Author | Lightnews

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · 7d

Having a psychiatric condition after an #MS diagnosis is associated with greater disability over time.

📣 New study investigated whether psychiatric conditions (e.g. depression, anxiety) before MS onset affects future disability.

It’s ⬇️ tremlettsmsresearchexplained.wordpress.com/2025/10/27/p...

Psychiatric Morbidity During the Multiple Sclerosis Prodrome is Associated with Future Disability Explained

by Sharon Roman[i] Mounting evidence supports an early phase of multiple sclerosis (MS) known as a prodrome. A prodromal phase is an early phase of nonspecific signs and symptoms that occur before …

tremlettsmsresearchexplained.wordpress.com

1 4

Sharon Roman (n of 1) @sroman.bsky.social · 7d

Having a psychiatric condition after an #MS diagnosis is associated with greater disability over time.

📣 New study investigated whether psychiatric conditions (e.g. depression, anxiety) before MS onset affects future disability.

It’s ⬇️ tremlettsmsresearchexplained.wordpress.com/2025/10/27/p...

Psychiatric Morbidity During the Multiple Sclerosis Prodrome is Associated with Future Disability Explained

by Sharon Roman[i] Mounting evidence supports an early phase of multiple sclerosis (MS) known as a prodrome. A prodromal phase is an early phase of nonspecific signs and symptoms that occur before …

tremlettsmsresearchexplained.wordpress.com

1 4

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · 13d

What are the long-term health effects of interferon-beta use in people with #MS?

💥New population-based drug safety study with up to >20 years of follow-up published.

It’s explained: tremlettsmsresearchexplained.wordpress.com/2025/10/15/r...

Risk of cardiovascular and autoimmune disease in people with multiple sclerosis on long-term interferon-β therapy explained

by Sharon Roman[i] Interferon-b (Beta) is involved in the body’s response to infection and acts as a crucial part of the immune system. Research has previously suggested that too much interferon-be…

tremlettsmsresearchexplained.wordpress.com

1

Sharon Roman (n of 1) @sroman.bsky.social · 13d

What are the long-term health effects of interferon-beta use in people with #MS?

💥New population-based drug safety study with up to >20 years of follow-up published.

It’s explained: tremlettsmsresearchexplained.wordpress.com/2025/10/15/r...

Risk of cardiovascular and autoimmune disease in people with multiple sclerosis on long-term interferon-β therapy explained

by Sharon Roman[i] Interferon-b (Beta) is involved in the body’s response to infection and acts as a crucial part of the immune system. Research has previously suggested that too much interferon-be…

tremlettsmsresearchexplained.wordpress.com

1

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · 18d

Should people radiologically isolated syndrome (RIS) be treated with an #MS therapy?

📣 New study found treatment associated with ⬇️ or delayed risk of developing MS, but with ⬆️ adverse effects.

It’s explained tremlettsmsresearchexplained.wordpress.com/2025/10/16/d...

Disease modifying treatment of radiologically isolated syndrome: a systematic review of the use, efficacy, effectiveness, and safety explained

by Sharon Roman[i] Radiologically isolated syndrome (RIS), first formally defined in 2009, is a distinct condition in the range of central nervous system demyelinating diseases such as multiple scl…

tremlettsmsresearchexplained.wordpress.com

1

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · 19d

💥Study of 19k people (>20 years) with #MS taking interferon-beta and risk of cardiovascular & autoimmune disease found a small ⬆️ risk of cardiovascular disease with longer interferon-beta use.

The benefits are still clear.

It’s explained tremlettsmsresearchexplained.wordpress.com/2025/10/15/r...

Risk of cardiovascular and autoimmune disease in people with multiple sclerosis on long-term interferon-β therapy explained

by Sharon Roman[i] Interferon-b (Beta) is involved in the body’s response to infection and acts as a crucial part of the immune system. Research has previously suggested that too much interferon-be…

tremlettsmsresearchexplained.wordpress.com

1

Sharon Roman (n of 1) @sroman.bsky.social · 18d

Should people radiologically isolated syndrome (RIS) be treated with an #MS therapy?

