Neelima Thottappillil
@nthottappillil.bsky.social
Postdoctoral fellow @HopkinsMedicine| Studying blood vessels, stem cells and bone #HumaninSTEM | Alumnus @SCTIMST @EdinburghUniv | #FilledwithLaughter
Reposted by Neelima Thottappillil
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
November 20, 2025 at 1:23 PM
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Reposted by Neelima Thottappillil
Beautiful work on renal microvascular mural cells from @ondinecleaver.bsky.social
#SciArt
Tbx18+ ureteric stromal progenitor at E13.5 contributes to renal arterial/arteriolar NG2+ αSMA- mural cells & inner cortical NG2+ capillary pericyte
@devbiol.bsky.social
www.sciencedirect.com/science/arti...
#SciArt
Tbx18+ ureteric stromal progenitor at E13.5 contributes to renal arterial/arteriolar NG2+ αSMA- mural cells & inner cortical NG2+ capillary pericyte
@devbiol.bsky.social
www.sciencedirect.com/science/arti...
November 20, 2025 at 1:02 PM
Beautiful work on renal microvascular mural cells from @ondinecleaver.bsky.social
#SciArt
Tbx18+ ureteric stromal progenitor at E13.5 contributes to renal arterial/arteriolar NG2+ αSMA- mural cells & inner cortical NG2+ capillary pericyte
@devbiol.bsky.social
www.sciencedirect.com/science/arti...
#SciArt
Tbx18+ ureteric stromal progenitor at E13.5 contributes to renal arterial/arteriolar NG2+ αSMA- mural cells & inner cortical NG2+ capillary pericyte
@devbiol.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Neelima Thottappillil
Flow sorting of Perivascular Mesenchymal Progenitor Cells from human Adipose Tissue
Pericyte CD146+CD34−CD31−CD45−
Adventitial progenitor CD34+CD146−CD31−CD45−
What are those CD34+CD146+CD31−CD45− cells?😁
@nthottappillil.bsky.social #MethodsMolBiol 2024
link.springer.com/protocol/10....
Pericyte CD146+CD34−CD31−CD45−
Adventitial progenitor CD34+CD146−CD31−CD45−
What are those CD34+CD146+CD31−CD45− cells?😁
@nthottappillil.bsky.social #MethodsMolBiol 2024
link.springer.com/protocol/10....
November 2, 2025 at 10:02 PM
Flow sorting of Perivascular Mesenchymal Progenitor Cells from human Adipose Tissue
Pericyte CD146+CD34−CD31−CD45−
Adventitial progenitor CD34+CD146−CD31−CD45−
What are those CD34+CD146+CD31−CD45− cells?😁
@nthottappillil.bsky.social #MethodsMolBiol 2024
link.springer.com/protocol/10....
Pericyte CD146+CD34−CD31−CD45−
Adventitial progenitor CD34+CD146−CD31−CD45−
What are those CD34+CD146+CD31−CD45− cells?😁
@nthottappillil.bsky.social #MethodsMolBiol 2024
link.springer.com/protocol/10....
Reposted by Neelima Thottappillil
Microcalcification in Vasa Vasorum of Unruptured Intracranial Aneurysm
#SciArt #CaseReport
44 y/o ♂️ Likely #T2D
Calcified emboli in microvessels of cerebral arteries!?😆
Anne Robertson lab #SciAdv 2025
www.science.org/doi/10.1126/...
#SciArt #CaseReport
44 y/o ♂️ Likely #T2D
Calcified emboli in microvessels of cerebral arteries!?😆
Anne Robertson lab #SciAdv 2025
www.science.org/doi/10.1126/...
November 1, 2025 at 8:42 PM
Microcalcification in Vasa Vasorum of Unruptured Intracranial Aneurysm
#SciArt #CaseReport
44 y/o ♂️ Likely #T2D
Calcified emboli in microvessels of cerebral arteries!?😆
Anne Robertson lab #SciAdv 2025
www.science.org/doi/10.1126/...
