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Reposted by Vicky Lioy

Stephan Gruber @gruberlab.bsky.social · 6d

How do SMC complexes load onto DNA to get ready for loop extrusion?

@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️.

Check out the new paper: www.cell.com/molecular-ce...

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Reposted by Vicky Lioy

Chloe Girard, PhD @chloegirard.bsky.social · 14d

🚨 First pre-print from my team !!

TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !

The recombination frequency (cM/Mb) along chromosome 4 of A. thaliana (female meiosis).

In full hybrids (grey), where polymorphism is distributed all along chromosomes, most crossovers occur in the regions surrounding the Centromere (Cen), and very few at chromosome ends (Tel: telomeres).

In lines where polymorphism is restricted to chromosome ends (purple), the local recombination rate increases drastically, at the expense of the non-polymorphic regions (yellow).

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Reposted by Vicky Lioy

Géraldine Laloux @lalouxlab.bsky.social · 20d

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle

The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

www.biorxiv.org

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Reposted by Vicky Lioy

Emma Waters @emmabeansworth.bsky.social · 26d

The @yorkmuseumstrust.bsky.social's Hospitium was such a lovely location for the @biochemsoc.bsky.social #BioPhyChrom2025 conference dinner. Gorgeous gardens, fabulous food & captivating conversations

Thank you to the organisers for creating a great program & friendly interdisciplinary environment

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Vicky Lioy @vslioy.bsky.social · 25d

This also happened at #BioPhyChrom2025, congratulations @ceesdekker.bsky.social

@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social

Cees Dekker @ceesdekker.bsky.social · 26d

As in so many ways I very much still feel like a novice student in exploring biology, I am very grateful and proud for this Award of the Biochemical Society 'for significant achievements in nanoscale molecular biology, especially the contribution to developing methodologies'.

Biochemical Society @biochemsoc.bsky.social · 26d

Congratulations to Cees Dekker @ceesdekker.bsky.social who showcased his work on single-molecule biophysics studies of DNA loop extrusion in his 2026 #BiochemAward Lecture for Significant Breakthrough or Achievement! We hope everyone enjoyed Prokaryotic Chromosomes VII!

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Reposted by Vicky Lioy

Romain Koszul @rkoszul.bsky.social · 26d

New paper!
We generated and/or (re)analyzed ~100 #metagenomics Hi-C datasets to provide a comprehensive analysis of bacterial and viral metagenomes across VERY different environments.
Congratulations to all authors especially Amaury Bignaud and @mmarbout.bsky.social for the huge work!
#metaHiC

Martial Marbouty @mmarbout.bsky.social · 26d

You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range.
@rkoszul.bsky.social @natmicrobiol.nature.com @cnrs.fr @institutpasteur.bsky.social

www.nature.com/articles/s41...

Phages with a broad host range are common across ecosystems - Nature Microbiology

Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.

www.nature.com

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Reposted by Vicky Lioy

Biochemical Society @biochemsoc.bsky.social · 26d

That’s a wrap for The Biology and Physics of Prokaryotic Chromosomes VII 2025. A big thank you to all those who attended 🧪 #BioPhyChrom2025 #BiochemEvents

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Vicky Lioy @vslioy.bsky.social · 25d

#Biophychrom2025 is over, but we spent four exciting days discussing the biology and physics of prokaryotic chromosomes. Congratulations to all the attendees for making this conference a success.
@biochemsoc.bsky.social
@danielabarilla.bsky.social
@graingerlab.bsky.social
@damelab.bsky.social

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Reposted by Vicky Lioy

Daniela Barillà @danielabarilla.bsky.social · 26d

#BioPhyChrom25 gala dinner at the 14th century #Hospitium venue in York, and @agnesnoy.bsky.social talk. Lots of discussion and ideas for BioPhyChrom2027… Great vibes and atmosphere!
@biophychrom.bsky.social @damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social 🧬

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Emma Waters @emmabeansworth.bsky.social · 26d

Well that's a wrap @biochemsoc.bsky.social #BioPhyChrom2025 thank you to the organisers & everyone here for contributing to a wonderful week. Looking forward to hopefully seeing you all again in Paris 🇫🇷