📣 New study found treatment associated with ⬇️ or delayed risk of developing MS, but with ⬆️ adverse effects.

It’s explained tremlettsmsresearchexplained.wordpress.com/2025/10/16/d...

Disease modifying treatment of radiologically isolated syndrome: a systematic review of the use, efficacy, effectiveness, and safety explained

by Sharon Roman[i] Radiologically isolated syndrome (RIS), first formally defined in 2009, is a distinct condition in the range of central nervous system demyelinating diseases such as multiple scl…

tremlettsmsresearchexplained.wordpress.com

1

Sharon Roman (n of 1) @sroman.bsky.social · 19d

💥Study of 19k people (>20 years) with #MS taking interferon-beta and risk of cardiovascular & autoimmune disease found a small ⬆️ risk of cardiovascular disease with longer interferon-beta use.

The benefits are still clear.

It’s explained tremlettsmsresearchexplained.wordpress.com/2025/10/15/r...

Risk of cardiovascular and autoimmune disease in people with multiple sclerosis on long-term interferon-β therapy explained

by Sharon Roman[i] Interferon-b (Beta) is involved in the body’s response to infection and acts as a crucial part of the immune system. Research has previously suggested that too much interferon-be…

tremlettsmsresearchexplained.wordpress.com

1

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · Sep 30

The ED is often used for kids with severe/unexplained symptoms. Neurologic emergencies make up 1/3 of severe ED cases in kids.

Patterns (rates & reasons) of ED use may reveal potential early warning signs before paediatric-onset #MS.

⬇️
tremlettsmsresearchexplained.wordpress.com/2025/09/17/u...

Use of the Emergency Department Before Pediatric-Onset Multiple Sclerosis Explained

by Sharon Roman[i] Paediatric-onset MS (PoMS), defined as MS onset under aged 18, makes up approximately 3–10% of all MS cases. PoMS is associated with higher relapse rates, and higher lesion load …

tremlettsmsresearchexplained.wordpress.com

1

Sharon Roman (n of 1) @sroman.bsky.social · Sep 30

The ED is often used for kids with severe/unexplained symptoms. Neurologic emergencies make up 1/3 of severe ED cases in kids.

Patterns (rates & reasons) of ED use may reveal potential early warning signs before paediatric-onset #MS.

⬇️
tremlettsmsresearchexplained.wordpress.com/2025/09/17/u...

Use of the Emergency Department Before Pediatric-Onset Multiple Sclerosis Explained

by Sharon Roman[i] Paediatric-onset MS (PoMS), defined as MS onset under aged 18, makes up approximately 3–10% of all MS cases. PoMS is associated with higher relapse rates, and higher lesion load …

tremlettsmsresearchexplained.wordpress.com

1

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · Sep 17

New study examined emergency dept. use by rates & reasons in the years before paediatric-onset #MS.

Higher rates of ED visits began 12 years before & rose for 7 reasons. One year before onset, rates significantly ⬆️ for 5 reasons.

It’s ⬇️
tremlettsmsresearchexplained.wordpress.com/2025/09/17/u...

Use of the Emergency Department Before Pediatric-Onset Multiple Sclerosis Explained

by Sharon Roman[i] Paediatric-onset MS (PoMS), defined as MS onset under aged 18, makes up approximately 3–10% of all MS cases. PoMS is associated with higher relapse rates, and higher lesion load …

tremlettsmsresearchexplained.wordpress.com

1

Sharon Roman (n of 1) @sroman.bsky.social · Sep 17

New study examined emergency dept. use by rates & reasons in the years before paediatric-onset #MS.

Higher rates of ED visits began 12 years before & rose for 7 reasons. One year before onset, rates significantly ⬆️ for 5 reasons.

It’s ⬇️
tremlettsmsresearchexplained.wordpress.com/2025/09/17/u...

Use of the Emergency Department Before Pediatric-Onset Multiple Sclerosis Explained

by Sharon Roman[i] Paediatric-onset MS (PoMS), defined as MS onset under aged 18, makes up approximately 3–10% of all MS cases. PoMS is associated with higher relapse rates, and higher lesion load …

tremlettsmsresearchexplained.wordpress.com

1

Sharon Roman (n of 1) @sroman.bsky.social · Sep 12

Okay, all. What if I told you #MS begins far earlier than previously thought? ⬇️

Sharon Roman (n of 1) @sroman.bsky.social · Aug 8

#MS may begin far earlier than previously thought.

