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cravedilab.bsky.social
Cravedi Lab
@cravedilab.bsky.social
150 followers 180 following 340 posts
Kidney & Immunology Research at Icahn School of Medicine at Mount Sinai
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cravedilab.bsky.social
www.science.org/content/arti...
Can AI capture the mind-boggling complexity of a human cell?
Researchers are competing to make “virtual cells” that could transform biomedicine by predicting gene activity and more
www.science.org
November 29, 2025 at 12:39 AM
cravedilab.bsky.social
www.science.org/content/arti...
With winged legs, orchid mantis sets gliding record
Camouflaged like a flower, these predators also have a getaway trick
www.science.org
November 29, 2025 at 12:37 AM
cravedilab.bsky.social
Kidney transplantation across ABO-H incompatibility in a recipient with Bombay blood group: A novel report - American Journal of Transplantation www.amjtransplant.org/article/S160...
Kidney transplantation across ABO-H incompatibility in a recipient with Bombay blood group: A novel report
The Bombay blood group is an exceptionally rare phenotype characterized by the absence of H antigen on red blood cells due to mutations in the FUT1 gene and absence of H substance in secretions from c...
www.amjtransplant.org
November 26, 2025 at 9:14 PM
cravedilab.bsky.social
Increased Treg in Kidney Transplant Recipients With Erythrocytosis
www.frontierspartnerships.org/journals/tra...
Frontiers Publishing Partnerships | Increased Treg in Kidney Transplant Recipients With Erythrocytosis
Dear Editors, Erythropoietin (EPO) is a glycoprotein hormone produced predominantly by the kidney in response to hypoxia. While widely known for its hematopo...
www.frontierspartnerships.org
November 25, 2025 at 11:07 AM
cravedilab.bsky.social
JCI - Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9 www.jci.org/articles/vie...
JCI - Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9
www.jci.org
November 24, 2025 at 2:48 PM
cravedilab.bsky.social
The Gut–Kidney Axis and Effect on GFR
journals.lww.com/jasn/citatio...
journals.lww.com
November 22, 2025 at 10:51 AM
cravedilab.bsky.social
Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue | EMBO reports
www.embopress.org/doi/full/10....
Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue | EMBO reports
imageimageStressed brown adipocytes release extracellular ATP, which acts as a paracrine signal via P2X4 and P2X7 receptors on macrophages, initiating BAT inflammatory remodeling and degeneration. Blo...
www.embopress.org
November 22, 2025 at 10:50 AM
cravedilab.bsky.social
Macrophage metabolic reprogramming influences adult growth
www.embopress.org/toc/14693178...
EMBO reports: Vol 26, No 22
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
November 22, 2025 at 10:48 AM
cravedilab.bsky.social
From progression to remission: a new paradigm for success in chronic kidney disease - Kidney International www.kidney-international.org/article/S008...
From progression to remission: a new paradigm for success in chronic kidney disease
Recent advances in treatment of chronic kidney disease have changed the clinical paradigm from slowing inevitable progression to achievable remission. Landmark trials involving sodium-glucose cotransp...
www.kidney-international.org
November 18, 2025 at 4:17 PM
cravedilab.bsky.social
An islet-resident macrophage antioxidant program preserves β cell physiology | Science Immunology www.science.org/doi/10.1126/...
An islet-resident macrophage antioxidant program preserves β cell physiology
SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis.
www.science.org
November 18, 2025 at 4:17 PM
cravedilab.bsky.social
A Comprehensive comparative assessment of mean Fluorescence Intensity of Luminex single Antigen bead tests between laboratories and commercial platforms @umaggiore.bsky.social
www.sciencedirect.com/science/arti...
A Comprehensive comparative assessment of mean Fluorescence Intensity of Luminex single Antigen bead tests between laboratories and commercial platforms: A report from the Italian Histocompatibility N...
Reliable and reproducible testing of Donor Specific HLA-Antibodies (DSA) is essential for clinical decisions in organ transplantation. In this prospec…
www.sciencedirect.com
November 17, 2025 at 9:30 PM
Reposted by Cravedi Lab
science.org
An early Triassic bone bed excavated at 78°N changes the story about how marine life recovered after the most cataclysmic extinction in Earth history ~252 million years ago.

Learn more in this week's issue of Science: https://scim.ag/48bLsGI
An early Triassic bone bed excavated at 78°N changes the story about how marine life recovered after the most cataclysmic extinction in Earth history ~252 million years ago. The quantity and diversity of marine reptile and amphibian fossils show that these groups had already radiated into complex oceanic ecosystems by ~249 million years ago.
November 13, 2025 at 7:05 PM
Reposted by Cravedi Lab
lifesciencenet.bsky.social
New method could improve manufacturing of gene-therapy drugs.

