@ghaffarilab.bsky.social
Laboratory of Hematopoietic Stem Cells and Erythropoiesis @ Icahn School of Medicine at Mount Sinai
If you are interested in aging and stem cells, check out our newly published work in Cell Stem Cell, in collaboration with Mickaël Ménager and his team at Institut Imagine (Paris, France), on a lysosome-based strategy that reverses aging in blood-forming stem cells.
Online Now! Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells #stemcells
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
Arif et al. show that lysosomes in aged HSCs are hyperacidic and dysfunctional, and that lysosomal alterations are central to HSCs’ decline with age. cGAS-STING signaling, driven by misprocessed mtDNA, mediates inflammation in old HSCs. Notably, inhibition of v-ATPases restores lysosomal integrity, reduces inflammation, and improves aged HSCs’ function.
dlvr.it
December 3, 2025 at 8:03 PM
If you are interested in aging and stem cells, check out our newly published work in Cell Stem Cell, in collaboration with Mickaël Ménager and his team at Institut Imagine (Paris, France), on a lysosome-based strategy that reverses aging in blood-forming stem cells.