Adrian
@aconga.bsky.social
PostDoc at EEP-Lille. Interested in the repetitive, but complex, fraction that make up most of the genomes. Fan del Sol
Reposted by Adrian
The first paper of my PhD is now available as a preprint! 🎉
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
www.biorxiv.org
June 20, 2025 at 7:39 PM
The first paper of my PhD is now available as a preprint! 🎉
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
Reposted by Adrian
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen - Nature Communications
In this study, the authors analysed a large genomic dataset to trace how jumping genes shaped the global spread of a major wheat pathogen and reveal bursts of activity over decades that drove adaptati...
www.nature.com
November 12, 2025 at 1:17 PM
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Reposted by Adrian
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
November 12, 2025 at 4:01 PM
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
Reposted by Adrian
If you're in Ghent tomorrow ! I'll be sharing our recent progress deciphering the sRNA-based dominance/recessivity interactions at the self-incompatibility locus in Arabidopsis 🌱
TOMORROW: SEMINAR by @vincentcastric.bsky.social from @univlille.bsky.social @cnrs.fr, invited by @pnovik.bsky.social and @yvdp.bsky.social. @viblifesciences.bsky.social
November 12, 2025 at 10:12 AM
If you're in Ghent tomorrow ! I'll be sharing our recent progress deciphering the sRNA-based dominance/recessivity interactions at the self-incompatibility locus in Arabidopsis 🌱
Reposted by Adrian
🚀 philentropy v0.10.0 is on CRAN!
Now with long-awaited parallel distance computation & a full speed-optimized refactor thanks to Andrew Gene Brown.
Compute 50+ distances/divergences in R faster than ever.
📦 CRAN: cran.r-project.org/web/packages...
💻 Code: github.com/drostlab/phi...
Now with long-awaited parallel distance computation & a full speed-optimized refactor thanks to Andrew Gene Brown.
Compute 50+ distances/divergences in R faster than ever.
📦 CRAN: cran.r-project.org/web/packages...
💻 Code: github.com/drostlab/phi...
November 4, 2025 at 9:31 AM
🚀 philentropy v0.10.0 is on CRAN!
Now with long-awaited parallel distance computation & a full speed-optimized refactor thanks to Andrew Gene Brown.
Compute 50+ distances/divergences in R faster than ever.
📦 CRAN: cran.r-project.org/web/packages...
💻 Code: github.com/drostlab/phi...
Now with long-awaited parallel distance computation & a full speed-optimized refactor thanks to Andrew Gene Brown.
Compute 50+ distances/divergences in R faster than ever.
📦 CRAN: cran.r-project.org/web/packages...
💻 Code: github.com/drostlab/phi...
Reposted by Adrian
Interested in doing a PhD? The TREES doctoral training program is now open for applications!
🌱 PhD Applications Open – TREES Doctoral Training Programme
TREES (Doctoral Landscape Alliance) is now accepting applications for fully funded PhD studentships in UKRI-NERC science remit.
🔗 trees-dla.ac.uk
#PhDOpportunity #AcademicTwitter #Ecology #ClimateResearch #PhDApplications
TREES (Doctoral Landscape Alliance) is now accepting applications for fully funded PhD studentships in UKRI-NERC science remit.
🔗 trees-dla.ac.uk
#PhDOpportunity #AcademicTwitter #Ecology #ClimateResearch #PhDApplications
Home | TREES DLA
TREES is a dynamic new programme for doctoral training designed to equip the next generation of environmental scientists to tackle today's critical global challenges. Sign up to the TREES mailing…
trees-dla.ac.uk
October 29, 2025 at 8:26 AM
Interested in doing a PhD? The TREES doctoral training program is now open for applications!
