Rafał Marecki
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druidzaklinacz.bsky.social
Rafał Marecki
@druidzaklinacz.bsky.social
190 followers 780 following 10 posts
🩺 Physician 🧪 PhD candidate
🧠 Neurosteroids and psychedelics research
🧑🏻‍🏫 I educate high school students on depression, exam stress and getting help.
Białystok, Poland
he/him
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druidzaklinacz.bsky.social
Rafał Marecki @druidzaklinacz.bsky.social · Nov 16
Neurosteroids are metabolites of progesterone that, through the GABAA receptor, affect development, regeneration, and neuronal transmission. The link to the publication is in the next post.

#neuroscience #science #medicine #psychiatry #gynaecology #endocrinology #neurology
Reposted by Rafał Marecki
lasyiobywatele.bsky.social
Już jest! Mapa rębni #ZanimWytnąTwójLas aktualizacja 2025.
mapy.lasyiobywatele.pl/zanim-wytna-...
Aktualizacja oparta jest o dane prowizorium Lasów Państwowych 2025 oraz o analizy w oparciu o polecenia wydane przez MKiŚ. Niestety w 2025 wciąż będziemy tracić cenne lasy. Więcej info w komentarzach.
February 5, 2025 at 2:16 PM
druidzaklinacz.bsky.social
So... polish minister of national defence Władysław Kosiniak-Kamysz wants to make health education an elective course. Isn't it hilarious that he is a Doctor of Medicine and has a PhD in medical science (sic!)?
January 13, 2025 at 12:55 AM
Reposted by Rafał Marecki
djsmith90.bsky.social
New blog post I cobbled together for the Bristol Reproducibility Network

Ethical Academic Publishing: How to Make Academic Publishing Fairer, More Open and Less Wasteful

openresearchbristol.blogs.bristol.ac.uk/2024/09/23/e...
Ethical Academic Publishing: How to Make Academic Publishing Fairer, More Open and Less Wasteful – Open Research at Bristol
openresearchbristol.blogs.bristol.ac.uk
October 4, 2024 at 10:57 AM
Reposted by Rafał Marecki
artbymickeyg.bsky.social
Biologist Simona Kossak (seen here riding through Białowieża Forest on her Komar) is my new hero today.
November 16, 2024 at 3:25 PM
Reposted by Rafał Marecki
ihavi.bsky.social
Simona Kossak was a key figure in Polish ecology, dedicated to protecting the Białowieża Forest, one of Europe’s last ancient woodlands. For over 30 years, she lived alone in a modest cabin in the forest, without electricity or water, fully immersed in the wilderness she sought to protect.
Simona Kossak Alt text: A black-and-white photograph showing Simona Kossak lying on the floor with her eyes closed, appearing to rest peacefully beside a bed. On the bed, a large dog and a tame boar lay close together, creating an intimate scene of harmony between human and animals. The room is simply furnished, reflecting a rustic, natural lifestyle.
November 13, 2024 at 4:58 PM
Reposted by Rafał Marecki
adriaandthepriors.bsky.social
If you haven’t heard about her, I would like to introduce you to Simona Kossak- an extraordinary scientist, who fought to preserve the remnants of natural ecosystems in Poland and one of the last and the largest remaining part of primeval forest, Bialowieza.
The Real-Life Polish Dr. Dolittle, Simona Kossak
Simona Kossak, Polish larger-than-life zoopsychologist, can be easily compared to dr Dolittle for her skills in understanding animal tongue.
3seaseurope.com
September 7, 2024 at 7:33 PM
Reposted by Rafał Marecki
elderman.bsky.social
Simona Kossak (1943-2007) Polish biologist, ecologist, author, PhD in forestry, and uncompromising conservation activist
They called her a witch, because she chatted with animals and owned a terrorist-crow, who stole gold and attacked bicycle riders.
December 14, 2024 at 12:14 AM
Reposted by Rafał Marecki
sheencr.bsky.social
Brilliant and also very personal piece by @kityates.bsky.social on the HPV vaccine, the role of modelling in considering benefits and the links of HPV with several other cancers. 🧪
Why it makes sense to vaccinate boys against HPV
In the light of more good news about declining rates of death from cervical cancer, why do we vaccinate boys against the virus that causes it?
open.substack.com
December 2, 2024 at 8:37 AM
Reposted by Rafał Marecki
doctorblood.bsky.social
We humbly thank the reviewers for their suggestions. We would like to resubmit this improved manuscript for your consideration. #AcademicSky #MedSky
November 29, 2024 at 4:26 PM
druidzaklinacz.bsky.social
Did you know that Poland has its own points system for scientific journals? It scores from 0 to 200 and only depends on the minister of science and higher education's whim. For example Nature has 200 points. When Czranek was leaving the office he raised scores for some journals even for 180 points.
November 30, 2024 at 10:12 AM
Reposted by Rafał Marecki
drjonlim.bsky.social
🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
Reposted by Rafał Marecki
maryfernando.bsky.social
Please consider following @geoffypjohnston.bsky.social

