@carstenskarke.bsky.social
Translational Scientist, Biorhythms, Science Educator, SciArt
Reposted
How is #BrainDevelopment linked to the emergence of #MentalHealthDisorders? Harmonizing & sharing #Neuroimaging data & well-defined psychiatric phenotypes are essential building blocks to pursue answers: doi.org/10.1016/j.ne... @sattertt @pennlinc.bsky.social #TranslationalScience
Redirecting
doi.org
September 25, 2025 at 5:17 PM
How is #BrainDevelopment linked to the emergence of #MentalHealthDisorders? Harmonizing & sharing #Neuroimaging data & well-defined psychiatric phenotypes are essential building blocks to pursue answers: doi.org/10.1016/j.ne... @sattertt @pennlinc.bsky.social #TranslationalScience
Reposted
Refining first-in-human dual-targeting chimeric antigen receptor (CAR)-T cells for #Glioblastoma with real-time #Organoid modeling. doi.org/10.1016/j.st... #Cancer #CARTcelltherapy #TranslationalScience
January 28, 2025 at 6:12 PM
Refining first-in-human dual-targeting chimeric antigen receptor (CAR)-T cells for #Glioblastoma with real-time #Organoid modeling. doi.org/10.1016/j.st... #Cancer #CARTcelltherapy #TranslationalScience
Reposted
Speech & Age: Vocal fold tissue remodeled from infancy to maturity. Key proteins influence biomechanics, paving the way for new treatment approaches for voice disorders. doi.org/10.1080/0300...
@RicGottardi
@Bio2GottardiLab
#TranslationalScience
@RicGottardi
@Bio2GottardiLab
#TranslationalScience
Age-related remodeling of the vocal fold extracellular matrix composition, structure, and biomechanics during tissue maturation
The vocal folds (VFs) are among the most mechanically active connective tissues, vibrating between 80 and 250 hz during speech. Overall VF function is determined by the composition and structure of...
doi.org
January 30, 2025 at 6:57 PM
Speech & Age: Vocal fold tissue remodeled from infancy to maturity. Key proteins influence biomechanics, paving the way for new treatment approaches for voice disorders. doi.org/10.1080/0300...
@RicGottardi
@Bio2GottardiLab
#TranslationalScience
@RicGottardi
@Bio2GottardiLab
#TranslationalScience
Reposted
Common nanoparticle linkers may hijack the #ImmuneSystem, drive toxicity and misdirect #DrugDelivery. However, @jakebrenner lab uncovers molecular mechanisms & develops solutions to mitigate these effects doi.org/10.1002/adma... #Nanomedicine #TranslationalScience
February 4, 2025 at 8:18 PM
Common nanoparticle linkers may hijack the #ImmuneSystem, drive toxicity and misdirect #DrugDelivery. However, @jakebrenner lab uncovers molecular mechanisms & develops solutions to mitigate these effects doi.org/10.1002/adma... #Nanomedicine #TranslationalScience
Reposted
Personalizing therapeutic modalities for #Glioblastoma through modelling routine care data, led by @chrisdav66. Check out doi.org/10.1093/neuo... @glioblastf @glioblastomaorg #NeuroImaging #TranslationalScience
Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study
AbstractBackground. Glioblastoma (GBM) is the most aggressive adult primary brain cancer, characterized by significant heterogeneity, posing challenges for
doi.org
February 11, 2025 at 4:51 PM
Personalizing therapeutic modalities for #Glioblastoma through modelling routine care data, led by @chrisdav66. Check out doi.org/10.1093/neuo... @glioblastf @glioblastomaorg #NeuroImaging #TranslationalScience
Reposted
Extending the #OrganOnAChip technology to mimic #BoneMarrow enabling mechanistic studies on injury models, #DrugToxicity, and more. Check out doi.org/10.1016/j.st... @PennEngineers #PennEngineering #TranslationalScience
February 13, 2025 at 5:51 PM
Extending the #OrganOnAChip technology to mimic #BoneMarrow enabling mechanistic studies on injury models, #DrugToxicity, and more. Check out doi.org/10.1016/j.st... @PennEngineers #PennEngineering #TranslationalScience
Reposted
Shift in understanding: Progenitor capacity of pulmonary venous endothelial cells drives #LungInjury repair doi.org/10.1038/s441... #PulmonaryFunction #LungHealth
@vaughandy.bsky.social
#TranslationalScience
@vaughandy.bsky.social
#TranslationalScience
Dynamic behavior and lineage plasticity of the pulmonary venous endothelium - Nature Cardiovascular Research
Wong et al. identify Slc6a2 as a marker of pulmonary venous endothelial cells and demonstrate that these cells differentiate into capillary endothelial cells during vascular regeneration after lung in...