Reposted by Adrian
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
A comparative analysis of transposable element diversity and evolution across 75 bee genomes - BMC Genomics
Transposable elements (TEs) are repetitive DNA sequences that can alter their position and abundance within genomes. While TEs are known to have various impacts on genome structure and function, our u...
doi.org
November 6, 2025 at 1:29 PM
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
Reposted by Adrian
Only a few days left to register and join us in Lille for this first ever French edition of PopGroup!
Hi Folks !
Just a few more days to register for the POPGROUP meeting (deadline = this Monday 10/11/2025).
Join us in the beautiful city of #Lille just across the Channel for three exciting days of science and more !
www.hautsdefrancetourism.com/destinations...
--> populationgeneticsgroup.org.uk
Just a few more days to register for the POPGROUP meeting (deadline = this Monday 10/11/2025).
Join us in the beautiful city of #Lille just across the Channel for three exciting days of science and more !
www.hautsdefrancetourism.com/destinations...
--> populationgeneticsgroup.org.uk
November 5, 2025 at 9:49 AM
Only a few days left to register and join us in Lille for this first ever French edition of PopGroup!
Hermaphroditic plants also use TIME ⏰🌿 to avoid selfing.
Two new @currentbiology.bsky.social papers explore the rapid turnover of this trait in the wingnut family.
Both @vincentcastric.bsky.social and I summarized these findings 👉 authors.elsevier.com/a/1m2MA3QW8S...
#Evolution #PlantBiology
Two new @currentbiology.bsky.social papers explore the rapid turnover of this trait in the wingnut family.
Both @vincentcastric.bsky.social and I summarized these findings 👉 authors.elsevier.com/a/1m2MA3QW8S...
#Evolution #PlantBiology
November 4, 2025 at 7:30 PM
Hermaphroditic plants also use TIME ⏰🌿 to avoid selfing.
Two new @currentbiology.bsky.social papers explore the rapid turnover of this trait in the wingnut family.
Both @vincentcastric.bsky.social and I summarized these findings 👉 authors.elsevier.com/a/1m2MA3QW8S...
#Evolution #PlantBiology
Two new @currentbiology.bsky.social papers explore the rapid turnover of this trait in the wingnut family.
Both @vincentcastric.bsky.social and I summarized these findings 👉 authors.elsevier.com/a/1m2MA3QW8S...
#Evolution #PlantBiology
Reposted by Adrian
Why do complex traits differ in their genetic architecture?
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
Simple scaling laws control the genetic architectures of human complex traits
Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...
journals.plos.org
October 24, 2025 at 1:51 AM
Why do complex traits differ in their genetic architecture?
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
Reposted by Adrian
what you always wanted to know about the molecular choreography of nuclear mRNA packaging and export.
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
Mechanisms of Messenger RNA Packaging and Export
The packaging and export of messenger RNA (mRNA) are essential cellular pathways that bridge the nuclear and cytoplasmic phases of eukaryotic gene expression. During their nuclear maturation, mRNAs ar...
www.annualreviews.org
October 18, 2025 at 3:08 PM
what you always wanted to know about the molecular choreography of nuclear mRNA packaging and export.
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
Reposted by Adrian
Amazing!!
Congrats to the team for uncovering this link
We are all phages …
Regular reminder to the “The frustrated gene” article from @hitenmadhani.bsky.social
Congrats to the team for uncovering this link
We are all phages …
Regular reminder to the “The frustrated gene” article from @hitenmadhani.bsky.social
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
www.biorxiv.org
October 17, 2025 at 6:41 PM
Amazing!!
Congrats to the team for uncovering this link
We are all phages …
Regular reminder to the “The frustrated gene” article from @hitenmadhani.bsky.social
Congrats to the team for uncovering this link
We are all phages …
Regular reminder to the “The frustrated gene” article from @hitenmadhani.bsky.social
Reposted by Adrian
It may look like CGI, but this is the real deal: It's an accurate 3D rendering of our galactic neighborhood, highlighting the locations where new stars are being born.
This animation is based on measurements of 44 million stars by the Gaia space telescope. 🧪🔭
www.esa.int/Science_Expl...
