Joao V. Rodrigues
@jrodrigues.bsky.social
Biochemist. Scientist at Generate Biomedicines. Shakhnovich lab@Harvard postdoc alumnus. Interested in enzymes, experimental evolution, cell-free protein synthesis, automation.
Reposted by Joao V. Rodrigues
Generate Biomedicines tested the first AI-designed COVID-19 antibody in humans.
In 51 healthy adults, the antibody GB-0669 was safe, lasted about 54 days in the body, and neutralized Omicron variants for at least two weeks, supporting Phase 2 trials.
www.medrxiv.org/content/10.1...
In 51 healthy adults, the antibody GB-0669 was safe, lasted about 54 days in the body, and neutralized Omicron variants for at least two weeks, supporting Phase 2 trials.
www.medrxiv.org/content/10.1...
First-in-Human Study of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix
Background Antibodies against the SARS-CoV-2 spike receptor-binding domain provided effective COVID-19 treatment until resistant variants emerged. GB-0669 is a half-life extended monoclonal antibody o...
www.medrxiv.org
October 10, 2025 at 10:59 AM
Generate Biomedicines tested the first AI-designed COVID-19 antibody in humans.
In 51 healthy adults, the antibody GB-0669 was safe, lasted about 54 days in the body, and neutralized Omicron variants for at least two weeks, supporting Phase 2 trials.
www.medrxiv.org/content/10.1...
In 51 healthy adults, the antibody GB-0669 was safe, lasted about 54 days in the body, and neutralized Omicron variants for at least two weeks, supporting Phase 2 trials.
www.medrxiv.org/content/10.1...
Estação de metro de Harvard sq (Cambridge, MA), 8 da manhã, 10 Junho dia de Portugal, cheira-me a sardinhas assadas! Serão saudades?
June 10, 2025 at 12:06 PM
Estação de metro de Harvard sq (Cambridge, MA), 8 da manhã, 10 Junho dia de Portugal, cheira-me a sardinhas assadas! Serão saudades?
Reposted by Joao V. Rodrigues
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
May 13, 2025 at 11:37 PM
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
Reposted by Joao V. Rodrigues
The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
Institut Pasteur decides to leave X
The Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...
www.pasteur.fr
January 16, 2025 at 9:18 AM
The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
Check out the putative MOA of Generate Biomedicines's GB-0895, our monoclonal antibody for optimally inhibiting TSLP, a cytokine that drives asthma symptoms like shortness of breath. www.youtube.com/watch?v=KyR4...
GB-0895 (anti-TSLP) Putative MOA Video
YouTube video by Generate:Biomedicines
www.youtube.com
January 13, 2025 at 2:00 PM
Check out the putative MOA of Generate Biomedicines's GB-0895, our monoclonal antibody for optimally inhibiting TSLP, a cytokine that drives asthma symptoms like shortness of breath. www.youtube.com/watch?v=KyR4...
Reposted by Joao V. Rodrigues
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism
doi.org/10.1101/2024...
doi.org/10.1101/2024...
December 14, 2024 at 11:09 AM
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism
doi.org/10.1101/2024...
doi.org/10.1101/2024...
Reposted by Joao V. Rodrigues
Big if true
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 25, 2024 at 6:50 AM
Big if true
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Joao V. Rodrigues
A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀
@chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz
www.biorxiv.org/content/10.1...
@chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz
www.biorxiv.org/content/10.1...
November 22, 2024 at 4:28 AM
A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀
@chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz
www.biorxiv.org/content/10.1...
@chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz
www.biorxiv.org/content/10.1...
Reposted by Joao V. Rodrigues
How do you tell bots apart from real people on this app?
For me it's seeing an obscene number of very niche and cryptic hash tags in their bio.
100% that's a scientist
For me it's seeing an obscene number of very niche and cryptic hash tags in their bio.
100% that's a scientist
November 19, 2024 at 11:50 PM
How do you tell bots apart from real people on this app?
For me it's seeing an obscene number of very niche and cryptic hash tags in their bio.
100% that's a scientist
For me it's seeing an obscene number of very niche and cryptic hash tags in their bio.
100% that's a scientist
Reposted by Joao V. Rodrigues
Bluesky tops 20M users, narrowing gap with Instagram Threads
Bluesky tops 20M users, narrowing gap with Instagram Threads
Bluesky, the social network and X competitor has been benefiting from a surge of departures from the Elon Musk-owned app formerly known as Twitter. Today, Bluesky has hit a major milestone: it’s topped 20 million users. What’s more, new data indicates the…
tcrn.ch
November 19, 2024 at 4:16 PM
Bluesky tops 20M users, narrowing gap with Instagram Threads
Reposted by Joao V. Rodrigues
Highly multiplexed design of an allosteric transcription factor to sense new ligands
doi.org/10.1038/s414...
doi.org/10.1038/s414...
November 19, 2024 at 12:22 PM
Highly multiplexed design of an allosteric transcription factor to sense new ligands
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Joao V. Rodrigues
The Virtual Lab, an AI-human research collaboration, was applied to design nanobody binders for recent variants of SARS-CoV-2.
The designed nanobodies were experimentally validated, revealing a range of functional nanobodies with promising profiles.
www.biorxiv.org/content/10.1...
The designed nanobodies were experimentally validated, revealing a range of functional nanobodies with promising profiles.
www.biorxiv.org/content/10.1...
The Virtual Lab: AI Agents Design New SARS-CoV-2 Nanobodies with Experimental Validation
Science frequently benefits from teams of interdisciplinary researchers. However, most scientists don't have access to experts from multiple fields. Fortunately, large language models (LLMs) have rece...
www.biorxiv.org
November 13, 2024 at 3:36 PM
The Virtual Lab, an AI-human research collaboration, was applied to design nanobody binders for recent variants of SARS-CoV-2.
