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Sreejith Parameswaran @sreejithdr.bsky.social · 18d

Gandhi Jayanthi Morning 12K 🏃🏽‍♂️
With humidity above 80%, I was drenched in sweat as if I took a shower during the run! 🥵

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Sreejith Parameswaran @sreejithdr.bsky.social · Sep 14

CKDu as a Tubulointerstitial Disease - a narrative review I wrote with Dr Magdalena Maduro :
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Thank You @pranavgarimella for asking us to contribute for @akdhjournal

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Sreejith Parameswaran @sreejithdr.bsky.social · Sep 12

Agree with you on the political angle - if someone moved to BlueSky to stay away from all the political drama, they were fooled. Only difference is that it is one sided on BlueSky.
I wish people kept both accounts & discussed science & Nephrology in BlueSky & politics in Twitter!

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Sreejith Parameswaran @sreejithdr.bsky.social · Aug 31

Sunday Morning 12K 🏃🏽‍♂️
The biggest threat to the 'streak' are the medical conferences happening almost every weekend! 😅

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Sreejith Parameswaran @sreejithdr.bsky.social · Aug 30

If this is not a calamity, what is?
172,000 people died in 2023 on Indian roads, translating into 1317 accidents & 474 deaths every day or 55 accidents and 20 deaths every hour!! 🫢
Most of them in young & productive age.
This is worse than dropping a nuclear bomb!
#RoadSafety

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Sreejith Parameswaran @sreejithdr.bsky.social · Aug 24

Turns out we ourselves (how we like, share) are to blame for SoMe toxicity and not algorithms! 😐
www.newscientist.com/article/2492...

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Sreejith Parameswaran @sreejithdr.bsky.social · Aug 24

Sunday Morning 12K 🏃🏽‍♂️

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Sreejith Parameswaran @sreejithdr.bsky.social · Aug 10

Sunday Morning 12K 🏃🏽‍♂️
(showing 13K because of tracking error).
#MakingProgress

Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

That is a wrap!
Thank you for staying with me on this thread!
#AKI #CCNA 2.0
18/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

While biomarkers have the potential to enhance our ability to care for people with AKI, we need more work in this area.
Even when we have useful biomarkers, they are expected to refine our abilities and not to replace Creatinine & U.O.
#AKI #CCNA 2.0
17/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

What is the future of AKI Biomarkers?
#AKI #CCNA 2.0
16/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

A novel point-of-care (POC) uNGAL Dipstick was developed at the Columbia University by Dr Jonathan Barasch and was tested @JipmerNephro for predicting AKI risk in patients seeking treatment at the emergency services
pubmed.ncbi.nlm.nih.gov/40630276/
#AKI #CCNA 2.0
15/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

Despite all these, there are many challenges & limitations when it comes to applying AKI biomarkers in routine clinical practice
pubmed.ncbi.nlm.nih.gov/33021646/
#AKI #CCNA 2.0
14/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

04 - Progression & Recovery
pubmed.ncbi.nlm.nih.gov/33021646/
#AKI #CCNA 2.0
13/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

The proposed new diagnosis and staging system for AKI incorporating Biomarkers
pubmed.ncbi.nlm.nih.gov/33021646/
#AKI #CCNA 2.0
12/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

03 - Diagnosis, Aetiology & Management
#AKI #CCNA 2.0
11/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

The NephroCheck(R) Test is validated & FDA approved
#AKI #CCNA 2.0
10/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

02 - AKI Prediction & Prevention
pubmed.ncbi.nlm.nih.gov/33021646/
#AKI #CCNA 2.0
9/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

The 'Kidney Health Assessment' framework
pubmed.ncbi.nlm.nih.gov/33021646/
#AKI #CCNA 2.0
8/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

Let us see what their current clinical applications are.
Please refer to the ADQI consensus statement too: pubmed.ncbi.nlm.nih.gov/33021646/
01 - AKI Risk Assessment
#AKI #CCNA 2.0
7/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

AKI Biomarkers can be categorised broadly into three categories:
1️⃣Function Markers
2️⃣Stress Markers
3️⃣Damage Markers
#AKI #CCNA 2.0
6/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

It is not that there are no biomarkers to assess kidney injury & damage. Many were studied extensively and newer ones are being identified
#AKI #CCNA 2.0
5/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

Urine output is also not exactly reliable as a marker of kidney function.
#AKI #CCNA 2.0
4/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

The limitations of Serum Creatinine as a marker of kidney function are well known.
#AKI #CCNA 2.0
3/18

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Sreejith Parameswaran @sreejithdr.bsky.social · Jul 26

Biomarkers are everywhere in clinical medicine & are well entrenched in Cardiology, Oncology, etc. However, in Nephrology, Bioamarkers are still not 'mainstream'.
#AKI #CCNA 2.0
2/18

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