👏 A huge congratulations to Brunkow, Ramsdell, and Sakaguchi for helping us better understand the delicate balance of immunity and tolerance. The immune system’s true sophistication lies in its ability to distinguish between threat and self—and to choose peace when needed.
Why does this matter? 🔹 It opens new doors to treating autoimmune diseases 🔹 It helps improve cancer therapies by fine-tuning immune responses 🔹 It reduces complications in stem cell transplants
Their work revealed how the body maintains "peripheral immune tolerance," which means teaching immune cells to tolerate our own tissues even outside the central training zone (the thymus).
The Nobel-winning trio uncovered a critical part of the immune system called regulatory T cells. Think of them as peacekeepers or referees. These cells help the immune system stay calm and avoid friendly fire.
In simple terms: our immune system is like a powerful security force. It’s trained to detect and destroy invaders like viruses and bacteria. But sometimes, it gets confused and starts attacking our own healthy cells. This is what happens in autoimmune diseases like type 1 diabetes, lupus, or MS
🧬✨ Big news from the world of science: The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their groundbreaking discoveries about how our immune system knows when not to attack.
📌 Bottom Line: Whether you're decoding rare variants or just curious about the future of medicine, this project is a powerful reminder of how science and data can come together to improve lives. 🔗 You can explore the full study here: www.nature.com/articles/s41....
💡 For Everyone Else: • Think of this as a giant genetic encyclopedia—built from real people—that helps scientists understand why some people get sick and others don’t.
• Researchers conducted cross-ancestry analyses, uncovering novel disease associations in individuals of African and Asian descent, not just European populations.
🔍 For Scientists: • This dataset captures coding and non-coding regions, structural variants, and rare mutations that older genotyping and exome sequencing methods often miss.
🧬 A Landmark in Human Genomics—For Researchers and Everyone Else The UK Biobank has just completed whole-genome sequencing for nearly half a million participants, creating one of the most comprehensive genetic datasets in the world.
Proud to be part of an organization that supports these efforts with the tools and expertise needed to turn possibility into progress. Because rare diseases aren’t rare when they affect someone you care about—or someone just like Gunnar. #KIF1A#nLorem#RareDisease#Cytiva#PatientStories#Genomics
Gunnar’s journey with KIF1A-associated neurological disorder is a powerful example of how personalized medicine can bring hope where options are few. The work that Cytiva and the n-Lorem Foundation are doing to develop a custom ASO therapy is nothing short of inspiring.
@cytiva.bsky.social This story hits close to home. As someone who works closely with motor proteins, I’m often reminded that science isn’t just about data—it’s about people.
📌 Bottom Line: Exercise is essential, but like anything, balance matters. It is important to understand how the heart adapts to physical demands—and why recovery and monitoring are key for those pushing their limits. Read more here: lnkd.in/ecF5ta43
🧠 Why It Matters: Most heart research focuses on the left ventricle (the side that pumps blood to the body), but studies now show that the right ventricle also adapts—and sometimes struggles—under extreme physical stress.
🔍 Key Takeaway: While exercise is great for heart health, extreme endurance efforts can cause the right ventricle to stretch and weaken temporarily, a phenomenon known as exercise-induced cardiac remodeling.