Author | Lightnews

Albert Martín @amartin88.bsky.social · 14d

@dbernardo-gut.bsky.social @uva-es.bsky.social @aegastro @sepdigestiva @seeceliaca @celiacscat @CeliacosMadrid @FACEceliacos @infoceliaco @CIBER_ISCIII

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Albert Martín @amartin88.bsky.social · 14d

9/9💡 Clinical message:
Negative antibodies ≠ mucosal healing.
New biomarkers are needed to monitor mucosal recovery in celiac disease.
🔗 Read the full paper: doi.org/10.1093/cei/...

Restoration of the lamina propria duodenal immune infiltrate in gluten-free diet treated celiac patients despite persistent villous atrophy

Most celiac disease patients despite following a gluten-free diet show mucosal alterations and/or symptomatology. However, duodenal immune infiltrate norma

doi.org

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Albert Martín @amartin88.bsky.social · 14d

8/9 Key takeaway:
📍 A strict GFD normalizes duodenal immune balance but not necessarily mucosal structure.
📍 IEL–epithelium interactions (esp. γδ T cells) may sustain the residual damage.

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Albert Martín @amartin88.bsky.social · 14d

7/9 Duration of the gluten-free diet correlated with:
⬆ Gut-homing markers (α4β7, CCR9, CCR2)
⬆ Effector T cells
⬇ Regulatory T cells
➡ Longer GFD = progressive immune normalization, even if mucosal healing lags behind.

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Albert Martín @amartin88.bsky.social · 14d

6/9 So, while the tissue architecture remained damaged, the immune environment of the lamina propria was restored.
This suggests that persistent atrophy may originate from the epithelial layer, not from immune cells in the lamina propria.

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Albert Martín @amartin88.bsky.social · 14d

5/9 Surprisingly, after >1 year on a GFD (average 7 years):
⚪ Serology was negative
⚪ 68% still had villous atrophy
⚪ Yet — the lamina propria immune infiltrate looked normal, nearly identical to controls

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Albert Martín @amartin88.bsky.social · 14d

4/9 At diagnosis, CD patients had:
🔸 Expansion of NK, ILC, B, Treg and Tγδ cells
🔸 Reduced CD4+ and CD8+ T cells
🔸 Strong pro-inflammatory phenotype (↑ Fas, CD38, CD2)
Classic picture of active mucosal inflammation.

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Albert Martín @amartin88.bsky.social · 14d

3/9 Researchers from Valladolid (Spain) analyzed duodenal biopsies from:
🔹 6 controls
🔹 6 newly diagnosed CD patients
🔹 19 GFD-treated CD patients
Using spectral flow cytometry, they mapped >70 immune cell subsets in the duodenal mucosa.

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Albert Martín @amartin88.bsky.social · 14d

2/9 Celiac disease (CD) affects ~1% of the population.
Even after years on a strict gluten-free diet (GFD), many patients still show intestinal villous atrophy — but the reasons remain unclear.

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Albert Martín @amartin88.bsky.social · 14d

🧵1/9 📢 New study in Clinical and Experimental Immunology (Fiz-López et al., 2025):
“Restoration of the duodenal lamina propria immune infiltrate in celiac patients on a gluten-free diet despite persistent villous atrophy.”
Here’s what they found 👇

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Reposted by Albert Martín

Universitat de Barcelona @ub.edu · Apr 4

#RecercaUB | 🦟 La investigadora Elisabet Tintó, en la seva tesi doctoral a la UB, va fer una descoberta sobre l’estratègia de defensa del paràsit que provoca la malària.

➡️ Ha guanyat el Premi Ramon Margalef del Consell Social i de la Fundació Bosch i Gimpera

tuit.cat/zqsn1

@isglobal.org

Elisabet Tintó, premiada per una descoberta sobre l’estratègia de defensa del paràsit de la malària

YouTube video by Universitat de Barcelona

www.youtube.com

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Reposted by Albert Martín

Gemma Ibáñez @gemmaibanez.bsky.social · Mar 13

El Dr Albert Martin @amartin88.bsky.social nos explica en el congreso de @aegastro.es la utilidad de la citometria de flujo en diferenciar los pacientes con #celiaquia 🌾 de bajo grado respecto a no celiacos. 😊

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Albert Martín @amartin88.bsky.social · Mar 12

La Dra. Carme Loras 👩‍⚕️ de @Mutua_Terrassa 🏥 nos explica las estenosis en la Enfermedad de Crohn 🤒, ¿dilatación, prótesis, otros tratamientos endoscópicos o cirugía? @aegastro.es #AEG2025

Reposted by Albert Martín

Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · Feb 6

ICYMI: New online! Understanding the therapeutic toolkit for inflammatory bowel disease