He writes investigative, international stories, rarely told elsewhere, as one of the few left in that dying breed of independent journalists.*

*He’s not personally dying, so 😅 because I consider him a friend.

#Journalists
#CanadaSky
geoffypjohnston.bsky.social Geoffrey P Johnston😎🇨🇦🇺🇦 @geoffypjohnston.bsky.social · Nov 29
“If Russia is allowed to succeed in Ukraine, its aggressive appetite will continue to grow. This is highly relevant to Canada, which is Russia’s neighbour in the Arctic.”—Ukrainian Consul General of Toronto @OlehNikolenko_‬⁩

www.thewhig.com/opinion/russ...
Russia wages war with lies and violence
Vladimir Putin’s Russia is an authoritarian state that uses kinetic warfare, propaganda, and disinformation to attack neighbouring countries and destabilize the world’s democracies.
www.thewhig.com
November 29, 2024 at 11:59 AM
Reposted by Rafał Marecki
xiaoxuanlei.bsky.social
🌟 New Research Alert! 🌟
Excited to share our latest work (accepted to NeurIPS2024) on understanding working memory in multi-task RNN models using naturalistic stimuli!: with @takuito.bsky.social and @bashivan.bsky.social
#tweeprint below:
November 28, 2024 at 4:41 PM
Reposted by Rafał Marecki
drewberry.bsky.social
Happy Holliday Junction for those who celebrate
November 29, 2024 at 3:37 AM
Reposted by Rafał Marecki
daphnezohar.bsky.social
New review in Nature Neuroscience highlights the neuroplastic activity of rapidly acting antidepressants, including allopregnanolone www.nature.com/articles/s41... #psysky #neurosky
November 27, 2024 at 10:47 PM
Reposted by Rafał Marecki
castltrastondrs.bsky.social
#neurosteroids replacement therapy (NRT) with GABA-A receptor-modulating allopregnanolone (brexanolone) PPD affects 500000 women in 🇺🇸 annually. BX is 1st #neurosteroid approved for PPD and marks a significant milestone in the field of #neuropsychopharmacology

