Interestingly, we have collaboration with #Barntumörbanken where we collect these paired primary and relapse samples to study the tumor evolution and also focus on understanding best treatment strategies for these patient #ISRVT25

Btw, I am a second year PhD student working on DMG. We are mostly using patient biopsies and trying to understand different treatment options for these patients #ISRVT25

They are mostly occurring in pre-school children growing in the thalamus, pons or the brain stem. #ISRVT25

Diffuse Midline Glioma is one of the most aggressive childhood brain tumors, with very limited treatment options.
They are known to have signature mutations in histone 3 variants. Additional mutations also include PDGFRA, TP53, ACVR1 and PI3K mutations #ISRVT25

And additionally is also quite nice because this was one can also setup high throughput drug screening with these cultures. They are more transactional than 2D cultures since they have a microenvironment.

This is the reason why tumoroid or organoid cultures have become so attractive in these kind of studies in the last few years

One of the reasons why it is important to have the 3D microenvironment around these cells to get a better overview on how they are interacting or establishing themselves or even surviving (3/5)

Most of these tumor cultures tend to die or loose their properties when cultured in 2D.
One of the most common examples being Sonic-Hedgehog Medulloblastoma
#ISRVT25

Some interesting information when it comes to working with patient biopsies from brain.
#ISRVT25

Did you know co-culturing iPSC-derived brain organoids with microglia can help the organoids mature faster? This was a great, crisp paper I came across.
#ISRVT25
www.nature.com/articles/s41...

Greatly honoured to be selected for an oral presentation at Berlin Brain Tumor Meeting #BTM2024

Big thanks to organisers for selecting our abstract for an oral talk and also to the audience for the great comments and questions
#ISRVT25

Quite an interesting article on targeting PDGFRA altered High-Grade Glioma
#ISRVT25
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib: Cancer Cell www.cell.com/cancer-cell/...