Lightnews — Scholar-powered news

Trevor Graham @trevorgraham.bsky.social · 10h

Both projects involve lots of collaboration, supervision, mentorship and training (& travel!) across our @evomg-dn.bsky.social network. They mandate motility across the #EU and partner countries too. Consequently I think the studentships will offer exceptionally rich #PhD experiences.

1 1

Trevor Graham @trevorgraham.bsky.social · 10h

The second is about potential fitness costs of cancer drug resistance, and how we might exploit them using approaches like adaptive therapy. (building on our work with @mlockley.bsky.social in ovarian cancer: aacrjournals.org/cancerres/ar...). Description here: www.icr.ac.uk/study-and-ca...

Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control

Carboplatin adaptive therapy improves treatment efficacy without increasing daily dose due to reduced fitness of drug-resistant populations, which can be tracked using cfDNA and could direct adaptive ...

aacrjournals.org

1 4 5

Trevor Graham @trevorgraham.bsky.social · 10h

The first is about developing new approaches to track cancer evolution from cell free DNA (cfDNA - liquid biopsy), and is a collaboration with industry partner nonacus.com Description here: www.icr.ac.uk/study-and-ca...

1 2

Trevor Graham @trevorgraham.bsky.social · 10h

We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.

1 10 10

Reposted by Trevor Graham

Dan Landau @landau.bsky.social · 16h

Big, beautiful trees!!

SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.

www.biorxiv.org/content/10.1...

1 8 31

Trevor Graham @trevorgraham.bsky.social · 7d

Great flash talks from Anton Patrikeev (HPV evolution in head and neck cancer) and Florian Gabel (resistance evolution in prostate cancer) both from our @cec-icr.bsky.social @icr.ac.uk #CrickCancerConf

1 8

Reposted by Trevor Graham

Arnau Sebé-Pedrós @arnausebe.bsky.social · 20d

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

2 110 220

Trevor Graham @trevorgraham.bsky.social · Sep 13

thanks Vijay!

1

Trevor Graham @trevorgraham.bsky.social · Sep 12

Here's @calumgabbutt.bsky.social's nice thread on our #EVOFLUx paper in @nature.com that uses fluctuating methylation to track cancer evolution

Calum Gabbutt @calumgabbutt.bsky.social · Sep 10

Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7)
rdcu.be/eFrrc

Fluctuating DNA methylation tracks cancer evolution at clinical scale

Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

rdcu.be

1 11

Trevor Graham @trevorgraham.bsky.social · Sep 10

Thanks Christian!

1

Trevor Graham @trevorgraham.bsky.social · Sep 10

A nice news and views about the paper too: www.nature.com/articles/d41...

Thank you Pavlo Lutsik @kuleuvenuniversity.bsky.social & Veselin Manojlovic, George Vassiliou @cruk-ci.bsky.social

Epigenetic clues from cancer’s past foretell its future

An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.

www.nature.com

1 3

Trevor Graham @trevorgraham.bsky.social · Sep 10

I'm really excited about this work: EVOFLUx tech means we can measure cancer evo at massive scale, even reusing old data. Truly joyful collaboration with brilliant @calumgabbutt.bsky.social Inaki Martin & Marti Duran @idibaps.bsky.social @imperialcollegeldn.bsky.social @qmbci.bsky.social @icr.ac.uk

1 4

Trevor Graham @trevorgraham.bsky.social · Sep 10

With the wonderful Inaki Martin-Subero & Marti Duran @idibaps.bsky.social we applied the method (called EVOFLUx) to meth data from ~2000 lymphoid cancers, inferring cancer age, initial growth rate & other evo dynamics. This evolutionary history strongly predicted clinical outcome, especially in CLL.

1 2

Trevor Graham @trevorgraham.bsky.social · Sep 10

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

www.nature.com

7 39 92

Trevor Graham @trevorgraham.bsky.social · Jul 29

This looks very cool... implementing mathematical models of cell and tissue biology from plain-text human readable statements. I want to have a play with it! Congratulations Paul @mathcancer.bsky.social and team

Paul Macklin @mathcancer.bsky.social · Jul 28

Really excited to share our new @cellpress.bsky.social Cell paper with @fertiglab.bsky.social and colleagues. 1/n

www.cell.com/cell/fulltex...