Sharon Roman (n of 1) @sroman.bsky.social · Aug 5

💥 study examining healthcare use 25 years before neurologist-determined #MS symptom onset adds new insight to the early phase (prodrome) of MS.

Signs emerge 15 years before diagnosis challenging assumptions of when MS begins.

Explained⬇️

tremlettsmsresearchexplained.wordpress.com/2025/08/05/h...

Sharon Roman (n of 1) @sroman.bsky.social · Sep 11

#ICYMI children with #MS face additional barriers to treatment.

Sharon Roman (n of 1) @sroman.bsky.social · Aug 27

#MS is the same disease in children & adults. Studies show effectiveness of MS therapies in long-term outcomes, but approved therapies for children are scarce.

What are the barriers to treatment for children with MS?

It's explained⬇️
tremlettsmsresearchexplained.wordpress.com/2025/08/27/a...

Access to therapy for children and adolescents with multiple sclerosis: global considerations in preventing disease progression explained

by Sharon Roman[i] Paediatric-onset multiple sclerosis (PoMS), defined as MS onset under aged 18, makes up approximately 1–5% of all MS cases. Globally, an estimated 30,000 children have MS. PoMS i…

tremlettsmsresearchexplained.wordpress.com

1

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · Aug 27

#MS is the same disease in children & adults. Studies show effectiveness of MS therapies in long-term outcomes, but approved therapies for children are scarce.

What are the barriers to treatment for children with MS?

It's explained⬇️
tremlettsmsresearchexplained.wordpress.com/2025/08/27/a...

Access to therapy for children and adolescents with multiple sclerosis: global considerations in preventing disease progression explained

by Sharon Roman[i] Paediatric-onset multiple sclerosis (PoMS), defined as MS onset under aged 18, makes up approximately 1–5% of all MS cases. Globally, an estimated 30,000 children have MS. PoMS i…

tremlettsmsresearchexplained.wordpress.com

1 1

Sharon Roman (n of 1) @sroman.bsky.social · Aug 27

#MS is the same disease in children & adults. Studies show effectiveness of MS therapies in long-term outcomes, but approved therapies for children are scarce.

What are the barriers to treatment for children with MS?

It's explained⬇️
tremlettsmsresearchexplained.wordpress.com/2025/08/27/a...

Access to therapy for children and adolescents with multiple sclerosis: global considerations in preventing disease progression explained

by Sharon Roman[i] Paediatric-onset multiple sclerosis (PoMS), defined as MS onset under aged 18, makes up approximately 1–5% of all MS cases. Globally, an estimated 30,000 children have MS. PoMS i…

tremlettsmsresearchexplained.wordpress.com

1 1

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · Aug 8

#MS may begin far earlier than previously thought.

Sharon Roman (n of 1) @sroman.bsky.social · Aug 5

💥 study examining healthcare use 25 years before neurologist-determined #MS symptom onset adds new insight to the early phase (prodrome) of MS.

Signs emerge 15 years before diagnosis challenging assumptions of when MS begins.

Explained⬇️

tremlettsmsresearchexplained.wordpress.com/2025/08/05/h...

Healthcare use before multiple sclerosis symptom onset explained

by Sharon Roman[i] Several chronic neurologic disorders have a recognized early phase of disease known as a prodromal phase, enabling early detection and intervention. A prodromal phase is an early…

tremlettsmsresearchexplained.wordpress.com

1

Sharon Roman (n of 1) @sroman.bsky.social · Aug 8

#MS may begin far earlier than previously thought.

Sharon Roman (n of 1) @sroman.bsky.social · Aug 5

💥 study examining healthcare use 25 years before neurologist-determined #MS symptom onset adds new insight to the early phase (prodrome) of MS.

Signs emerge 15 years before diagnosis challenging assumptions of when MS begins.

Explained⬇️

tremlettsmsresearchexplained.wordpress.com/2025/08/05/h...

