Benjamin Pierce
@benjaminpierce.bsky.social
Retired analyst and presentation specialist. Avid listener, walker, and reader of scientific journals. Interested in advancements in science, data analysis tools to improve healthcare.
Reposted by Benjamin Pierce
🧪 Evo-2, the largest AI model for biology, is here. Trained on 128K genomes, it can generate entire chromosomes and decode noncoding DNA linked to disease. Scientists see it as an "app store" for biology. 🧬💻
Biggest-ever AI biology model writes DNA on demand
An artificial-intelligence network trained on a vast trove of sequence data is a step towards designing completely new genomes.
www.nature.com
February 20, 2025 at 4:54 PM
🧪 Evo-2, the largest AI model for biology, is here. Trained on 128K genomes, it can generate entire chromosomes and decode noncoding DNA linked to disease. Scientists see it as an "app store" for biology. 🧬💻
Reposted by Benjamin Pierce
GENERator: A Long-Context Generative Genomic Foundation Model https://arxiv.org/abs/2502.07272 🧬🖥️🧪 https://huggingface.co/GenerTeam https://github.com/GenerTeam/GENERator
February 12, 2025 at 9:04 PM
GENERator: A Long-Context Generative Genomic Foundation Model https://arxiv.org/abs/2502.07272 🧬🖥️🧪 https://huggingface.co/GenerTeam https://github.com/GenerTeam/GENERator
A Scottish research team collected almost a million eye scans from opticians to use for AI prediction of neurogenerative diseases.
"Something very simple like a photograph of a retina can now be harnessed to potentially predict brain change later on in life."
www.bbc.com/news/article...
"Something very simple like a photograph of a retina can now be harnessed to potentially predict brain change later on in life."
www.bbc.com/news/article...
AI could help diagnose dementia through eye tests
Researchers are working on a new AI tool that could be used by high-street opticians to spot signs of the disease.
www.bbc.com
January 30, 2025 at 5:25 AM
A Scottish research team collected almost a million eye scans from opticians to use for AI prediction of neurogenerative diseases.
"Something very simple like a photograph of a retina can now be harnessed to potentially predict brain change later on in life."
www.bbc.com/news/article...
"Something very simple like a photograph of a retina can now be harnessed to potentially predict brain change later on in life."
www.bbc.com/news/article...
Reposted by Benjamin Pierce
In 2025, health care execs foresee AI-driven diagnostics, personalized medicine, and better care coordination improving outcomes. Yet, regulatory hurdles and validation remain key challenges for adoption. #HealthIT 🩺💻
24 Executive Healthcare AI Predictions & Trends to Watch in 2025
Can AI solve the physician shortage and revolutionize chronic disease management? Healthcare executives share their predictions for 2025
hitconsultant.net
January 16, 2025 at 4:51 PM
In 2025, health care execs foresee AI-driven diagnostics, personalized medicine, and better care coordination improving outcomes. Yet, regulatory hurdles and validation remain key challenges for adoption. #HealthIT 🩺💻
Reposted by Benjamin Pierce
Quanterix to Acquire Akoya Biosciences, Creating the First Integrated Solution for Ultra-Sensitive Detection of Blood- and Tissue-Based Protein Biomarkers www.businesswire.com/news/home/20...
Quanterix to Acquire Akoya Biosciences, Creating the First Integrated Solution for Ultra-Sensitive Detection of Blood- and Tissue-Based Protein Biomarkers
Quanterix Corporation (NASDAQ: QTRX), a company fueling scientific discovery through ultra-sensitive biomarker detection, and Akoya Biosciences (NASDA
www.businesswire.com
January 11, 2025 at 8:09 AM
Quanterix to Acquire Akoya Biosciences, Creating the First Integrated Solution for Ultra-Sensitive Detection of Blood- and Tissue-Based Protein Biomarkers www.businesswire.com/news/home/20...
Reposted by Benjamin Pierce
Great overview for 2024 drug approvals
open.substack.com/pub/thealiqu...
open.substack.com/pub/thealiqu...
Let There Be Drugs 2.0
A Year of Firsts, Breakthroughs & AI Awareness
open.substack.com
January 5, 2025 at 7:47 AM
Great overview for 2024 drug approvals
open.substack.com/pub/thealiqu...
open.substack.com/pub/thealiqu...
Reposted by Benjamin Pierce
What a fantastic way to start the year! The KoiralaLab (unfortunately not here yet) have just developed RNA derived antibodies to visualize RNA in live cells! This seems to be a promising alternative to the MCP-MS2 system whilst offering potential multiplexing capabilities.