doi.org
February 18, 2025 at 8:19 PM
Shift in understanding: Progenitor capacity of pulmonary venous endothelial cells drives #LungInjury repair doi.org/10.1038/s441... #PulmonaryFunction #LungHealth
@vaughandy.bsky.social
#TranslationalScience
@vaughandy.bsky.social
#TranslationalScience
Reposted
Nervous when the next #Seizure in seizure-prone #Neonates will strike? Predictive modeling finetunes necessary #cEEG duration to identify electroencephalographic seizures for various risk profiles: onlinelibrary.wiley.com/doi/10.1111/... #NICU #TranslationalScience
Development of a model to predict electroencephalographic seizures in neonates with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
Objective Electroencephalographic seizures (ES) are common in neonates with hypoxic–ischemic encephalopathy (HIE), but identification with continuous electroencephalographic (EEG) monitoring (CEEG) ...
onlinelibrary.wiley.com
February 20, 2025 at 8:22 PM
Nervous when the next #Seizure in seizure-prone #Neonates will strike? Predictive modeling finetunes necessary #cEEG duration to identify electroencephalographic seizures for various risk profiles: onlinelibrary.wiley.com/doi/10.1111/... #NICU #TranslationalScience
Reposted
Promising leads in therapeutic advances for metabolic dysfunction-associated steatotic #LiverDisease (#MASLD) doi.org/10.1016/j.cm... @WellenLab
February 25, 2025 at 8:57 PM
Promising leads in therapeutic advances for metabolic dysfunction-associated steatotic #LiverDisease (#MASLD) doi.org/10.1016/j.cm... @WellenLab
Reposted
Advancing our understanding of immunogenic epitope selection, with implications for #VaccineDevelopment and T cell–based therapies. doi.org/10.1073/pnas... #CryoEM @moiseenkovabell #TranslationalScience
February 27, 2025 at 7:16 PM
Advancing our understanding of immunogenic epitope selection, with implications for #VaccineDevelopment and T cell–based therapies. doi.org/10.1073/pnas... #CryoEM @moiseenkovabell #TranslationalScience
Reposted
Check this out! Monitoring the spatiotemporal dynamics of #mRNAvaccine antigen expression in vivo www.nature.com/articles/s41... @drewweissmanlab.bsky.social #TranslationalScience
March 6, 2025 at 10:07 PM
Check this out! Monitoring the spatiotemporal dynamics of #mRNAvaccine antigen expression in vivo www.nature.com/articles/s41... @drewweissmanlab.bsky.social #TranslationalScience
Reposted
Rewiring exhausted T cells to create therapeutic innovations for #ChronicInfections & #CancerTreatment doi.org/10.1126/scii... @ejohnwherry.bsky.social #ImmuneHealth #TranslationalScience
Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.
