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Wout Oosterheert

@woutoosterheert.bsky.social

110 followers 95 following 17 posts

Junior group leader at the Netherlands Cancer Institute (NKI) in Amsterdam. Interests include biochemistry; structural biology; cryo-EM; the cytoskeleton; membrane proteins.

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Wout Oosterheert @woutoosterheert.bsky.social · 2d

Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.

www.sciencedirect.com/science/arti...

Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.

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Wout Oosterheert @woutoosterheert.bsky.social · 13h

Thank you 😁

Wout Oosterheert @woutoosterheert.bsky.social · 1d

Thank you, hope all is well in Berlin! 😃

Wout Oosterheert @woutoosterheert.bsky.social · 2d

Although I was 6 years old at the time - your papers were still very useful for this new work 😄

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Wout Oosterheert @woutoosterheert.bsky.social · 2d

Thank you for appreciating our work!

Wout Oosterheert @woutoosterheert.bsky.social · 2d

Thanks Lennart 😄

Wout Oosterheert @woutoosterheert.bsky.social · 2d

This is a perfect farewell to the @mpi-dortmund.bsky.social and the @raunser-lab.bsky.social. Big thanks to the whole team 😁.

Interested in doing equally exciting work? I have open positions available soon in my newly established lab at the @nkinl.bsky.social in Amsterdam.

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Wout Oosterheert @woutoosterheert.bsky.social · 2d

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Reposted by Wout Oosterheert

cryoEM papers @cryoempapers.bsky.social · 2d

Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1 pubmed.ncbi.nlm.nih.gov/41075793/ #cryoem

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Reposted by Wout Oosterheert

Tobias Raisch @traisch.bsky.social · 27d

We just published this paper of which I am immensely proud: www.nature.com/articles/s41...

In the study, we uncover how the enzyme MPO disassembles #nucleosomes in a process called NETosis, a funky mechanism of #neutrophils to kill #pathogens that you might have never heard of.

Let's dive in... 🧵

Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature

Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

www.nature.com

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Wout Oosterheert @woutoosterheert.bsky.social · 15d

My final postdoctoral work will come out very soon, so watch this space 🧐.

In Amsterdam, I aim to decipher the molecular mechanisms of (cancer)-cell migration and adhesion using structural biology approaches. Positions available soon, so please reach out when you are interested! 😁

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Wout Oosterheert @woutoosterheert.bsky.social · 15d

This marks the end of >4.5 years as a postdoctoral researcher at the @mpi-dortmund.bsky.social. Massive thanks to my advisor @raunser-lab.bsky.social for the invaluable guidance and support; and the entire department for making it an unforgettable experience!

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Wout Oosterheert @woutoosterheert.bsky.social · 15d

Thrilled to announce that from tomorrow (October 1st), I'll start as a junior group leader at the Netherlands Cancer Institute (NKI) @nkinl.bsky.social in Amsterdam 😄.

www.nki.nl/news-events/...

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New group leader Wout Oosterheert: the devil is in the details | Netherlands Cancer Institute

www.nki.nl

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Reposted by Wout Oosterheert

Tassos Perrakis @tassosperrakis.bsky.social · Sep 13

Featuring #AlphaBridge features from @alvarezsalmoral.bsky.social, with @jonasteuwen.bsky.social and team, our new work from @nkinl.bsky.social nl.bsky.social @oncodeinstitute.bsky.social . Have a look at ahmpc.eu for more!

bioRxivpreprint @biorxivpreprint.bsky.social · Sep 13

Integrating computational protein structure predictions and genetic dependencies yields an atlas of human multi-protein complexes (AHMPC) https://www.biorxiv.org/content/10.1101/2025.09.09.675133v1

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Reposted by Wout Oosterheert

Nature @nature.com · Aug 23

Nature research paper: Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases

go.nature.com/3HpdTqq

Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases - Nature

Structural insights into ultrafast Ca2+ transport by plasma membrane Ca2+-ATPases are provided, highlighting an essential role for PtdIns(4,5)P2 dynamics.

go.nature.com

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Wout Oosterheert @woutoosterheert.bsky.social · Aug 25

The video takes more than half a minute for illustrative purposes. However, these PMCA2-NPTN complexes can in reality pump calcium out of the cell at a speed of 5,000 (! 🤯) ions per second.

Wout Oosterheert @woutoosterheert.bsky.social · Aug 25

Happy to have made a tiny contribution to this work (including the shown movie 😄). Amazing work by Fakler lab @uni-freiburg.de and @raunser-lab.bsky.social @mpi-dortmund.bsky.social about Ca-ion transport by PMCA2-NPTN complexes, now out in @nature.com

www.nature.com/articles/s41...

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Reposted by Wout Oosterheert

Carter Lab @carter-lab.bsky.social · Aug 5

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

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Wout Oosterheert @woutoosterheert.bsky.social · Feb 18

Great story, congratulations!

Reposted by Wout Oosterheert

Alushin Lab @alushinlab.bsky.social · Feb 18

Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in Science Advances: bit.ly/3EFpD6h

Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature

Afadin strengthens adherens junctions by stabilizing cadherin-catenin complex clusters on curved F-actin.

bit.ly

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Wout Oosterheert @woutoosterheert.bsky.social · Feb 4

Cool story, congrats!!

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Reposted by Wout Oosterheert

Tianyang Liu @tianyang22.bsky.social · Jan 31

Working on actin cytoskeleton and Arp2/3 complex? Check out our latest work～https://www.biorxiv.org/content/10.1101/2025.01.31.635869v1
In this work, we found SPIN90 forms a dimer, facilitating bidirectional actin filament nucleation by activating two Arp2/3 complex #Cryo-EM #Actin #Arp2/3

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Wout Oosterheert @woutoosterheert.bsky.social · Jan 25

Thank you 😁!

Wout Oosterheert @woutoosterheert.bsky.social · Jan 23

Danke schön mein Sohn. Hope everything is well in Boston.

Wout Oosterheert @woutoosterheert.bsky.social · Jan 23

My first post on this forum! 😄

I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social

www.cell.com/trends/cell-...

Big thanks to my amazing colleagues in Dortmund

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