Healthcare use before multiple sclerosis symptom onset explained

by Sharon Roman[i] Several chronic neurologic disorders have a recognized early phase of disease known as a prodromal phase, enabling early detection and intervention. A prodromal phase is an early…

tremlettsmsresearchexplained.wordpress.com

1

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · Aug 5

💥 study examining healthcare use 25 years before neurologist-determined #MS symptom onset adds new insight to the early phase (prodrome) of MS.

Signs emerge 15 years before diagnosis challenging assumptions of when MS begins.

Explained⬇️

tremlettsmsresearchexplained.wordpress.com/2025/08/05/h...

Healthcare use before multiple sclerosis symptom onset explained

by Sharon Roman[i] Several chronic neurologic disorders have a recognized early phase of disease known as a prodromal phase, enabling early detection and intervention. A prodromal phase is an early…

tremlettsmsresearchexplained.wordpress.com

1

Sharon Roman (n of 1) @sroman.bsky.social · Aug 5

💥 study examining healthcare use 25 years before neurologist-determined #MS symptom onset adds new insight to the early phase (prodrome) of MS.

Signs emerge 15 years before diagnosis challenging assumptions of when MS begins.

Explained⬇️

tremlettsmsresearchexplained.wordpress.com/2025/08/05/h...

Healthcare use before multiple sclerosis symptom onset explained

by Sharon Roman[i] Several chronic neurologic disorders have a recognized early phase of disease known as a prodromal phase, enabling early detection and intervention. A prodromal phase is an early…

tremlettsmsresearchexplained.wordpress.com

1

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · Jul 24

Happy third anniversary 🎉 to …ettsmsresearchexplained.wordpress.com!

Three years of explaining real-time #MS research in plain language. We believe research findings should be explained simply, empowering those who stand to benefit with knowledge to help guide decisions in care.

Join us!

1

Sharon Roman (n of 1) @sroman.bsky.social · Jul 24

Happy third anniversary 🎉 to …ettsmsresearchexplained.wordpress.com!

Three years of explaining real-time #MS research in plain language. We believe research findings should be explained simply, empowering those who stand to benefit with knowledge to help guide decisions in care.

Join us!

1

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · Mar 1

We're dedicated to making #MS research easier to understand. We believe research findings should be explained simply, empowering those who stand to benefit from it with knowledge to help guide decisions in care.

tremlettsmsresearchexplained.wordpress.com

✔️real-time study results in plain language

Tremlett's MS Research Explained

Prof. Tremlett's multiple sclerosis (MS) research in plain language

tremlettsmsresearchexplained.wordpress.com

1 1 2

Reposted by Sharon Roman (n of 1)

Sharon Roman (n of 1) @sroman.bsky.social · Jul 3

Chronic conditions may start years before classical symptoms occur. Often, signs & symptoms not specific to the disease occur in this early phase (prodrome).

💥Study describes healthcare use 2-3 decades before #MS onset.

It’s explained ⬇️

tremlettsmsresearchexplained.wordpress.com/2025/06/26/p...

Phenotyping Healthcare Use 2–3 Decades Before the First Multiple Sclerosis Demyelinating Event Explained

by Sharon Roman[i] Chronic conditions may start years before classical symptoms appear. Often, signs and symptoms not specific to the condition occur before classical symptoms in what is known as a…

tremlettsmsresearchexplained.wordpress.com

2 3

Sharon Roman (n of 1) @sroman.bsky.social · Jul 3

Chronic conditions may start years before classical symptoms occur. Often, signs & symptoms not specific to the disease occur in this early phase (prodrome).

💥Study describes healthcare use 2-3 decades before #MS onset.

It’s explained ⬇️

tremlettsmsresearchexplained.wordpress.com/2025/06/26/p...

Phenotyping Healthcare Use 2–3 Decades Before the First Multiple Sclerosis Demyelinating Event Explained

by Sharon Roman[i] Chronic conditions may start years before classical symptoms appear. Often, signs and symptoms not specific to the condition occur before classical symptoms in what is known as a…

tremlettsmsresearchexplained.wordpress.com

2 3