www.cell.com/trends/molec...
BX’s mechanism in postpartum depression (PPD) involves elevating brain allopregnanolone (AP), which may decrease significantly at postpartum, back to third trimester levels. AP acts as a preferential allosteric modulator and direct activator of extrasynaptic δGABA-ARs, which causes persistent hyperpolarization of neurons and shunts network hyperexcitability. Although the precise binding location is unclear, both activation and potentiation functions of AP apparently proceed from a single interfacial binding site, specifically at the α-subunit lipid interface. AP enhances the receptor function by binding to ‘neurosteroid binding’ sites, which are distinct from sites for GABA and benzodiazepines. Based on their location and kinetics, GABA-ARs are stratified into two groups. Synaptic receptors (α1β2γ2 subunits) mediate phasic inhibition in response to presynaptic release of GABA, while extrasynaptic receptors (α4β2δ subunits) primarily contribute to tonic inhibition in response to ambient
January 4, 2024 at 11:59 AM
Reposted by Rafał Marecki
mathieumolimard.bsky.social
La migration des scientifiques sur BlueSky prend forme. Bel article dans #science
www.science.org/content/arti...
Like ‘old Twitter’: The scientific community finds a new home on Bluesky
After recent changes to Elon Musk’s X, a gradual migration turns into a stampede
www.science.org
November 27, 2024 at 7:54 AM
druidzaklinacz.bsky.social
My friend just published her final paper, which will be included in her PhD thesis. She's researched the diagnostic utility of selected matrix metalloproteinases in patients with ovarian carcinoma. I hope you'll find this interesting 🥰

#gynaecology #cancers #science
www.mdpi.com/2072-6694/16...
Diagnostic Utility of Metalloproteinases from Collagenase Group (MMP-1, MMP-8 and MMP-13) in Biochemical Diagnosis of Ovarian Carcinoma
Background: Ovarian carcinoma (OC) has an unfavorable prognosis due to lack of screening and an asymptomatic course. New diagnostic methods are being sought to enable earlier diagnosis of this conditi...
www.mdpi.com
November 27, 2024 at 9:42 AM
Reposted by Rafał Marecki
drnancypadilla.bsky.social
1/✨ New paper in #eNeuro! We looked at how dominance behaviors vary across mouse strains—turns out, it’s not one-size-fits-all!
Comparing CD1 & C57 male mice, we found strain-specific dominance behaviors that could change how we study social hierarchy in the lab…🧵
Paper here: tinyurl.com/bdeuf6s9
diagrams of Behavioral assays tested
November 25, 2024 at 5:23 PM
Reposted by Rafał Marecki
danjgale.bsky.social
This is a really great paper and a joy to read: www.nature.com/articles/s41...

And, as always, it's great to see surfplot (surfplot.readthedocs.io/en/latest/) in the wild!
The cell-type underpinnings of the human functional cortical connectome - Nature Neuroscience
Here Zhang et al. establish multiscale relationships that link postmortem cell-type distributions with the in vivo functional organization of the human cerebral cortex, as assessed through functional ...
www.nature.com
November 22, 2024 at 4:23 PM
Reposted by Rafał Marecki
peterdkramer.bsky.social
It's been almost 20 years since the FDA required a black-box warning on product labels & advertising, alerting doctors & patients that antidepressants can cause suicidality in adolescents. A new compilation of subsequent research finds that the action caused a dramatic increase in deaths by suicide.
November 21, 2024 at 3:22 PM
Reposted by Rafał Marecki
walaszek.medsky.social
This infographic from the NIA could be a helpful teaching tool for people living with #dementia and their families and caregivers.

#medsky #geronsky

www.nia.nih.gov/health/alzhe...
Understanding different types of dementia: Alzheimer's disease, frontotemporal dementia, Lewy body dementia, vascular dementia. What is happening in the brain? Symptoms. Typical Age of Diagnosis. Diagnosis. Treatment.
November 19, 2024 at 2:15 PM
Reposted by Rafał Marecki
biorxiv-neursci.bsky.social
Sertraline modulates hippocampal plasticity and learning via sigma 1 receptors, cellular stress and neurosteroids https://www.biorxiv.org/content/10.1101/2024.01.23.576911v1
Sertraline modulates hippocampal plasticity and learning via sigma 1 receptors, cellular stress and neurosteroids https://www.biorxiv.org/content/10.1101/2024.01.23.576911v1
In addition to modulating serotonin transport, selective serotonin reuptake inhibitors (SSRIs) have
www.biorxiv.org
January 24, 2024 at 11:16 PM