This animation is based on measurements of 44 million stars by the Gaia space telescope. 🧪🔭
www.esa.int/Science_Expl...
October 16, 2025 at 5:16 PM
It may look like CGI, but this is the real deal: It's an accurate 3D rendering of our galactic neighborhood, highlighting the locations where new stars are being born.
This animation is based on measurements of 44 million stars by the Gaia space telescope. 🧪🔭
www.esa.int/Science_Expl...
This animation is based on measurements of 44 million stars by the Gaia space telescope. 🧪🔭
www.esa.int/Science_Expl...
Reposted by Adrian
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons - ScienceDirect https://www.sciencedirect.com/science/article/pii/S0092867425010359?dgcid=rss_sd_all
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
Transposon-encoded TnpB nucleases gave rise to type V CRISPR-Cas12 effectors through multiple independent domestication events. These systems use diff…
www.sciencedirect.com
October 1, 2025 at 12:06 AM
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons - ScienceDirect https://www.sciencedirect.com/science/article/pii/S0092867425010359?dgcid=rss_sd_all
Reposted by Adrian
I heard James talking to @mrjamesob.bsky.social earlier & on the back of that, I’ve decided to subscribe to @thenewworldmag.bsky.social
They’re doing 10 weeks for £10! A bargain for such brilliant journalism. Sign up if you can 👏
They’re doing 10 weeks for £10! A bargain for such brilliant journalism. Sign up if you can 👏
You might think controlling GB News gives you huge influence over UK politics – especially on the right. But that's just the tip of the iceberg, as we reveal in this week's issue of @thenewworldmag.bsky.social
Full story: www.thenewworld.co.uk/james-ball-p...
Full story: www.thenewworld.co.uk/james-ball-p...
October 16, 2025 at 4:53 PM
I heard James talking to @mrjamesob.bsky.social earlier & on the back of that, I’ve decided to subscribe to @thenewworldmag.bsky.social
They’re doing 10 weeks for £10! A bargain for such brilliant journalism. Sign up if you can 👏
They’re doing 10 weeks for £10! A bargain for such brilliant journalism. Sign up if you can 👏
Reposted by Adrian
Sharing our new paper, "Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts". Genomics & evolution of a mating type system involving two morphs with alternating sexes in walnut relatives www.cell.com/current-biol...
Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts
In most species within the walnut family, two genetically determined morphs alternate
between male and female flowering phases in time. Groh et al. identify a distinct
locus for this dimorphism in two...
www.cell.com
October 16, 2025 at 3:43 PM
Sharing our new paper, "Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts". Genomics & evolution of a mating type system involving two morphs with alternating sexes in walnut relatives www.cell.com/current-biol...
Reposted by Adrian
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
October 10, 2025 at 12:57 PM
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
Reposted by Adrian
Have you ever wondered why pumpkins are never purple or blue like other plants? 🎃🌈
While most plants can produce pink, blue, and purple pigments (thanks to anthocyanins), the Cucurbitaceae family 🍈 🍉 🥒have lost all the pathway genes to produce these pigments.
🔗 doi.org/10.1101/2025...
While most plants can produce pink, blue, and purple pigments (thanks to anthocyanins), the Cucurbitaceae family 🍈 🍉 🥒have lost all the pathway genes to produce these pigments.
🔗 doi.org/10.1101/2025...
October 10, 2025 at 11:35 AM
Have you ever wondered why pumpkins are never purple or blue like other plants? 🎃🌈
While most plants can produce pink, blue, and purple pigments (thanks to anthocyanins), the Cucurbitaceae family 🍈 🍉 🥒have lost all the pathway genes to produce these pigments.
🔗 doi.org/10.1101/2025...
While most plants can produce pink, blue, and purple pigments (thanks to anthocyanins), the Cucurbitaceae family 🍈 🍉 🥒have lost all the pathway genes to produce these pigments.
