Dan Johnson
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danmjohnson.bsky.social
Dan Johnson
@danmjohnson.bsky.social
910 followers 670 following 35 posts
Researcher in cardiac (electro)physiology
Lecturer at The Open University

#Springboard Academy of Medical Sciences

Chair ESC WGCCE
#SoMe @jmccplus.bsky.social

Dad
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Reposted by Dan Johnson
jmccplus.bsky.social
On your way to #AHA or just looking for some weekend reading?

Check out the latest paper from Warren et al who uncovered region-specific metabolic and signalling changes in the endocardium vs epicardium in a mini-pig model of #HCM 🫀🫀

sciencedirect.com/science/arti...

#CardioSky #AnimalModel
Signaling pathway alterations in hearts of a porcine model harboring a β-myosin heavy chain (MYH7-R403Q) gene variant
The disease-causing myosin variant (MYH7-403Q) is linked to hypertrophic cardiomyopathy (HCM). We carried out a research study of signaling pathways i…
sciencedirect.com
November 7, 2025 at 3:46 PM
Reposted by Dan Johnson
jmccplus.bsky.social
New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology

sciencedirect.com/science/arti...

#CardioSky
YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs
The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeo…
sciencedirect.com
November 3, 2025 at 12:47 PM
Reposted by Dan Johnson
jmccplus.bsky.social
We often treat #diabetes and #heart #disease separately — but they’re connected🫀.

A recent study from Srinivas, Alluri et al. shows that removing CHOP in β-cells protects against both metabolic dysfunction and cardiac fibrosis in T2D mice.

sciencedirect.com/science/arti...

#CardioSky #NewPaper
Deletion of CHOP in beta cell protects mice from cardiovascular complications in type 2 diabetes: evidence from a pre-clinical mouse model
Cardiovascular complications are the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D), which is recognized as a major i…
sciencedirect.com
October 30, 2025 at 1:52 PM
Reposted by Dan Johnson
jmccplus.bsky.social
🫀 New in JMCC Plus!

Age, sex & vessel region shape vasomotor function in the descending thoracic #aorta — with #endothelial integrity & relaxation declining with age.

Want to know more- check out Saemann et al.:

sciencedirect.com/science/arti...

#CardioSky @jmccardiology.bsky.social
Age, sex, and vessel region affect the vasomotor function and gene expression signature of the aorta in mice
Vascular aging is associated with endothelial dysfunction, changes in vascular elasticity or stiffness, and the prevalence of cardiovascular diseases.…
sciencedirect.com
October 27, 2025 at 7:21 PM
Reposted by Dan Johnson
jmccplus.bsky.social
New work from Nicole S. York and the group of Leigh Anne Swayne at the University of Victoria charts how #H9c2 heart cells change shape, signal, & express genes during differentiation—revealing both their promise & limits as #cardiomyocyte models.

#CardioSky

sciencedirect.com/science/arti...
Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation
Cell culture models enable advancement in our understanding of heart development and heart disease. The H9c2 rat ventricular cardiomyoblast cell line …
sciencedirect.com
October 23, 2025 at 2:18 PM
Reposted by Dan Johnson
jmccplus.bsky.social
Ever wondered how #Calcium channels cluster in #iPSC derived #Cardiomyocytes?

New work just published from Schwenzer et al. should put your mind at rest as they investigated just that!

Check out the latest paper for more information

www.sciencedirect.com/science/arti...

#CardioSky
Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy
The clustering of L-type calcium channels for functional regulation of intracellular calcium signaling remains poorly understood. Here we applied supe…
sciencedirect.com
October 17, 2025 at 10:09 AM
danmjohnson.bsky.social
“Together, we innovate.” 🧬

@escardio.bsky.social is funding collaboration across borders

If you’re an #ECR in #cellular #cardiac #electrophysiology, this is your chance to build connections & push your science forward.

escardio.org/Research/Res...