#RNA, #RNASky, #imaging
#RNA, #RNASky, #imaging
Synthetic anti-RNA antibody derivatives for RNA visualization in mammalian cells
Abstract. Although antibody derivatives, such as Fabs and scFvs, have revolutionized the cellular imaging, quantification and tracking of proteins, analogo
academic.oup.com
January 1, 2025 at 10:58 AM
President Carter's lesser known accomplishments:
The Carter Center greatly reduced Guinea Worm disease and River Blindness. In 1980, there were 3.5 million Guinea Worm cases. In 2024, only 14 cases. In 1980, over 18 million people were affected by River Blindness, now significantly reduced.
The Carter Center greatly reduced Guinea Worm disease and River Blindness. In 1980, there were 3.5 million Guinea Worm cases. In 2024, only 14 cases. In 1980, over 18 million people were affected by River Blindness, now significantly reduced.
December 30, 2024 at 1:29 AM
President Carter's lesser known accomplishments:
The Carter Center greatly reduced Guinea Worm disease and River Blindness. In 1980, there were 3.5 million Guinea Worm cases. In 2024, only 14 cases. In 1980, over 18 million people were affected by River Blindness, now significantly reduced.
The Carter Center greatly reduced Guinea Worm disease and River Blindness. In 1980, there were 3.5 million Guinea Worm cases. In 2024, only 14 cases. In 1980, over 18 million people were affected by River Blindness, now significantly reduced.
FDA approved 19 AI/ML devices in September. The rate of AI/ML in assisting in heathcare diagnostics is increasing each month.
www.fda.gov/medical-devi...
www.fda.gov/medical-devi...
Artificial Intelligence and Machine Learning (AI/ML)-Enabled Medical D
The FDA has updated the list of AI/ML-enabled medical devices marketed in the United States as a resource to the public.
www.fda.gov
December 30, 2024 at 12:29 AM
FDA approved 19 AI/ML devices in September. The rate of AI/ML in assisting in heathcare diagnostics is increasing each month.
www.fda.gov/medical-devi...
www.fda.gov/medical-devi...
Reposted by Benjamin Pierce
I missed this one last month. New AI tool predicts gene expression from pathology slide images:
Digital profiling of gene expression from histology images with linearized attention https://www.nature.com/articles/s41467-024-54182-5 🧬🖥️🧪 https://github.com/gevaertlab/sequoia-pub
Digital profiling of gene expression from histology images with linearized attention https://www.nature.com/articles/s41467-024-54182-5 🧬🖥️🧪 https://github.com/gevaertlab/sequoia-pub
December 16, 2024 at 9:00 PM
I missed this one last month. New AI tool predicts gene expression from pathology slide images:
Digital profiling of gene expression from histology images with linearized attention https://www.nature.com/articles/s41467-024-54182-5 🧬🖥️🧪 https://github.com/gevaertlab/sequoia-pub
Digital profiling of gene expression from histology images with linearized attention https://www.nature.com/articles/s41467-024-54182-5 🧬🖥️🧪 https://github.com/gevaertlab/sequoia-pub
Reposted by Benjamin Pierce
POEM emerges as a preferred treatment for type III achalasia, emphasizing individualized patient care and careful monitoring post-procedure.
by Yang D, Bechara R, Dunst CM and Konda VJA in Gastroenterology #MedSky
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S001650852405457X
by Yang D, Bechara R, Dunst CM and Konda VJA in Gastroenterology #MedSky
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S001650852405457X
December 10, 2024 at 8:31 PM
POEM emerges as a preferred treatment for type III achalasia, emphasizing individualized patient care and careful monitoring post-procedure.
by Yang D, Bechara R, Dunst CM and Konda VJA in Gastroenterology #MedSky
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S001650852405457X
by Yang D, Bechara R, Dunst CM and Konda VJA in Gastroenterology #MedSky
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S001650852405457X
Reposted by Benjamin Pierce
New method compresses terabytes of genomic data into gigabytes medicalxpress.com/news/2024-12...
December 6, 2024 at 3:03 PM
New method compresses terabytes of genomic data into gigabytes medicalxpress.com/news/2024-12...
AI applications in radiology continues to advance. This week's Radiological Society of North America conference is highlighting that there are more than 300 FDA-approved AI tools for imaging.
www.healthcareitnews.com/news/ai-tran...
www.healthcareitnews.com/news/ai-tran...