#SciArt #CaseReport
44 y/o ♂️ Likely #T2D
Calcified emboli in microvessels of cerebral arteries!?😆
Anne Robertson lab #SciAdv 2025
www.science.org/doi/10.1126/...
Reposted by Neelima Thottappillil
#Atherosclerosis Epitranscriptomics
Cell type-specific dysregulation of m6A machinery in atherogenic phenotypes
#EndothelialCell ALKBH5
#SmoothMuscleCell WTAP
Mφ METTL3 YTHDF2
Re-analysis of scRNAseq Wirka's Nat Med 2019
pmc.ncbi.nlm.nih.gov/articles/PMC...
#THNO 2025
www.thno.org/v15p4785.htm
Cell type-specific dysregulation of m6A machinery in atherogenic phenotypes
#EndothelialCell ALKBH5
#SmoothMuscleCell WTAP
Mφ METTL3 YTHDF2
Re-analysis of scRNAseq Wirka's Nat Med 2019
pmc.ncbi.nlm.nih.gov/articles/PMC...
#THNO 2025
www.thno.org/v15p4785.htm
October 14, 2025 at 7:31 PM
#Atherosclerosis Epitranscriptomics
Cell type-specific dysregulation of m6A machinery in atherogenic phenotypes
#EndothelialCell ALKBH5
#SmoothMuscleCell WTAP
Mφ METTL3 YTHDF2
Re-analysis of scRNAseq Wirka's Nat Med 2019
pmc.ncbi.nlm.nih.gov/articles/PMC...
#THNO 2025
www.thno.org/v15p4785.htm
Cell type-specific dysregulation of m6A machinery in atherogenic phenotypes
#EndothelialCell ALKBH5
#SmoothMuscleCell WTAP
Mφ METTL3 YTHDF2
Re-analysis of scRNAseq Wirka's Nat Med 2019
pmc.ncbi.nlm.nih.gov/articles/PMC...
#THNO 2025
www.thno.org/v15p4785.htm
Reposted by Neelima Thottappillil
With no prior training, dogs can infer whether a toy is for tugging or fetching, even when the toys don't look alike. www.cell.com/current-biol...
@currentbiology.bsky.social
Eötvös Loránd University Claudia Fugazza, Andrea Sommese, Ádam Miklosi
@currentbiology.bsky.social
Eötvös Loránd University Claudia Fugazza, Andrea Sommese, Ádam Miklosi
September 18, 2025 at 3:00 PM
With no prior training, dogs can infer whether a toy is for tugging or fetching, even when the toys don't look alike. www.cell.com/current-biol...
@currentbiology.bsky.social
Eötvös Loránd University Claudia Fugazza, Andrea Sommese, Ádam Miklosi
@currentbiology.bsky.social
Eötvös Loránd University Claudia Fugazza, Andrea Sommese, Ádam Miklosi
Reposted by Neelima Thottappillil
As Vice Chair of the GRC Bones and Teeth, I am delighted to invite you to join us for our upcoming meeting, on January 25–30, 2026, at Hotel Galvez in Galveston, TX, a cherished venue for our conference.
We look forward to welcoming you to what is sure to be an exciting and memorable meeting!
We look forward to welcoming you to what is sure to be an exciting and memorable meeting!
September 11, 2025 at 6:40 PM
As Vice Chair of the GRC Bones and Teeth, I am delighted to invite you to join us for our upcoming meeting, on January 25–30, 2026, at Hotel Galvez in Galveston, TX, a cherished venue for our conference.
We look forward to welcoming you to what is sure to be an exciting and memorable meeting!
We look forward to welcoming you to what is sure to be an exciting and memorable meeting!