@jktgfoundation.bsky.social @itcrtraining.bsky.social @smbmathbiology.bsky.social #mathbio #mathonco @mathonco.bsky.social @deniswirtz.bsky.social

Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories

We developed a plain text modeling language—a cell behavior hypothesis grammar—to easily build virtual cell models and connect them to data, helping scientists to unlock the hidden dynamics of tissues...

www.cell.com

1 1 9

Trevor Graham @trevorgraham.bsky.social · Jul 17

Congrats Kit! @yosoykit.bsky.social Extremely worthy recipient of the Leah Edelstein-Kehset prize #SMB2025: she is leading the way modelling disease progression to improve early detection and prevention of #cancer

smb.org/SMB-Awards

1 4 19

Trevor Graham @trevorgraham.bsky.social · Jul 17

Goldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature

A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disru...

www.nature.com

12 31

Reposted by Trevor Graham

Trevor Graham @trevorgraham.bsky.social · Jul 15

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

Search jobs for external candidates | Jobs | Imperial College London

www.imperial.ac.uk

1 13 17

Trevor Graham @trevorgraham.bsky.social · Jul 15

Schmidt Fellows: if you're a #compbio #AI postdoc, feel free to drop me a line to discuss ideas and I can help you find host labs in the @icr.ac.uk

Postdocs in the USA who'd like to return to Europe to set up their own thing... these could be for you?

www.imperial.ac.uk/jobs/search-...

Search jobs for external candidates | Jobs | Imperial College London

www.imperial.ac.uk

2

Trevor Graham @trevorgraham.bsky.social · Jul 15

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

Search jobs for external candidates | Jobs | Imperial College London

www.imperial.ac.uk

1 13 17

Trevor Graham @trevorgraham.bsky.social · Jul 10

New review from @chloecolson.bsky.social on cancer evolution & plasticity from a mathematical modelling lens: www.sciencedirect.com/science/arti...

Chloe provides a framework to think about plasticity & evolution, & explains how maths models can reveal cell dynamics that we can't directly observe.

Mathematical modelling of cancer cell evolution and plasticity

In this review, we argue that mathematical modelling is an essential tool for understanding cancer cell evolution and phenotypic plasticity. We show t…

www.sciencedirect.com

7 24

Trevor Graham @trevorgraham.bsky.social · Jul 8

Enjoyed this @natrevcancer.nature.com article on comparative oncology - how we can learn from other species 🐘🐋🦜🐍 about ways to prevent (& possibly treat) cancer. Both a review and a call to action for the research community. www.nature.com/articles/s41... @atjcagan.bsky.social @cmaley.bsky.social

Advancing cancer research via comparative oncology - Nature Reviews Cancer

Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms un...

www.nature.com

8 23

Trevor Graham @trevorgraham.bsky.social · Jul 4

Congratulations @vinaya-gunasri.bsky.social. Fantastic achievement, look forward to seeing your lab grow.

Vinaya Gunasri @vinaya-gunasri.bsky.social · Jul 4

🏆 Honoured to receive the 2025 Inaugural BACR Early Career Award!
Grateful to @thebacr.bsky.social and all who’ve supported me — esp. @trevorgraham.bsky.social, @eszterlakatos.bsky.social & @cancerresearchuk.org 💙
Reflections→ www.bacr.org.uk/news/2025-in...
#CancerResearch #EarlyCareer #ScienceWins

1 2

Trevor Graham @trevorgraham.bsky.social · Jul 3

Closing keynote from the fabulous @atjcagan.bsky.social on "The impossibility of whales" discussing somatic mutagenesis across species. Brilliantly delivered and exceptionally illustrated talk, as anyone who knows Alex's work would expect! #EBECancer25
@eventswcs.bsky.social

1 3 4

Trevor Graham @trevorgraham.bsky.social · Jul 2

Great press write up of @beckilee.bsky.social's DyNAMIC clinical trial, testing adaptive targeted therapy for melanoma with ctDNA guided decision making. The hope is that ctDNA guided treatment cessation and restart (potentially less drug, less often) will improve outcomes for patients.

Becki Lee @beckilee.bsky.social · Jul 2

Mathematical models and ctdna have reached the clinic - the ultimate personalised trial testing adaptive targeted therapy highlighted in the news today!
#EBEcancer25

www.express.co.uk/life-style/h...

UK cancer breakthrough as simple blood test could help pinpoint treatment

EXCLUSIVE: Skin cancers can be among the most aggressive forms of the disease so using drugs to shrink them must be used with precision.

www.express.co.uk

5