AI is transforming imaging, with FDA approvals continuing apace
As RSNA kicks off in Chicago, here's a roundup of some recent radiology and imaging IT announcements.
www.healthcareitnews.com
December 3, 2024 at 2:01 AM
AI applications in radiology continues to advance. This week's Radiological Society of North America conference is highlighting that there are more than 300 FDA-approved AI tools for imaging.
www.healthcareitnews.com/news/ai-tran...
www.healthcareitnews.com/news/ai-tran...
Reposted by Benjamin Pierce
Need long-read sequencing? We just completed the first ever run on @uoregon.bsky.social GC3F core’s new
@pacbio.bsky.social Revio instrument! Perfect for amplicons too long for Illumina, and with Kinnex, you can get >10x more data. Great pricing, no queue, try it: gc3f.uoregon.edu/pacbio-seque...
@pacbio.bsky.social Revio instrument! Perfect for amplicons too long for Illumina, and with Kinnex, you can get >10x more data. Great pricing, no queue, try it: gc3f.uoregon.edu/pacbio-seque...
November 25, 2024 at 2:53 PM
Need long-read sequencing? We just completed the first ever run on @uoregon.bsky.social GC3F core’s new
@pacbio.bsky.social Revio instrument! Perfect for amplicons too long for Illumina, and with Kinnex, you can get >10x more data. Great pricing, no queue, try it: gc3f.uoregon.edu/pacbio-seque...
@pacbio.bsky.social Revio instrument! Perfect for amplicons too long for Illumina, and with Kinnex, you can get >10x more data. Great pricing, no queue, try it: gc3f.uoregon.edu/pacbio-seque...
"Instead of using AI to analyze images, AI can help with the drudgery and let the doctor do what doctors enjoy doing and are really good at, which is reading the scans”. In this example, tedious documentation tasks can be automated.
techcrunch.com/2024/11/20/b...
techcrunch.com/2024/11/20/b...
Benchmark invests $19M in New Lantern, a smarter way for radiologists to use AI | TechCrunch
Shiva Suri gained a unique perspective into how radiologists work when he quarantined and shared a home office with his mom, a well-regarded radiologist.
techcrunch.com
November 25, 2024 at 4:18 AM
"Instead of using AI to analyze images, AI can help with the drudgery and let the doctor do what doctors enjoy doing and are really good at, which is reading the scans”. In this example, tedious documentation tasks can be automated.
techcrunch.com/2024/11/20/b...
techcrunch.com/2024/11/20/b...
We currently don't have a gold standard in medical care. These is the right question, "How close does generative AI bring us to the gold standard?" This needs to be measured.
www.medpagetoday.com/practicemana...
www.medpagetoday.com/practicemana...
New FDA Panel Weighs In on Regulating Generative AI in Healthcare
Committee's 2-day meeting focused on evaluating and monitoring performance and risk
www.medpagetoday.com
November 24, 2024 at 5:35 AM
We currently don't have a gold standard in medical care. These is the right question, "How close does generative AI bring us to the gold standard?" This needs to be measured.
www.medpagetoday.com/practicemana...
www.medpagetoday.com/practicemana...
Reposted by Benjamin Pierce
This is awesome, so clearly written!
I very much appreciate people who are able to lay out the landscape of a field so clearly.
I very much appreciate people who are able to lay out the landscape of a field so clearly.
The first review article from my lab, helmed by @celiasouque.bsky.social, "From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance" is now online and open access at Annual Reviews Microbiology:
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
November 23, 2024 at 11:28 PM
This is awesome, so clearly written!
I very much appreciate people who are able to lay out the landscape of a field so clearly.
I very much appreciate people who are able to lay out the landscape of a field so clearly.
Reposted by Benjamin Pierce
Interesting paper from the Lackner Lab on the connection between mitochondrial dynamics and mtDNA.
doi.org/10.1091/mbc....
doi.org/10.1091/mbc....
Significantly reduced, but balanced, rates of mitochondrial fission and fusion are sufficient to maintain the integrity of yeast mitochondrial DNA | Molecular Biology of the Cell
Mitochondria exist as dynamic tubular networks and the morphology of these networks impacts organelle function and cell health. Mitochondrial morphology is maintained in part by the opposing activitie...
doi.org
November 23, 2024 at 4:12 AM
Interesting paper from the Lackner Lab on the connection between mitochondrial dynamics and mtDNA.
doi.org/10.1091/mbc....
doi.org/10.1091/mbc....