doi.org
March 11, 2025 at 7:08 PM
Rewiring exhausted T cells to create therapeutic innovations for #ChronicInfections & #CancerTreatment doi.org/10.1126/scii... @ejohnwherry.bsky.social #ImmuneHealth #TranslationalScience
Reposted
Early nonresponse to behavioral obesity treatment doesn’t have to mean failure. Adding anti-obesity medication doubles weight loss. doi.org/10.1038/s415... #ObesityResearch #WeightLossScience #TranslationalScience
March 13, 2025 at 10:22 PM
Early nonresponse to behavioral obesity treatment doesn’t have to mean failure. Adding anti-obesity medication doubles weight loss. doi.org/10.1038/s415... #ObesityResearch #WeightLossScience #TranslationalScience
Reposted
#CRISPR/Cas9 gene editing establishes preclinical platform to evaluate #IsletTransplantation & #DrugDiscovery approaches doi.org/10.2337/db23... @kkaestner.bsky.social #DiabetesResearch #IsletBiology #TranslationalScience
The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets
The gold standard for assessing the function of human islets or β-like cells derived from stem cells involves their engraftment under the kidney capsule of
doi.org
March 18, 2025 at 5:41 PM
#CRISPR/Cas9 gene editing establishes preclinical platform to evaluate #IsletTransplantation & #DrugDiscovery approaches doi.org/10.2337/db23... @kkaestner.bsky.social #DiabetesResearch #IsletBiology #TranslationalScience
Reposted
Key metabolic enzyme tied to alcohol consumption discovered with #DrugDevelopment opportunities but maybe only for males doi.org/10.1016/j.ne... @berger_lab #AddictionResearch #AlcoholUseDisorder #TranslationalScience
Redirecting
doi.org
March 20, 2025 at 5:46 PM
Key metabolic enzyme tied to alcohol consumption discovered with #DrugDevelopment opportunities but maybe only for males doi.org/10.1016/j.ne... @berger_lab #AddictionResearch #AlcoholUseDisorder #TranslationalScience
Reposted
Novel non-anticoagulant therapeutics to curb the immune response in Heparin-Induced #Thrombocytopenia #HIT doi.org/10.1182/bloo... #DrugDevelopment #TranslationalScience
March 27, 2025 at 8:13 PM
Novel non-anticoagulant therapeutics to curb the immune response in Heparin-Induced #Thrombocytopenia #HIT doi.org/10.1182/bloo... #DrugDevelopment #TranslationalScience
Reposted
Comprehensive study linking #Aging, #Diet, #Health and #HostGenetics in the #Microbiome doi.org/10.1038/s415... @ChristophThaiss @ThaissLab #TranslationalScience
Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice - Nature Microbiology
Using a cohort of nearly 1,000 genetically diverse mice undergoing dietary restriction over the lifespan, the authors reveal numerous insights into the interactions between the gut microbiome, host ge...
doi.org
April 1, 2025 at 6:40 PM
Comprehensive study linking #Aging, #Diet, #Health and #HostGenetics in the #Microbiome doi.org/10.1038/s415... @ChristophThaiss @ThaissLab #TranslationalScience
Reposted
Translating mechanistic insights from #Telomeropathies into therapeutic opportunities doi.org/10.1172/JCI1... @daria-babushok.bsky.social #TelomereBiologyDisorders #RareDiseases #TranslationalScience
JCI -
ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders
doi.org
April 4, 2025 at 4:40 PM
Translating mechanistic insights from #Telomeropathies into therapeutic opportunities doi.org/10.1172/JCI1... @daria-babushok.bsky.social #TelomereBiologyDisorders #RareDiseases #TranslationalScience
Reposted
Characterizing molecular programs guiding #CardioPulmonary maturation through integration of #SpatialTranscriptomics with #Computational #CellTrajectory analysis and #TranscriptionalProfiling doi.org/10.1016/j.ce... #CellAtlas #TranslationalScience
April 8, 2025 at 6:59 PM
Characterizing molecular programs guiding #CardioPulmonary maturation through integration of #SpatialTranscriptomics with #Computational #CellTrajectory analysis and #TranscriptionalProfiling doi.org/10.1016/j.ce... #CellAtlas #TranslationalScience
Reposted
105 new loci at #genome-wide significance linked to 5 distinct traits/diseases with shared #GeneticSusceptibility to #HeartFailure doi.org/10.1038/s415... @DavidSMLee @bvoight28.bsky.social @MarylynRitchie @damrauer #TranslationalScience
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum - Nature Genetics
Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across the allele-frequency sp...