Deadline- 8 Dec 2025

#CardioSky #BasicScience
Scientific Exchange Grants
Your access to the latest cardiovascular news, science, tools and resources.
escardio.org
October 8, 2025 at 11:45 AM
Reposted by Dan Johnson
jmccplus.bsky.social
Looking for some weekend reading? 📜

New work from from the University of Ottawa Heart Institute, show how metabolic substrates regulate effects of Wnt/β-catenin signaling in #cardiomyocytes, specifically affecting regulation of #Connexin43

sciencedirect.com/science/arti...
Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner
Both Nav1.5 and Cx43 are critical for the fast electrical impulse conduction in the myocardium and their reductions create the arrhythmogenic substrat…
sciencedirect.com
October 3, 2025 at 12:35 PM
Reposted by Dan Johnson
jmccplus.bsky.social
New paper out in our September issue from
Bass-Stringer and colleagues @bakerresearchau.bsky.social
looking at PI3K.

Exploring a new #genetherapy to improve heart function in mice and sheep.

sciencedirect.com/science/arti...

#CardioSky
Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart
Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only availab…
sciencedirect.com
August 7, 2025 at 5:19 PM
danmjohnson.bsky.social
Less than 24 hours to go before the #EWGCCE meeting kicks off @escardio.bsky.social #HeartHouse in the South of France! Looking forward to a great scientific programme and meeting up with colleagues and friends over the next days! Safe travels all!

#CardioSky
June 29, 2025 at 5:11 PM
danmjohnson.bsky.social
Really nice work just out in @jmccplus.bsky.social !
Congrats to the Authors

#CardioSky
May 30, 2025 at 12:15 PM
danmjohnson.bsky.social
Title deadline of 2nd June for @escardio.bsky.social
WG in #Cardiac Cellular #Electrophysiology meeting next month.

Want to hear about the latest work in cellular cardiac electrophysiology-, you know what you need to do!

#cardiosky

esc365.escardio.org/event/1815
49th EWGCCE Meeting 2025 on ESC 365
Seminar on Cellular Electrophysiology by the WG on Cardiac Cellular Electrophysiology to improve your practice and prepare for your exams.
esc365.escardio.org
May 28, 2025 at 3:49 PM
danmjohnson.bsky.social
Upcoming Abstract Deadline!

Interested in attending the Cardiac Cellular Cross Talk meeting in Birmingham in September?

Submit your abstract before the 2nd June! Its going to be a good one!

physoc.org/events/cross...

#CardioSky
Cross-Talk of Cells in the Heart 2025: Novel Mechanisms of Disease and Arrhythmias
Cross-Talk of Cells in the Heart 2025, an exciting two-day meeting at University of Birmingham (UK) to discuss the latest breakthroughs in cardiac arrhythmia and disease research. Join us
physoc.org
May 20, 2025 at 1:10 PM
Reposted by Dan Johnson
ilesla.bsky.social
Considering a return to study in the life/environmental sciences at Masters/PhD level after time away? Working and wondering if full/part-time study is the next step for your career? Our RePOWER workshop on 13th June in Oxford/online will provide advice and support. iles.web.ox.ac.uk/repower-retu...
RePOWER: Returning to Postgraduate Study in the Life and Environmental Sciences
iles.web.ox.ac.uk
May 19, 2025 at 1:55 PM
danmjohnson.bsky.social
Interested in presenting your latest #CardiacElectrophysiology data but didnt have chance to submit an abstract to this years #EWGCCE?

Still time to submit a title and register for this meeting happening in June/July
esc365.escardio.org/event/1815

Hopefully see you there!

#CardioSky
49th EWGCCE Meeting 2025 on ESC 365
Seminar on Cellular Electrophysiology by the WG on Cardiac Cellular Electrophysiology to improve your practice and prepare for your exams.
esc365.escardio.org
May 19, 2025 at 12:53 PM
danmjohnson.bsky.social
Some really nice work just out in @jmccplus.bsky.social
Congrats to the Authors!

#CardioSky
May 9, 2025 at 2:23 PM
danmjohnson.bsky.social
Really nice work just out... Interested in neuro-cardio interactions, have a read!
March 21, 2025 at 12:05 PM
danmjohnson.bsky.social
Deadline Extended until the 10th March for submission of abstracts for the WGCCE meeting this year happening in the south of France!