The designed nanobodies were experimentally validated, revealing a range of functional nanobodies with promising profiles.
www.biorxiv.org/content/10.1...
The designed nanobodies were experimentally validated, revealing a range of functional nanobodies with promising profiles.
www.biorxiv.org/content/10.1...
Reposted by Joao V. Rodrigues
Já estou há algum tempo com actividade regular no BlueSky e ainda não vi ninguém a ser baleado na rua, ou a ficar paralisado, não vi dois jovens à porrada até um bater com a cabeça no chão, já não sei o que são posts ultra nacionalistas, não tenho sido ofendido… Isto não vai a lado nenhum.
November 16, 2024 at 10:08 AM
Já estou há algum tempo com actividade regular no BlueSky e ainda não vi ninguém a ser baleado na rua, ou a ficar paralisado, não vi dois jovens à porrada até um bater com a cabeça no chão, já não sei o que são posts ultra nacionalistas, não tenho sido ofendido… Isto não vai a lado nenhum.
Reposted by Joao V. Rodrigues
Heard at the conference bar: “How many starter packs are you part of?”
November 15, 2024 at 1:06 AM
Heard at the conference bar: “How many starter packs are you part of?”
Reposted by Joao V. Rodrigues
Dizem-me que está em acesso 🔒 porque também foi publicado em papel
Partilho com os primeiros pedidos via DM, basta deixarem o e-mail
Partilho com os primeiros pedidos via DM, basta deixarem o e-mail
O orçamento para a Ciência em Portugal não existe: lendo o OE e a nota explicativa é dolorosamente óbvio que o dinheiro é pouco, mal gasto e para "inovação"
A cada ano, uma oportunidade perdida
Grata à Teresa Firmino e @tiagoramalho.bsky.social por conversas e edições
www.publico.pt/2024/11/14/c...
A cada ano, uma oportunidade perdida
Grata à Teresa Firmino e @tiagoramalho.bsky.social por conversas e edições
www.publico.pt/2024/11/14/c...
Porque é que o Orçamento do Estado para a ciência é uma péssima notícia para o país?
Não só não estamos a aumentar o apoio à ciência e a convergir com outros países europeus, como estamos efectivamente e diminuí-lo e a ficar cada vez mais para trás.
www.publico.pt
November 15, 2024 at 10:16 AM
Dizem-me que está em acesso 🔒 porque também foi publicado em papel
Partilho com os primeiros pedidos via DM, basta deixarem o e-mail
Partilho com os primeiros pedidos via DM, basta deixarem o e-mail
Reposted by Joao V. Rodrigues
Bluesky adds 700,000 new members as users flee X after the US election | Bluesky | The Guardian
Bluesky adds 700,000 new members as users flee X after the US election
Social media platform has become a ‘refuge’ from the far-right activism on X, experts say, after Elon Musk teamed up with Donald Trump
buff.ly
November 12, 2024 at 9:05 AM
Bluesky adds 700,000 new members as users flee X after the US election | Bluesky | The Guardian
Reposted by Joao V. Rodrigues
I thought about putting together an ex-academic scientist starter pack, but I quit that too.
November 12, 2024 at 12:40 AM
I thought about putting together an ex-academic scientist starter pack, but I quit that too.
Reposted by Joao V. Rodrigues
The US is an outlier among wealthy democracies in having a government that, on average, continues to get older.
November 11, 2024 at 11:03 AM
The US is an outlier among wealthy democracies in having a government that, on average, continues to get older.
Reposted by Joao V. Rodrigues
2️⃣ Maud Leonora Menten 🇨🇦 (1879-1960) #womeninSTEM Canadian biochemist, known for her work in enzymology. With Michaelis, she developed an equation that explain the rate of reversible enzymatic reactions & substrate concentration, the Michaelis-Menten equation
definingmomentscanada.ca/insulin100/s...
definingmomentscanada.ca/insulin100/s...
October 20, 2023 at 11:14 AM
2️⃣ Maud Leonora Menten 🇨🇦 (1879-1960) #womeninSTEM Canadian biochemist, known for her work in enzymology. With Michaelis, she developed an equation that explain the rate of reversible enzymatic reactions & substrate concentration, the Michaelis-Menten equation
definingmomentscanada.ca/insulin100/s...
definingmomentscanada.ca/insulin100/s...
For decades, the simple ability to design oligos that bind to a specific DNA/RNA sequence has been key for unlocking so many secrets in Biology. What if we could also design proteins in whatever way we wanted? We are now one step closer - check out our recently published paper.
Illuminating protein space with a programmable generative model - Nature
Evolution has produced a range of diverse proteins, and now a generative model called Chroma can expand that set by allowing the user to design new proteins and protein complexes with desired pro...
www.nature.com
November 16, 2023 at 1:53 PM
For decades, the simple ability to design oligos that bind to a specific DNA/RNA sequence has been key for unlocking so many secrets in Biology. What if we could also design proteins in whatever way we wanted? We are now one step closer - check out our recently published paper.
It's only fit to share this as my first interaction on this platform.
“You can’t have meaningful and productive scientific collaboration on a platform run by a right-wing troll who denies science when its results are inconvenient to him and just simply to hear his audience cheer,” Bergstrom wrote'
www.latimes.com/business/sto...
www.latimes.com/business/sto...
Column: Scientists used to love Twitter. Thanks to Elon Musk, they're giving up on it
Scientists came to see Twitter as an indispensable tool for communicating with each other and the public. As X, it's turned into a source of scientific misinformation and lies.
www.latimes.com
September 4, 2023 at 2:12 AM
It's only fit to share this as my first interaction on this platform.