Reposted by Neelima Thottappillil
A new model of #TumorNecrosis👹
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
September 7, 2025 at 7:12 PM
A new model of #TumorNecrosis👹
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
Reposted by Neelima Thottappillil
In his memory, Western has opened an equity-based graduate scholarship. Please consider supporting his final initiative if you are able: www.westernconnect.ca/beier ; thank you for all the time you spent and laughs you shared with him. We love and miss him so much already. - The Beiers
July 24, 2025 at 3:09 PM
In his memory, Western has opened an equity-based graduate scholarship. Please consider supporting his final initiative if you are able: www.westernconnect.ca/beier ; thank you for all the time you spent and laughs you shared with him. We love and miss him so much already. - The Beiers
Reposted by Neelima Thottappillil
Hi all. Frank passed peacefully with the love of his family on July 18, 2025 in London, ON. He was a wonderful human being who shared much of his life with you. We could not have asked for a better father, grandfather, friend, colleague, or mentor. 1/
July 24, 2025 at 3:06 PM
Hi all. Frank passed peacefully with the love of his family on July 18, 2025 in London, ON. He was a wonderful human being who shared much of his life with you. We could not have asked for a better father, grandfather, friend, colleague, or mentor. 1/
Reposted by Neelima Thottappillil
#VascualarBiology2025
Annual Meeting of NAVBO and the Microcirculatory Society!!
Join us on Cape Cod in Massachusetts!
October 19-23, 2025
Conference Abstracts are due August 4, 2025 by 5:00 pm ET.
Visit the conference website for more,
Register, and/or to submit an abstract www.navbo.org/vb2025/
Annual Meeting of NAVBO and the Microcirculatory Society!!
Join us on Cape Cod in Massachusetts!
October 19-23, 2025
Conference Abstracts are due August 4, 2025 by 5:00 pm ET.
Visit the conference website for more,
Register, and/or to submit an abstract www.navbo.org/vb2025/
July 23, 2025 at 7:43 PM
#VascualarBiology2025
Annual Meeting of NAVBO and the Microcirculatory Society!!
Join us on Cape Cod in Massachusetts!
October 19-23, 2025
Conference Abstracts are due August 4, 2025 by 5:00 pm ET.
Visit the conference website for more,
Register, and/or to submit an abstract www.navbo.org/vb2025/
Annual Meeting of NAVBO and the Microcirculatory Society!!
Join us on Cape Cod in Massachusetts!
October 19-23, 2025
Conference Abstracts are due August 4, 2025 by 5:00 pm ET.
Visit the conference website for more,
Register, and/or to submit an abstract www.navbo.org/vb2025/
Reposted by Neelima Thottappillil
Member publication alert:
Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations
www.nature.com/articles/s41...
Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations
www.nature.com/articles/s41...
Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations - Scientific Reports
Scientific Reports - Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations
www.nature.com
May 18, 2025 at 8:16 PM
Member publication alert:
Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations
www.nature.com/articles/s41...
Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations
www.nature.com/articles/s41...
Reposted by Neelima Thottappillil
Connect with NAVBO on more platforms now !!
May 9, 2025 at 5:45 PM
Connect with NAVBO on more platforms now !!
Reposted by Neelima Thottappillil
What we’ll be talking about at #VascularDiscovery25: From Genes to Medicine.
What are you most excited for?
What are you most excited for?
April 22, 2025 at 2:27 PM
What we’ll be talking about at #VascularDiscovery25: From Genes to Medicine.
What are you most excited for?
What are you most excited for?
Fantastic sessions at Vascular Discovery 2025. More exciting that it’s in Baltimore!!! @ahascience.bsky.social
Welcome to Baltimore and #VascularDiscovery25! Repost and share what you’re looking forward to the most this week.
April 24, 2025 at 3:08 PM
Fantastic sessions at Vascular Discovery 2025. More exciting that it’s in Baltimore!!! @ahascience.bsky.social
Join the symposium to know more on Integrated transcriptomics of blood vessel by Prof Aaron W James and other latest findings from our lab!! @navbo.bsky.social
Please join us next Tuesday April 29th at 1 pm EST for our next Symposium on Precision Genomics: CRISPR and Single-Cell Technologies in Vascular Biology, featuring #AaronJames @bgcoonlab.bsky.social @chadweldy.bsky.social and moderated by @vsleekim.bsky.social !