Submit your abstract today at
esc365.escardio.org/event/1815

This meeting is the perfect place to conduct some great conversations!!

#CardioSky
49th EWGCCE Meeting 2025 on ESC 365
Seminar on Cellular Electrophysiology by the WG on Cardiac Cellular Electrophysiology to improve your practice and prepare for your exams.
esc365.escardio.org
March 5, 2025 at 8:48 PM
danmjohnson.bsky.social
This should be a very interesting webinar! Looking forward to seeing you there!

#CardioSky
jmccplus.bsky.social JMCC Plus @jmccplus.bsky.social · Feb 12
Exciting news! Join us for another exclusive ISHR-ES webinar: The Beating Edge of Cardiac Metabolism! 🫀💡
📅 Friday, 7th March 2025 | ⏰ 14:00 to15:00 GMT + 1| 💻 Live Online

Hear from three leading experts as they dive into cutting-edge research & innovations.
🔗 Register now: https://buff.ly/4aWIbv1
February 12, 2025 at 4:18 PM
danmjohnson.bsky.social
Fantastic news from @jmccplus.bsky.social 🥳🥳

Congrats to all involved..

Im currently hosting a #SpecialIssue on #Remodelling in #HFpEF! 🫀

Feel free to get in touch if you are interested in submitting!
jmccplus.bsky.social JMCC Plus @jmccplus.bsky.social · Jan 30
We are delighted to share that JMCC Plus is now officially indexed in PubMed Central (PMC)! Well done to all the editorial team, particularly our EiC @davorpavlovic.bsky.social and deputy @gundrylab.bsky.social 🎉
buff.ly
January 30, 2025 at 5:59 PM
danmjohnson.bsky.social
Really nice research just out in @jmccplus.bsky.social looking at a novel biomarker for #CardiogenicShock!
Congrats to the Authors!
jmccplus.bsky.social JMCC Plus @jmccplus.bsky.social · Jan 20
Can we predict survival after #CardiogenicShock?

New research from researchers at Helsinki University and the Luxembourg Institute of Health show that a particular miRNA (miR-20b-5p) is associated with survival in cardiogenic shock!

#CardioSky
Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock
Cardiogenic shock (CS) is a medical emergency with high in-hospital mortality. New biomarkers are needed to identify patients at a greater risk of adv…
sciencedirect.com
January 20, 2025 at 7:04 PM
danmjohnson.bsky.social
Fantastic to be at the emeritus celebration of Karin Sipido in Leuven today! Great to see some old friends and colleagues! #CardioSky
January 10, 2025 at 2:23 PM
danmjohnson.bsky.social
A new paper just out in PLoS One looking at how a #HighFatDiet can influence #Cardiac #Electrophysiology and the role of NOX2. Congrats to the Authors and thanks to the Reviewers!

#CardioSky

journals.plos.org/plosone/arti...
January 3, 2025 at 1:50 PM
danmjohnson.bsky.social
Fantastic new work just out in @jmccplus.bsky.social ! Congrats to the Authors, and thanks to the Reviewers

#CardioSky #MedSky
jmccplus.bsky.social JMCC Plus @jmccplus.bsky.social · Dec 18
In our December issue, fantastic research by Jiang et al. highlights how perivascular #fibrosis in intramyocardial blood vessels may play a key role in #myocardialinfarction (#MI) progression.

Read more here: www.sciencedirect.com/science/arti...
December 18, 2024 at 3:08 PM
danmjohnson.bsky.social
Welcome @escardio.bsky.social !
escardio.bsky.social European Society of Cardiology @escardio.bsky.social · Dec 12
Hello #Medsky #CardioSky

The ESC is now on Bluesky🙂

We aim to bring you here the latest in cutting-edge cardiovascular science, from all ESC resources, including the successful #ESCTVToday CV news programme. We equally aim to bring you updates from all ESC communities and to bring you altogether.
December 12, 2024 at 2:18 PM