Reposted by Benjamin Pierce
Reposted by Benjamin Pierce
IDH-mutant gliomas evolve from slow-cycling OPC-like cells to proliferative NPC-like cells through chromatin reprogramming and genetic alterations. This transition reveals key mechanisms of tumor progression. www.nature.com/articles/s43...
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas - Nature Cancer
Wu et al. perform single-cell analyses to explore the switch from low-grade to high-grade isocitrate-dehydrogenase-mutant glioma and show that it is characterized by oligodendrocyte progenitor cell-li...
www.nature.com
November 22, 2024 at 3:07 AM
IDH-mutant gliomas evolve from slow-cycling OPC-like cells to proliferative NPC-like cells through chromatin reprogramming and genetic alterations. This transition reveals key mechanisms of tumor progression. www.nature.com/articles/s43...
Reposted by Benjamin Pierce
A nice weekend read.
www.cell.com/cell/fulltex...
Small and long non-coding RNAs: Past, present, and future
#RNA, #RNASky
www.cell.com/cell/fulltex...
Small and long non-coding RNAs: Past, present, and future
#RNA, #RNASky
www.cell.com
November 16, 2024 at 10:54 AM
A nice weekend read.
www.cell.com/cell/fulltex...
Small and long non-coding RNAs: Past, present, and future
#RNA, #RNASky
www.cell.com/cell/fulltex...
Small and long non-coding RNAs: Past, present, and future
#RNA, #RNASky
A Dr. will always need to be in-the-loop for medical treatment. But AI technology can assist and present information for review to medical decision makers.
Properly developed and certified, healthcare assistance workload and errors can be reduced on non-complex issues, while improving outcomes.
Properly developed and certified, healthcare assistance workload and errors can be reduced on non-complex issues, while improving outcomes.
At some point soon we are going to need to start thinking about when AI use should be required as part of the goal of providing the best care. It won’t be good for everything, but it definitely will be for some things.
A lot will need to change about how we view medicine.
A lot will need to change about how we view medicine.
There are now 5 reports like this—#AI performing better than physicians + AI—and we don’t have the explanation for why yet (hybrid was supposed to be best)
Gift link nytimes.com/2024/11/17/hea…
Gift link nytimes.com/2024/11/17/hea…
November 21, 2024 at 1:39 AM
A Dr. will always need to be in-the-loop for medical treatment. But AI technology can assist and present information for review to medical decision makers.
Properly developed and certified, healthcare assistance workload and errors can be reduced on non-complex issues, while improving outcomes.
Properly developed and certified, healthcare assistance workload and errors can be reduced on non-complex issues, while improving outcomes.
Reposted by Benjamin Pierce
1) New here, so a little introduction. We're a structural immunology group that focuses on T cell receptors, MHC proteins, antigen recognition, antigenicity etc. We work in the niche between structural biology, protein biophysics, and immunology.
🧪 #immunosky
🧪 #immunosky
November 15, 2024 at 2:02 PM
1) New here, so a little introduction. We're a structural immunology group that focuses on T cell receptors, MHC proteins, antigen recognition, antigenicity etc. We work in the niche between structural biology, protein biophysics, and immunology.
🧪 #immunosky
🧪 #immunosky
Reposted by Benjamin Pierce
Happy to see the Bluesky community growing!
If you're a fan of long-read sequencing technologies, make sure to follow the official #PacBio account (@pacbio.bsky.social).
There are also a few relevant starter packs to consider:
go.bsky.app/JGkefsJ
go.bsky.app/aKBj4a
go.bsky.app/3oiGMBe
If you're a fan of long-read sequencing technologies, make sure to follow the official #PacBio account (@pacbio.bsky.social).
There are also a few relevant starter packs to consider:
go.bsky.app/JGkefsJ
go.bsky.app/aKBj4a
go.bsky.app/3oiGMBe
November 18, 2024 at 11:17 PM
Happy to see the Bluesky community growing!
If you're a fan of long-read sequencing technologies, make sure to follow the official #PacBio account (@pacbio.bsky.social).
There are also a few relevant starter packs to consider:
go.bsky.app/JGkefsJ
go.bsky.app/aKBj4a
go.bsky.app/3oiGMBe
If you're a fan of long-read sequencing technologies, make sure to follow the official #PacBio account (@pacbio.bsky.social).
There are also a few relevant starter packs to consider:
go.bsky.app/JGkefsJ
go.bsky.app/aKBj4a
go.bsky.app/3oiGMBe
Reposted by Benjamin Pierce
My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.
November 20, 2024 at 4:15 PM
My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.