Celia Rouault
@celiarouault.bsky.social
Postdoc at Vindigni lab
Washington University, Saint-Louis, MO
Previous: PhD at Ginestier/Charafe lab, CRCM, France
Washington University, Saint-Louis, MO
Previous: PhD at Ginestier/Charafe lab, CRCM, France
Pinned
I am thrilled to share my first paper published in @naturecomms.bsky.social, Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARPi in breast cancer @Christophe Ginestier @emmanuellecharafe.bsky.social I thanks all the collaborators and supporters
rdcu.be/ecaao
rdcu.be/ecaao
Reposted by Celia Rouault
🕵️♀️ In this cancer Clue game:
🧬 Victim: CSCs
🔪 Weapon: Nifuroxazide
🎯 Mode: DNA crosslinks + STAT3 block
🧬 Scene: PARPi-resistant breast cancer
From the Charafe/Ginestier team @CRCM
🔗 pubmed.ncbi.nlm.nih.gov/40038300/
✍️ by @celiarouault.bsky.social
🔗 communities.springernature.com/posts/unveil...
🧬 Victim: CSCs
🔪 Weapon: Nifuroxazide
🎯 Mode: DNA crosslinks + STAT3 block
🧬 Scene: PARPi-resistant breast cancer
From the Charafe/Ginestier team @CRCM
🔗 pubmed.ncbi.nlm.nih.gov/40038300/
✍️ by @celiarouault.bsky.social
🔗 communities.springernature.com/posts/unveil...
April 24, 2025 at 8:13 AM
🕵️♀️ In this cancer Clue game:
🧬 Victim: CSCs
🔪 Weapon: Nifuroxazide
🎯 Mode: DNA crosslinks + STAT3 block
🧬 Scene: PARPi-resistant breast cancer
From the Charafe/Ginestier team @CRCM
🔗 pubmed.ncbi.nlm.nih.gov/40038300/
✍️ by @celiarouault.bsky.social
🔗 communities.springernature.com/posts/unveil...
🧬 Victim: CSCs
🔪 Weapon: Nifuroxazide
🎯 Mode: DNA crosslinks + STAT3 block
🧬 Scene: PARPi-resistant breast cancer
From the Charafe/Ginestier team @CRCM
🔗 pubmed.ncbi.nlm.nih.gov/40038300/
✍️ by @celiarouault.bsky.social
🔗 communities.springernature.com/posts/unveil...
Sometimes, conducting research feels like a police investigation!
Discover the parallel between our article: Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer and police enquiry communities.springernature.com/posts/unveil... @cginestier.bsky.social
Discover the parallel between our article: Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer and police enquiry communities.springernature.com/posts/unveil... @cginestier.bsky.social
Unveiling the Criminal Masterminds: Innovative Strategies in Cancer Research
communities.springernature.com
April 4, 2025 at 12:00 PM
Sometimes, conducting research feels like a police investigation!
Discover the parallel between our article: Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer and police enquiry communities.springernature.com/posts/unveil... @cginestier.bsky.social
Discover the parallel between our article: Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer and police enquiry communities.springernature.com/posts/unveil... @cginestier.bsky.social
Reposted by Celia Rouault
Cells control the supply of new histones to chromatin by blocking histone chaperone function - see here how Codanin-1 sequesters 4 ASF1 molecules.
𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇
CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply
Nature Communications - CODANIN-1 negatively regulates the function of ASF1, the key chaperone for histone H3-H4 supply. Here the authors present the cryo-EM structure of the CODANIN-1_ASF1A...
rdcu.be
March 23, 2025 at 12:04 PM
Cells control the supply of new histones to chromatin by blocking histone chaperone function - see here how Codanin-1 sequesters 4 ASF1 molecules.
Reposted by Celia Rouault
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
March 17, 2025 at 9:58 PM
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
Reposted by Celia Rouault
Glad to have contributed to this beautiful work led by @celiarouault.bsky.social & colleagues at @crcm.bsky.social just out in @naturecomms.bsky.social. Using drug repurposing, they unveiled the STAT3/FanA axis as a targetable vulnerability in breast cancer stem cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer - Nature Communications
Targeting cancer stem cells (CSCs) has great potential in anti-cancer treatment. Here this group reports the role of antibiotic Nifuroxazide as a potent anti-CSC compound and fabricates it into an ant...
www.nature.com
March 4, 2025 at 12:12 PM
Glad to have contributed to this beautiful work led by @celiarouault.bsky.social & colleagues at @crcm.bsky.social just out in @naturecomms.bsky.social. Using drug repurposing, they unveiled the STAT3/FanA axis as a targetable vulnerability in breast cancer stem cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I am thrilled to share my first paper published in @naturecomms.bsky.social, Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARPi in breast cancer @Christophe Ginestier @emmanuellecharafe.bsky.social I thanks all the collaborators and supporters
rdcu.be/ecaao
rdcu.be/ecaao
March 4, 2025 at 1:28 PM
I am thrilled to share my first paper published in @naturecomms.bsky.social, Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARPi in breast cancer @Christophe Ginestier @emmanuellecharafe.bsky.social I thanks all the collaborators and supporters
rdcu.be/ecaao
rdcu.be/ecaao
Reposted by Celia Rouault
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability
Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.
tinyurl.com
February 19, 2025 at 7:35 PM
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Reposted by Celia Rouault
Check out our (@vindignilab.bsky.social) Spotlight article highlighting @durocher1.bsky.social group's discovery of synthetic lethal SMARCAL1-FANCM interaction, revealing a novel genetic buffering mechanism for genome stability at simple repeat regions during replication
www.cell.com/trends/genet...
www.cell.com/trends/genet...
Genetic buffering mechanisms in SNF2-family translocases
SNF2-family DNA translocases, a large family of ATPases, have poorly defined roles
in genomic stability. In a recent study, Feng et al. identified a synthetic lethal
interaction between the SNF2 trans...
www.cell.com
January 31, 2025 at 10:12 PM
Check out our (@vindignilab.bsky.social) Spotlight article highlighting @durocher1.bsky.social group's discovery of synthetic lethal SMARCAL1-FANCM interaction, revealing a novel genetic buffering mechanism for genome stability at simple repeat regions during replication
www.cell.com/trends/genet...
www.cell.com/trends/genet...