Alexander Tesmer
@alexandertesmer.bsky.social
PhD student in the Burdakov lab at ETH Zürich. Multivalent decision-making in the hypothalamus.
In mice, orexin neurons multiplex the encoding of rapid body-movements with slow changes in blood glucose. The extent to which these neurons correlate with movement across behavioral and metabolic states surprised us! Now a Version of Record in @elife.bsky.social. doi.org/10.7554/eLif...
September 2, 2025 at 4:36 PM
In mice, orexin neurons multiplex the encoding of rapid body-movements with slow changes in blood glucose. The extent to which these neurons correlate with movement across behavioral and metabolic states surprised us! Now a Version of Record in @elife.bsky.social. doi.org/10.7554/eLif...
Reposted by Alexander Tesmer
In our Learning Club @cmc-lab.bsky.social tomorrow (= July 3rd, Thursday, 2 PM CET), @alexandertesmer.bsky.social will tell us about his recent paper (bsky.app/profile/alex...). If you'd like to attend, send an empty email to [email protected] to get the link!
July 2, 2025 at 12:12 PM
In our Learning Club @cmc-lab.bsky.social tomorrow (= July 3rd, Thursday, 2 PM CET), @alexandertesmer.bsky.social will tell us about his recent paper (bsky.app/profile/alex...). If you'd like to attend, send an empty email to [email protected] to get the link!
Hunger-driving AgRP neurons are REM-active, and similarly re-activate during cataplexy. Hot off the press from the Burdakov lab! www.biorxiv.org/content/10.1...
A rapid arousal brake on hunger neurons and its release in narcolepsy
Human sleep-wake disorders are often accompanied by eating disorders; the reasons for this apparent interplay between hunger and arousal remain unclear. Pupil-linked arousal fluctuates second-by-secon...
www.biorxiv.org
March 12, 2025 at 9:37 AM
Hunger-driving AgRP neurons are REM-active, and similarly re-activate during cataplexy. Hot off the press from the Burdakov lab! www.biorxiv.org/content/10.1...
Policy complexity is expensive. How does the brain regulate its investment of cognitive capacity? Our newest paper is on BioRxiv! We examine hypothalamic orexin (and MCH!) -producing neurons for their role in regulating the complexity decision policies. www.biorxiv.org/content/10.1...
Neurometabolic signaling and control of policy complexity
Cognition and adaptive behavior emerge from neural information processing. This must operate within finite metabolic constraints, since neural information processing is metabolically expensive. While ...
www.biorxiv.org
February 26, 2025 at 2:23 AM
Policy complexity is expensive. How does the brain regulate its investment of cognitive capacity? Our newest paper is on BioRxiv! We examine hypothalamic orexin (and MCH!) -producing neurons for their role in regulating the complexity decision policies. www.biorxiv.org/content/10.1...
Reviewed preprint is online in @elife.bsky.social: Reviewers raised some important points, revisions coming soon!
Orexin population activity precisely reflects net body movement across behavioral and metabolic states doi.org/10.7554/eLif...
Orexin population activity precisely reflects net body movement across behavioral and metabolic states doi.org/10.7554/eLif...
Orexin population activity precisely reflects net body movement across behavioral and metabolic states
doi.org
February 7, 2025 at 4:14 PM
Reviewed preprint is online in @elife.bsky.social: Reviewers raised some important points, revisions coming soon!
Orexin population activity precisely reflects net body movement across behavioral and metabolic states doi.org/10.7554/eLif...
Orexin population activity precisely reflects net body movement across behavioral and metabolic states doi.org/10.7554/eLif...
Reposted by Alexander Tesmer
Distinct bandwidths of orexin neuron activity independently encode body movement and metabolic state https://www.biorxiv.org/content/10.1101/2024.08.13.607750v1
Distinct bandwidths of orexin neuron activity independently encode body movement and metabolic state https://www.biorxiv.org/content/10.1101/2024.08.13.607750v1
Hypothalamic orexin/hypocretin neurons (HONs) are key orchestrators of metabolism and adaptive behav
www.biorxiv.org
August 16, 2024 at 11:15 PM
Distinct bandwidths of orexin neuron activity independently encode body movement and metabolic state https://www.biorxiv.org/content/10.1101/2024.08.13.607750v1