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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 30

Dr Bilgili showed us the outcomes after OHTx divided by need of ECMO at 72 hours post surgery. ECMO need at 72 hours greatly worsens survival.

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 30

Dr Huang shows pre and post allocation change status change in immunosuppression and outcomes among multi-organ transplant.

Super interesting data. @ishlt.bsky.social #ISHLT2025

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 30

Dr Elbert Heng shows amazing study on survival of patients with ACHD receiving OHTx vs multiorgan transplant alone.

❤️ and 🫁 carry the worse survival so far.
@ishlt.bsky.social #ISHLT2025

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 30

Dr Paula Ramirez shows us their new predictive models to discriminate if ❤️ and kidney transplant is superior to kidney after ❤️. Beautiful work which can help change clinical practice at #ISHLT2025 @ishlt.bsky.social

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 30

Amazing work presented from Dr Topkara who developed a kidney risk score which predicts the risk for AKI/HD after ❤️ transplant! High AUC, higher than eGFR alone!

#ISHLT2025 @ishlt.bsky.social

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 30

Dr Hussain showed us a single center experience of Fontain patients receiving ❤️ transplant. Should they get a liver as well? Seems like all 24 of them had recovery of the liver function after transplant without needing a a new liver.

Great science at #ISHLT2025 @ishlt.bsky.social

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 30

Finally we talk about induction with Dr Barten. To induce or not to induce? This is the dilemma!

And Dr Carboni showed us how AI can be implemented in helping us with HLA matching.

Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 30

It’s AB0ut time we talk with Dr Aversa about AB0! Super interesting case of an 0 patient receiving nonA1 🫁 transplant with no signs of rejections.

Incredible science showed at #ISHLT2025 @ishlt.bsky.social

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 30

Followed by Dr Guillaime Coutance guiding us through PRAs. Which antibodies should we look for and how to measure???

Dr Lyster showed us what to do with highly sensitised patients pre and post transplant.

#ISHLT2025

Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 30

And last day at #ISHLT2025 we go through the consensus statement with Dr Annette Jackson. Amazing talk on the use of antibodies in transplant.

@ishlt.bsky.social

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 29

Did you get the reference?

Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 29

🎯 Dr. Tomas Pulido presented Out of the woods: High-altitude PAH. This subset of PAH is seen frequently in certain areas of south America and tend to improve with meds and moving to low altitude areas.

Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 29

🎯 Dr Valentina Stosor presented Shake it Off: HIV associated PAH. HIV infection induces changes in the PA other than from direct infection. Drugs interactions are frequent between PA vasodilators and ART.

Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 29

🎯 Dr Camila Loureiro presented I forgot that you existed: Schistosomiasis-Associated pulmonary arterial hypertension. Schistosoma is extremely frequent in certain areas of Africa, Asia and Brazil. We dipped dig on the treatments and diagnosis of such a rare subset of disease.

Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 29

🎯 Dr Hooman Poor presented Bad Blood: Pulmonary Hypertension, Hematologic disorder and Bone Marrow Transplant. Sickle cell, dasatinib associated PAH and mieloproliferative disease

Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 29

🎯 Dr Arun Jose presented: When the liver is the source of evil: porto-pulmonary HTN and liver transplantation.
PoP-PH is different from Hepato-pulmonary syndrome, which tends to regress after liver transplant. Liver transplant can improve PoP-PH though PH can persist.

Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 29

This morning at ISHLT I’m sensing a theme, let’s see if any of you catch on that. Rare causes of PH.
@ishlt.bsky.social
#PAH
#PH
#Rightventricle
#rare

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 29

🎯 Dr Arun Jose presented: When the liver is the source of evil: porto-pulmonary HTN and liver transplantation.
PoP-PH is different from Hepato-pulmonary syndrome, which tends to regress after liver transplant. Liver transplant can improve PoP-PH though PH can persist.

Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 28

We finish with a great talk from the amazing @nickbruin.bsky.social about the Delphi consensus.

Refer early and often
Reassess your patient. 🫁 transplant save lives and improves quality of life in PAH

#PAH #PH #lungtransplant #ISHLT2025
@ishlt.bsky.social

onlinelibrary.wiley.com/doi/full/10....

Approach to Lung Transplantation in Pulmonary Arterial Hypertension: A Delphi Consensus on Behalf of the Transplant Task Force of the Pulmonary Vascular Research Institute

Lung transplantation is indicated for selected patients with advanced pulmonary arterial hypertension (PAH). We used a modified Delphi process to develop recommendations on care of patients with PAH ...

onlinelibrary.wiley.com

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 28

What is the role of MCS in PAH and cardiogenic shock?

1) patient selection

2) choose the RIGHT access

3) have an exit strategy in view

4) start PH therapies

5) consider transplant

These are few of the points we discussed today with Dr Sommer @ishlt.bsky.social

#ISHLT #PAH #PH

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 28

What can you do when a patient with PH land in the ICU with Shock?

Dr Mads Andersen walks us through

Preload treatment
Inotropes and its use
Afterload for PH

Important talk @ishlt.bsky.social #ISHLT2025 #PH

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 28

And from the Right Ventricle- Right atria interaction we move to the complex relationship between heart - kidneys and lungs in PH with an amazing talk from Dr. Rosenkranz.

#ISHLT2025 #PAH #PH
@ishlt.bsky.social

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 28

Today we dig deep in the pathophys of PH #ISHLT2025 with Dr Frances De Man on pressure loop of the RA.

Super interesting discussion on what happens to myocites in the right atrium.

@ishlt.bsky.social #PAH #PH

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Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 27

We finished with Dr David Jenkins and CTEPH talks.

When confirmed CTEPH we should ask:

🟢is patient operable? If YES PTE
NO?

🟢Can we do BPA?
NO?

🟢Riociguat

New direction? Can we combine such treatments for high risk patients?

Dr Matteo Fabbri @drmatteofabbri.bsky.social · Apr 27

We also talked about group 3 PH with Dr Shlobin Oksana. The different pathophysiology of it and possible treatment options.

Differentiate between:

🟢COPD-PH
🟢CPFE-PH
🟢ILD-PH

More studies are needed with better characterisation of PFTs for therapeutic target.