Register here: tinyurl.com/yhcdr68a
Register here: tinyurl.com/yhcdr68a
April 24, 2025 at 2:41 PM
Join the symposium to know more on Integrated transcriptomics of blood vessel by Prof Aaron W James and other latest findings from our lab!! @navbo.bsky.social
Reposted by Neelima Thottappillil
Happening this Thurs Apr 10th at 1pm ET!! Join us for the #InFocusSession on Exploring Therapeutic Approaches in the Vasculature!! Speakers were selected from Abstracts submitted to VB2024! These sessions are NOT recorded so be sure to attend!! Register👉 shorturl.at/LkITp
April 7, 2025 at 5:58 PM
Happening this Thurs Apr 10th at 1pm ET!! Join us for the #InFocusSession on Exploring Therapeutic Approaches in the Vasculature!! Speakers were selected from Abstracts submitted to VB2024! These sessions are NOT recorded so be sure to attend!! Register👉 shorturl.at/LkITp
Reposted by Neelima Thottappillil
Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing @natimmunol.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing - Nature Immunology
Itkin et al. identify a role for Fli-1 in hematopoietic stem cell activation during regenerative hematopoiesis. They show that Fli-1 coordinates hematopoietic stem cells to stimulate niche-derived Not...
www.nature.com
February 25, 2025 at 5:58 PM
Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing @natimmunol.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Neelima Thottappillil
Vascular Cell Biology Gordon Conference - rescheduled to July 2025, co-chaired by our own @nicolilab.bsky.social
www.grc.org/vascular-cel...
www.grc.org/vascular-cel...
February 25, 2025 at 8:58 PM
Vascular Cell Biology Gordon Conference - rescheduled to July 2025, co-chaired by our own @nicolilab.bsky.social
www.grc.org/vascular-cel...
www.grc.org/vascular-cel...
Reposted by Neelima Thottappillil
#SpatialTranscriptomics #Visium #Xenium
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
February 13, 2025 at 9:09 PM
#SpatialTranscriptomics #Visium #Xenium
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
Reposted by Neelima Thottappillil
I have started an Orthopaedic Research Starter Pack! Link: go.bsky.app/61hCir6. I am happy to add people -- comment below to be added!
November 19, 2024 at 12:46 AM
I have started an Orthopaedic Research Starter Pack! Link: go.bsky.app/61hCir6. I am happy to add people -- comment below to be added!
Reposted by Neelima Thottappillil
Another example of the different results one gets from a Scanpy vs. Seurat analysis, in this case a Visium HD dataset from academic.oup.com/bioinformati...
13 vs. 20 clusters. And qualitatively different results, corroborating what we saw in biorxiv.org/content/10.1...
13 vs. 20 clusters. And qualitatively different results, corroborating what we saw in biorxiv.org/content/10.1...
November 25, 2024 at 6:10 PM
Another example of the different results one gets from a Scanpy vs. Seurat analysis, in this case a Visium HD dataset from academic.oup.com/bioinformati...
13 vs. 20 clusters. And qualitatively different results, corroborating what we saw in biorxiv.org/content/10.1...
13 vs. 20 clusters. And qualitatively different results, corroborating what we saw in biorxiv.org/content/10.1...
Reposted by Neelima Thottappillil
Amazing "pre-Christmas" gift for the Vascular Biology Community! What a treat!!! 💫 www.nature.com/articles/s41...
An organotypic atlas of human vascular cells - Nature Medicine
A vascular cell atlas integrating single-cell data of 19 organs and tissues from 62 donors identifies angiotypic and organotypic characteristics of endothelial and mural cells.
www.nature.com
November 22, 2024 at 11:11 AM
Amazing "pre-Christmas" gift for the Vascular Biology Community! What a treat!!! 💫 www.nature.com/articles/s41...
Reposted by Neelima Thottappillil
Interesting to #pericyte lovers www.jneurosci.org/content/44/4...
Atp13a5 Marker Reveals Pericyte Specification in the Mouse Central Nervous System
Perivascular mural cells including vascular smooth cells (VSMCs) and pericytes are integral components of the vascular system. In the central nervous system (CNS), pericytes are also indispensable for...
www.jneurosci.org
November 17, 2024 at 2:41 PM
Interesting to #pericyte lovers www.jneurosci.org/content/44/4...