscopy #Raspi #PiCam #Python #OpenCV
Reposted by Sjoerd de Haan
🧪 TIL: Protein crystals mess with uv/vis.
Crystals scatter light, bend it, reflect it - and distort your spectroscopy data.
But here's the cool part: @ncaramel.bsky.social built a Python toolbox that automatically corrects for all the optical shenanigans.
Paper: journals.iucr.org/j/issues/202...
Crystals scatter light, bend it, reflect it - and distort your spectroscopy data.
But here's the cool part: @ncaramel.bsky.social built a Python toolbox that automatically corrects for all the optical shenanigans.
Paper: journals.iucr.org/j/issues/202...
The in crystallo optical spectroscopy toolbox
The rise of time-resolved macromolecular crystallography has been accompanied by renewed interest in companion biophysical characterization methods applicable to molecules both in solution and in crys...
journals.iucr.org
June 17, 2025 at 10:50 AM
🧪 TIL: Protein crystals mess with uv/vis.
Crystals scatter light, bend it, reflect it - and distort your spectroscopy data.
But here's the cool part: @ncaramel.bsky.social built a Python toolbox that automatically corrects for all the optical shenanigans.
Paper: journals.iucr.org/j/issues/202...
Crystals scatter light, bend it, reflect it - and distort your spectroscopy data.
But here's the cool part: @ncaramel.bsky.social built a Python toolbox that automatically corrects for all the optical shenanigans.
Paper: journals.iucr.org/j/issues/202...
Coming from ML background, trying to understand where UV/Vis + machine learning could make impact in biotech labs.
What papers do UV/Vis practitioners recommend for someone learning the intersection of analytical chemistry + ML in biotech?
#AnalyticalChemistry #UVVis #MachineLearning #Biotech
What papers do UV/Vis practitioners recommend for someone learning the intersection of analytical chemistry + ML in biotech?
#AnalyticalChemistry #UVVis #MachineLearning #Biotech
June 16, 2025 at 1:49 PM
Coming from ML background, trying to understand where UV/Vis + machine learning could make impact in biotech labs.
What papers do UV/Vis practitioners recommend for someone learning the intersection of analytical chemistry + ML in biotech?
#AnalyticalChemistry #UVVis #MachineLearning #Biotech
What papers do UV/Vis practitioners recommend for someone learning the intersection of analytical chemistry + ML in biotech?
#AnalyticalChemistry #UVVis #MachineLearning #Biotech
Writing diagrams as code with Tikz becomes so much easier with Claude.
And it still takes a lot of time...
And it still takes a lot of time...
May 22, 2025 at 8:13 AM
Writing diagrams as code with Tikz becomes so much easier with Claude.
And it still takes a lot of time...
And it still takes a lot of time...
Ai4bio conference in delft covered all scales in biotech. Impossible to summarize, this slide comes closest.
#biotech #machinelearning
#biotech #machinelearning
May 22, 2025 at 7:59 AM
Ai4bio conference in delft covered all scales in biotech. Impossible to summarize, this slide comes closest.
#biotech #machinelearning
#biotech #machinelearning