#science #news

www.lifescience.net/news/6673/ne...
New method could improve manufacturing of gene-therapy drugs
Selective crystallization can greatly improve the purity, selectivity, and active yield of viral vector-based gene therapy drugs, study finds.
www.lifescience.net
November 7, 2025 at 9:12 PM
cravedilab.bsky.social
Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes url: jamanetwork.com/journals/jam...
Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes
This meta-analysis evaluates the prevalence and characteristics of discordance between creatinine- and cystatin C–based estimated glomerular filtration rate as well as the association of discordance w...
jamanetwork.com
November 7, 2025 at 9:06 PM
cravedilab.bsky.social
JCI - GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity www.jci.org/articles/vie...
JCI - GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity
www.jci.org
November 5, 2025 at 7:56 PM
cravedilab.bsky.social
Drug repurposing in PIK3CA-related overgrowth spectrum: breakthroughs from overgrowth syndromes to kidney disease - Kidney International www.kidney-international.org/article/S008...
Drug repurposing in PIK3CA-related overgrowth spectrum: breakthroughs from overgrowth syndromes to kidney disease
PI3Kα is a ubiquitous lipid kinase that transduces extracellular growth, proliferation and metabolism signals. Genes involved in the PI3Kα signaling pathway are frequently mutated in cancer. Apart fro...
www.kidney-international.org
November 2, 2025 at 5:42 PM
Reposted by Cravedi Lab
genetickidneydoc.bsky.social
Exciting expansion!!
#FSGS #APOL1
October 3, 2025 at 1:35 PM
cravedilab.bsky.social
Subzero Kidney Preservation Comes to Scale - American Journal of Transplantation www.amjtransplant.org/article/S160...
Subzero Kidney Preservation Comes to Scale
Since the 1980s, static cold storage (SCS), and its close cousin hypothermic perfusion, have been the standard preservation methods for kidney grafts. Nevertheless, hypothermic temperatures (4 to 0°C)...
www.amjtransplant.org
October 31, 2025 at 1:19 PM
cravedilab.bsky.social
Epigenetic regulation of T cell exhaustion in cancer

www.nature.com/articles/s41...
Epigenetic regulation of T cell exhaustion in cancer - Nature Reviews Cancer
Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that i...
www.nature.com
October 30, 2025 at 9:06 PM
cravedilab.bsky.social
Biomarkers in CKD:What Does the Future Hold?

journals.lww.com/jasn/citatio...
journals.lww.com
October 30, 2025 at 1:58 AM
cravedilab.bsky.social
Daratumumab Efficacy in Steroid-Resistant Nephrotic Syndrome Correlates with CD38+ B-Cell Depletion

www.kireports.org/article/S246...
Daratumumab Efficacy in Steroid-Resistant Nephrotic Syndrome Correlates with CD38+ B-Cell Depletion
The anti-CD38 monoclonal antibody daratumumab, alone or with anti-CD20 rituximab, can induce remission in steroid-resistant nephrotic syndrome or multidrug-dependent nephrotic syndrome.1 However, the ...
www.kireports.org
October 27, 2025 at 10:52 PM
cravedilab.bsky.social
Mucin O-glycosylation and B cell homing: a new bridge for the gut-kidney axis in IgA nephropathy?
www.kidney-international.org/article/S008...
Mucin O-glycosylation and B cell homing: a new bridge for the gut-kidney axis in IgA nephropathy?
IgA nephropathy (IgAN) is an insidious autoimmune glomerulonephritis that often progresses to end-stage kidney failure, despite anti-inflammatory and anti-proteinuric therapies1. An evolving understan...
www.kidney-international.org
October 26, 2025 at 5:45 PM
cravedilab.bsky.social
Iohexol clearance, but not estimated GFR, reveals a steeper GFR decline in patients with prediabetes
www.kidney-international.org/article/S008...
Iohexol clearance, but not estimated GFR, reveals a steeper GFR decline in patients with prediabetes
Prediabetes, an intermediate state between normoglycemia and type 2 diabetes affecting 720 million individuals worldwide, is associated with hyperfiltration, an early stage of diabetic kidney disease....
www.kidney-international.org
October 26, 2025 at 5:44 PM
cravedilab.bsky.social
Proinflammatory and cytotoxic CD38+HLA-DR+ effector memory CD8+ T cells are peripherally expanded in human cardiac allograft vasculopathy
www.amjtransplant.org/article/S160...
Proinflammatory and cytotoxic CD38+HLA-DR+ effector memory CD8+ T cells are peripherally expanded in human cardiac allograft vasculopathy
Interferon-γ (IFNG) is thought to play a central role in the pathogenesis of cardiac allograft vasculopathy (CAV) in heart transplant (HTx) patients. However, peripheral lymphocytes participating in t...
www.amjtransplant.org
October 26, 2025 at 5:40 PM
cravedilab.bsky.social
Educational Strategies to Prepare Trainees for Clinical Uncertainty | New England Journal of Medicine www.nejm.org/doi/full/10....
Educational Strategies to Prepare Trainees for Clinical Uncertainty | NEJM
Uncertainty is ubiquitous in the practice of medicine. This review characterizes clinical uncertainty and shows how teachers can guide learners to recognize, manage, and communicate uncertainty in ...
www.nejm.org
October 26, 2025 at 5:39 PM