Understanding the therapeutic toolkit for inflammatory bowel disease

Nature Reviews Gastroenterology & Hepatology, Published online: 31 January 2025; doi:10.1038/s41575-024-01035-7The management of inflammatory bowel disease (IBD) continues to evolve. This Review is a practical guide on the therapeutic toolkit for IBD,…

www.nature.com

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Albert Martín @amartin88.bsky.social · Feb 7

5/ Want to learn more?
📖 Read the full study here: www.mdpi.com/1422-0067/26...
💬 Let’s discuss: What should be the gold standard for a healthy gut mucosa?
#Gastroenterology #Immunology #collaborativeresearch

Histology of the Upper Gastrointestinal Tract, Morphometry and Lymphocyte Subpopulations of the Duodenal Mucosa: Insights from Healthy Individuals

The upper oesophagogastrointestinal (UEGI) tract histology, intestinal morphometry and lymphocyte subpopulations of healthy people is scarcely known. In research studies of inflammation involving the ...

www.mdpi.com

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Albert Martín @amartin88.bsky.social · Feb 7

4/ Why does this matter?
🔹 Our study sets a “gold standard” for the normal histology of the upper digestive tract.
🔹 The immune profile of a truly healthy duodenum should guide future research and diagnostics.

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Albert Martín @amartin88.bsky.social · Feb 7

3/ Key findings:
✅ Healthy individuals had lower duodenal intraepithelial lymphocyte (IEL) counts than patients with gastroesophageal reflux disease (GERD) (15 vs. 19.5 per 100 enterocytes, p = 0.004).
✅ CD4+ T cells decreased (p = 0.008) & CD8+ T cells increased (p = 0.014) in GERD.

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Albert Martín @amartin88.bsky.social · Feb 7

2/ Most studies lack true healthy controls when investigating inflammatory diseases of the upper gastrointestinal tract. We rigorously selected asymptomatic individuals to establish a reference for future research.
🔬 #GutHealth #CeliacDisease #Endoscopy

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Albert Martín @amartin88.bsky.social · Feb 7

1/ What is normal in the upper digestive tract?🧐
Our latest study in @IJMS maps the histology of the esophagus, stomach, and duodenum, as well as morphometry and lymphocyte subpopulations of the duodenal mucosa in truly healthy individuals. A crucial step in defining a “gold standard” of normality🧵👇

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Reposted by Albert Martín

Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · Jan 29

ICYMI: New online! Coeliac disease: complications and comorbidities

Coeliac disease: complications and comorbidities

Nature Reviews Gastroenterology & Hepatology, Published online: 28 January 2025; doi:10.1038/s41575-024-01032-wIn this Review, Ludvigsson and colleagues describe the epidemiological associations between coeliac disease and a variety of complications and…

www.nature.com

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Albert Martín @amartin88.bsky.social · Jan 30

Vesícules extracel·lulars derivades de cèl·lules mare com a nou agent terapèutic per al tractament de la malaltia de Crohn 🧫🔬🧪🧬 Estudi molt interessant presentat a #SCD2025 @SCDigestologia @laura_clua @cserena79 @manye_j @IBODI_Group @IBDcanruti

Albert Martín @amartin88.bsky.social · Jan 30

AI applications in biomedicine research 🔬🧬💻🤖 Very interesting talk! Excellent presentation by @Davide__Cirillo at #SCD2025 @SCDigestologia @BSC_CNS

Albert Martín @amartin88.bsky.social · Jan 8

Leishmania 🦠 in patients with IBD 🤒 doesn't seem to follow a complicated clinical course, even in those with localized cutaneous leishmania who do not discontinue biological therapy 💉💊 after infection diagnosis.

Albert Martín @amartin88.bsky.social · Jan 8

Congratulations to @lmadero92 and @anaguticasbas for this excellent publication 👌🎯 @DHgua @geteccu @UEGJournal onlinelibrary.wiley.com/doi/10.1002/...

Leishmaniasis in Patients With Inflammatory Bowel Disease: A National Multicenter Study of GETECCU

Background Leishmaniasis (LI) is a vector-borne illness caused by a protozoan of the genus Leishmania. Data on the features of LI in patients with inflammatory bowel disease (IBD) are scarce. Aim ...

onlinelibrary.wiley.com

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Albert Martín @amartin88.bsky.social · Dec 3

🤗 Felicitats a la Dra. Elisabet Tintó Font i a tot el grup de recerca 🔬 @CortesMalaria pel #PremisUB Ramon Margalef de la @ub.edu @rectorub.bsky.social Un exemple de recerca de qualitat i un model a seguir 🧑‍🎓👌
www.nature.com/articles/s41...

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