Great news!!!

Is it close to PhD level? 😁

GPT-5:

You’d like a sentence pair where the English sentence has at least 6 words, and the German translation is about twice as long in characters:

English (44 characters, 7 words):
She always takes the train to work.

German (90 characters, 9 words):
Sie fährt immer mit der Eisenbahn zur Arbeit.

The field is huge, I just meant how commonly this term has been used as of now... Tbh, I would really mind seeing back this term more often, as long as it is well defined somewhere in the manuscripts.

I just checked if people use the term epiproteomics, and actually I see 11 publications in PubMed with this term. Global changes in the PTMs of the proteome could be called epiproteomics, I guess...

I tried Mongozo buckwheat white beer and it was quite good :)

Targeting protein disorder: the next hurdle in drug discovery www.nature.com/articles/s41...
rdcu.be/eqaY3

Intrinsically disordered proteins are often dysregulated in disease, but have been considered ‘undruggable’. This new Review discusses approaches that could tackle this barrier

#NatureReviews #DrugDiscovery #ProteinDisorder #ProteinEnsembles #TranscriptionFactors #BiomolecularCondensates #LLPS #imods #IDP #IDPs #HTS #HCS #Biophysics #StructuralBiology #Bioinformatics #ComputationalModeling #MolecularDynamics @viblifesciences.bsky.social @vubrussel.bsky.social

🚨 New Review in @natrevdrugdiscov.nature.com!

We reviewed how to #drug intrinsically disordered proteins ( #IDPs) 🧬

Among many others, we touch upon:
🧪 IDP modulators (i-mods) in clinical trials;
🔬 Exp.+comp. synergy;
🚀 A path forward to target IDPs

📖 Read more: doi.org/10.1038/s41573-025-01220-6

This is very cool! 🤩

I think it is around 45 minutes for lecture, then I usually change the topic or have interactions (or have a short break) to freshen up, and then use the second part of the 2h slot of teaching for a slightly or totally different topic. But anyway I prefer the maximally interactive format 🙂

Basically describes something like AF2-3 with either atom coordinate prediction or torsion angle prediction for modeling a protein structure or protein-ligand complex.

Wow, this surprised me!

It's back for us!

Nothing from the #NIH domain seems to be accessible to me (from Belgium)

I cannot access #PubMed or #PubChem. Are they down???

The author rather used a Proton Mail address for contact info than the EPFL email address. It tells me something... 😏

In #China, the #publication #retractation rate is ~10x higher than 5 years ago. 😮
Some of the reasons why this is happening are well-understood.

📰 Source: journals.plos.org/plosone/arti...

Our latest #C9orf72 ALS paper is out demonstrating biomolecular #condensation of #G3BP1 driven by R-DPRs:
📰 C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1 🔬
www.pnas.org/doi/10.1073/...

#neurodegeneration #MND #ALS #endALS #FTD #LLPS

You can also find the shorter forms of these in AFDB:
alphafold.com/entry/H9T8G6
alphafold.com/entry/A0A3C0...
and I'm wondering if the one below is a different evolutionary path where the beta-helix "spiky" part is followed by more than a dozen MBG adhesin(?) domains:
alphafold.com/entry/Q9HVG6

Hello #Bluesky 👋
After the golden age of #Twitter, I'm noticing that the scientific community has been moving here, so I'll also post things here besides my #X profile: x.com/LazTamas
💬 I'll follow discussions on #proteinengineering #AI #TMBs #OMPs #IDPs #LLPS #condensates #neurodegeneration #ALS