doi.org
April 11, 2025 at 12:45 PM
105 new loci at #genome-wide significance linked to 5 distinct traits/diseases with shared #GeneticSusceptibility to #HeartFailure doi.org/10.1038/s415... @DavidSMLee @bvoight28.bsky.social @MarylynRitchie @damrauer #TranslationalScience
Reposted
Profound shifts in tumor and immune cell subpopulations after high-risk #Neuroblastoma therapy with signaling in HB-EGF–ERBB4 axis between macrophage and neoplastic subsets doi.org/10.1038/s415... #SingleCell #TranslationalScience
Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring - Nature Genetics
Analysis of pre- and post-chemotherapy samples collected from 22 patients with high-risk neuroblastoma using single-nucleus RNA and ATAC sequencing and spatial omics characterizes therapy-related chan...
doi.org
April 15, 2025 at 12:45 PM
Profound shifts in tumor and immune cell subpopulations after high-risk #Neuroblastoma therapy with signaling in HB-EGF–ERBB4 axis between macrophage and neoplastic subsets doi.org/10.1038/s415... #SingleCell #TranslationalScience
Reposted
Mapping the brain’s complexity of genetic and neuroanatomical heterogeneity simultaneously doi.org/10.1038/s414... #BrainImaging #Genomics #Neuroscience #TranslationalScience
A genetically informed brain atlas for enhancing brain imaging genomics - Nature Communications
GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain im...
doi.org
April 17, 2025 at 2:08 PM
Mapping the brain’s complexity of genetic and neuroanatomical heterogeneity simultaneously doi.org/10.1038/s414... #BrainImaging #Genomics #Neuroscience #TranslationalScience
Reposted
#RedBloodCells (RBCs) display mechanically active role in contraction of #BloodClots: Platelet-depleted clots formed in the presence of RBCs exhibited >20% volume shrinkage 10.1182/bloodadvances.2024015533 #Thrombosis #Hemostasis #TranslationalScience
Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage
Key Points. RBCs suspended in platelet-depleted plasma undergo aggregation within a thrombin-induced clot and cause platelet-independent clot shrinkage.RBC
urldefense.com
April 22, 2025 at 10:36 PM
#RedBloodCells (RBCs) display mechanically active role in contraction of #BloodClots: Platelet-depleted clots formed in the presence of RBCs exhibited >20% volume shrinkage 10.1182/bloodadvances.2024015533 #Thrombosis #Hemostasis #TranslationalScience
Reposted
CHAC1 emerging as #KidneyDisease #RiskGene with a central role of modulating tubule cell glutathione and #Ferroptosis doi.org/10.1126/scit... @ksusztak.bsky.social #DrugDevelopmentOption #TranslationalScience
Glutathione-specific gamma–glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis
CHAC1 is a kidney disease risk gene, and removal of one copy of Chac1 protects mice from kidney disease by controlling glutathione and ferroptosis.
doi.org
April 24, 2025 at 7:09 PM
CHAC1 emerging as #KidneyDisease #RiskGene with a central role of modulating tubule cell glutathione and #Ferroptosis doi.org/10.1126/scit... @ksusztak.bsky.social #DrugDevelopmentOption #TranslationalScience
Reposted
Targeting #Lung #EndothelialCells & #EpithelialCells through #LNPtechnology without off-target editing in the liver offers #DrugDevelopment pubs.acs.org/doi/10.1021/... @MJMitchell_Lab #LipidNanoparticles #Nanomedicine #TranslationalScience
Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets
In the past 10 years, CRISPR-Cas9 has revolutionized the gene-editing field due to its modularity, simplicity, and efficacy. It has been applied for the creation of in vivo models, to further understa...
pubs.acs.org
April 29, 2025 at 7:31 PM
Targeting #Lung #EndothelialCells & #EpithelialCells through #LNPtechnology without off-target editing in the liver offers #DrugDevelopment pubs.acs.org/doi/10.1021/... @MJMitchell_Lab #LipidNanoparticles #Nanomedicine #TranslationalScience