@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@vslioy.bsky.social

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Reposted by Vicky Lioy

Langridge Lab @langridgelab.bsky.social · 28d

We have been hearing great things about @biochemsoc.bsky.social #BioPhyChrom2025 & it looks like our Emma is having fun.. maybe too much?😉

Don't worry when she's back she will be writing a paper on this work showing that genomic rearrangement can impact #virulence & #AMR. Find Poster 9 to hear more

Emma Waters @emmabeansworth.bsky.social · 29d

What a great 1st session @biochemsoc.bsky.social #BioPhyChrom2025. A great mix of talks & discussion points from all speakers

I am looking forward to sharing my work showing that genome structure variation can influence #virulence & #AMR. Come see me at poster 009

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Reposted by Vicky Lioy

Grainger Lab @graingerlab.bsky.social · 29d

@danielabarilla.bsky.social kicking off #BioPhyChrom2025 - a fantastic turn out too...

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Reposted by Vicky Lioy

Emma Waters @emmabeansworth.bsky.social · 29d

Who's ready for an exciting week ahead in York @biochemsoc.bsky.social's Biology & physics of Prokaroytic Chromosomes?! #BioPhyChrom2025

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Reposted by Vicky Lioy

Biochemical Society @biochemsoc.bsky.social · 29d

A big welcome to the attendees of The Biology and Physics of Prokaryotic Chromosomes VII. We’re looking forward to bringing together the community in York #BiochemEvent #BioPhyChrom2025

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Reposted by Vicky Lioy

Emma Waters @emmabeansworth.bsky.social · 29d

What a great 1st session @biochemsoc.bsky.social #BioPhyChrom2025. A great mix of talks & discussion points from all speakers

I am looking forward to sharing my work showing that genome structure variation can influence #virulence & #AMR. Come see me at poster 009

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Vicky Lioy @vslioy.bsky.social · 29d

Finally in York! Tomorrow is D-Day #BioPhyChrom2025 kicks off with a great program and posters!

@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social

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Vicky Lioy @vslioy.bsky.social · 29d

Thank you a lot for the invitation! I had a wonderful day and loved discussing with @gemma-langridge.bsky.social and all of you today!

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Reposted by Vicky Lioy

Christophe Le Clainche @actin-paris-saclay.bsky.social · Sep 12

This week we are celebrating the 10th anniversary of the I2BC — very proud of what we have accomplished together! www.i2bc.paris-saclay.fr

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Vicky Lioy @vslioy.bsky.social · Sep 14

Looking forward to it!

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Vicky Lioy @vslioy.bsky.social · Sep 14

UK mode ON 🇬🇧 #BioPhyChrom2025 ahead! First stop @quadraminstitute.bsky.social for some Salmonella chromatin chats with @emmabeansworth.bsky.social & @langridgelab.bsky.social

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Reposted by Vicky Lioy

Daniela Barillà @danielabarilla.bsky.social · Sep 13

The countdown for #BioPhyChrom2025 is nearly over: -2 days to go… What a fête of chromosome biology & physics!🧬

Safe journey everyone! ✈️🚂
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

www.eventsforce.net/biochemsoc/f...

Front entrance to York Minster cathedral with a blue sky background.

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Vicky Lioy @vslioy.bsky.social · Sep 13

🚨 Open position: A 2-year engineer/postdoc position will be available in Julie Soutourina’s group at #GenomeBiologyI2BC. The project focuses on Mediatorpathies, rare neurodevelopmental diseases, using yeast and human cell models with genomics and bioinformatics approaches. More info and contact 👇

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Vicky Lioy @vslioy.bsky.social · Sep 13

Thank you for visiting us! It was great! See you soon!

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Vicky Lioy @vslioy.bsky.social · Sep 12

Celebrating the 10 years of the @i2bcparissaclay.bsky.social with an excellent program of talks! Happy birthday I2BC !!🎊 🎂

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Vicky Lioy @vslioy.bsky.social · Sep 9

Looking forward to this great meeting and glad to have the chance to share our work on #BacterialChromatin 🧫🧬

Tobias Warnecke @tobiaswarnecke.bsky.social · Sep 8

Please re-post:

Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...

Abstract deadline: 30 September

EvoChromo: Evolutionary approaches to research in chromatin

Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…

meetings.embo.org

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