🔗 doi.org/10.1101/2025...
Reposted by Adrian
If that’s not enough, we threw in a complete, T2T giraffe genome! Giraffe genomes are pretty cool. Almost all of their chromosomes are Robertsonian fusions of the typically telocentric ruminant chromosomes. 🐄 vs. 🦒...
October 10, 2025 at 3:26 PM
If that’s not enough, we threw in a complete, T2T giraffe genome! Giraffe genomes are pretty cool. Almost all of their chromosomes are Robertsonian fusions of the typically telocentric ruminant chromosomes. 🐄 vs. 🦒...
Reposted by Adrian
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 8, 2025 at 4:31 PM
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Reposted by Adrian
Im trying this thing where I use floral dip buffer (with silwet added) as the co-culture buffer for when exposing leaf disks to agrobacterium. My thinking is it helps bring agro closer to wounded tissue by breaking surface tension on hairly leaf bits. Gonna try a few times n see.
October 4, 2025 at 2:14 AM
Im trying this thing where I use floral dip buffer (with silwet added) as the co-culture buffer for when exposing leaf disks to agrobacterium. My thinking is it helps bring agro closer to wounded tissue by breaking surface tension on hairly leaf bits. Gonna try a few times n see.
Reposted by Adrian
We discovered an endogenous retrovirus that's still spreading in natural D. melanogaster populations! It was horizontally transferred from D. erecta in Central Africa, so we named it "Kuruka", which means "jump" in Swahili. Read its cool story here: www.biorxiv.org/content/10.1...
October 4, 2025 at 5:50 AM
We discovered an endogenous retrovirus that's still spreading in natural D. melanogaster populations! It was horizontally transferred from D. erecta in Central Africa, so we named it "Kuruka", which means "jump" in Swahili. Read its cool story here: www.biorxiv.org/content/10.1...
Reposted by Adrian
#Solar becomes main source of electricity in the #EU for first time. More than half of the EU’s #electricity in the second quarter of 2025 came from #RenewableEnergy
www.independent.co.uk/tech/solar-p...
www.independent.co.uk/tech/solar-p...
Solar becomes main source of electricity in the EU for first time
More than half of the EU’s electricity in the second quarter of 2025 came from renewable energy
www.independent.co.uk
October 3, 2025 at 9:15 AM
#Solar becomes main source of electricity in the #EU for first time. More than half of the EU’s #electricity in the second quarter of 2025 came from #RenewableEnergy
www.independent.co.uk/tech/solar-p...
www.independent.co.uk/tech/solar-p...
Reposted by Adrian
Cool presentation by @jefowlerjr.bsky.social using high-throughput GFP transposon tagging to identify genes that affect pollen viability/competition, from this week's #Zeavolution youtu.be/BxiT2MCNYUQ
Successfully Predictive Modeling of Pollen Fitness Is Enabled by Measures of Expression Specificity
YouTube video by Zeavolution
youtu.be
October 3, 2025 at 8:02 PM
Cool presentation by @jefowlerjr.bsky.social using high-throughput GFP transposon tagging to identify genes that affect pollen viability/competition, from this week's #Zeavolution youtu.be/BxiT2MCNYUQ
Reposted by Adrian
So happy to see my first first-author paper published! 🎈
A short thread on how Ectocarpus and its TE secrets have kept me busy lately:
rdcu.be/eITQH
A short thread on how Ectocarpus and its TE secrets have kept me busy lately:
rdcu.be/eITQH
Characterization of the transposable element landscape shaping the Ectocarpus genome | Genome Biology
rdcu.be
October 1, 2025 at 8:12 AM
So happy to see my first first-author paper published! 🎈
A short thread on how Ectocarpus and its TE secrets have kept me busy lately:
rdcu.be/eITQH
A short thread on how Ectocarpus and its TE secrets have kept me busy lately:
rdcu.be/eITQH