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Reposted by Dr. Shivani Ruparel

The Journal of Pain @thejournalofpain.bsky.social · Jun 23

Original: Drs. Merlo, @shivanibr.bsky.social et al. discovered that TrkBT1, not full-length TrkB, is the main isoform in trigeminal nociceptors. It modulates BDNF-induced sensitization and survival, redefining TrkBT1 as an active player in pain signaling

Full: www.jpain.org/article/S152...

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Dr. Shivani Ruparel @shivanibr.bsky.social · May 26

My latest travel Post on Sedona AZ: A Relaxing getaway for all age groups. #travel #sedona #arizona trips #redrocks #americandesert mytripscripts.com/2025/05/26/c...

Cool Trails & Red Rock Tales: A December Getaway to Sedona

There are some places that wrap you in a warm hug the moment you arrive, and Sedona in December is one of them. Nestled amidst towering red rock formations, this Arizona gem offers a tranquil retre…

mytripscripts.com

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Dr. Shivani Ruparel @shivanibr.bsky.social · May 21

What we do in the newly established Center of Pain Therapeutics and Addiction Research (CPTAR) in School of Dentistry @uthealthsa.bsky.social #painresearch magazines.uthscsa.edu/schools/2025...

Looking beyond opioids - Magazines of the Schools at UT Health San Antonio

A revolution in pain exploration has been launched with the school’s new Center for Pain Therapeutics and Addiction Research. Interdisciplinary collaboration is helping investigators study non-opioid ...

magazines.uthscsa.edu

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Dr. Shivani Ruparel @shivanibr.bsky.social · May 21

For early-stage investigators grants.nih.gov/grants/guide...

NOT-OD-25-114: Notice of Short-Term Extension to Early-Stage Investigator (ESI) Eligibility Period

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Short-Term Extension to Early-Stage Investigator (ESI) Eligibility Period NOT-OD-25-114. OD

grants.nih.gov

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Dr. Shivani Ruparel @shivanibr.bsky.social · May 17

Our paper in Journal of Pain challenges old labels: TrkB isnt just an A-LTMR marker. Its truncated isoform is expressed and functional in trigeminal nociceptors, opening new avenues for studying the receptor in pathological pain #painresearch www.sciencedirect.com/science/arti...

Truncated TrkB: The predominant TrkB isoform in nociceptors

Truncated TrkB (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral…

www.sciencedirect.com

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Dr. Shivani Ruparel @shivanibr.bsky.social · May 14

Congratulations to my student Priya Narayanan for an excellent performance on defending her MS thesis focused on the molecular mechanisms underlying oral mucositis @uthealthsa.bsky.social. I am a proud mentor today. #teachingisrewarding #graduateeducation

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Dr. Shivani Ruparel @shivanibr.bsky.social · May 3

New paper out from my lab and Dr. Akopian's lab. First of its kind to characterize mechanically-gated trigeminal neurons in non-rodent higher order species. #painresearch #nonrodentmodels www.eneuro.org/content/earl...

Investigating Mechanically Activated Currents from Trigeminal Neurons of Non-Human Primates

Pain sensation often involves mechanical modalities. Mechanically activated (MA) ion channels on sensory neurons underly responsiveness to mechanical stimuli. MA current properties have mainly been de...

www.eneuro.org

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Dr. Shivani Ruparel @shivanibr.bsky.social · Apr 1

UT Health San Antonio ranks among the top 50 medical schools in the nation for National Institutes of Health research funding.
news.uthscsa.edu/ut-health-sa...

UT Health San Antonio’s accelerated rise: Advancing innovation, research and national impact - UT Health San Antonio

UT Health San Antonio’s Accelerated Rise: Advancing Innovation, Research and National Impact

news.uthscsa.edu

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Reposted by Dr. Shivani Ruparel

Dr. Rajesh Khanna of the KhannaLabUF @khannalabuf.bsky.social · Apr 1

mbi.ufl.edu/2025/04/01/r...

Researchers present latest advances in developing nonopioid pain relievers » McKnight Brain Institute » University of Florida

UF Center for Advanced Pain Therapeutics and Research (CAPToR) hosts inaugural symposium.

mbi.ufl.edu

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Dr. Shivani Ruparel @shivanibr.bsky.social · Apr 1

Had a blast speaking and catching up w/ Nicole Scheff, @flybottleescape.bsky.social @robgereau.bsky.social @laurenslosky.bsky.social et al at the Center for Adv PainTher and Res (CAPToR) @ufresearch.bsky.social.Thank you @khannalabuf.bsky.social and @maykhanna.bsky.social for hosting us.

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Dr. Shivani Ruparel @shivanibr.bsky.social · Mar 29

www.sciencealert.com/oral-cancer-...

Oral Cancer Cases Are on The Rise, And Sugary Drinks Could Be to Blame

It may not just be tooth decay you need to worry about when it comes to sugary drinks: new research suggests that these sweetened beverages might also be raising the risk of oral cancer.

www.sciencealert.com

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Reposted by Dr. Shivani Ruparel

Michelle Monje @michellemonje.bsky.social · Mar 21

#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler.
www.nature.com/articles/s41...

Cancer research needs neuroscience and neuroscientists - Nature Neuroscience

The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors gro...

www.nature.com

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Dr. Shivani Ruparel @shivanibr.bsky.social · Feb 20

Yet another reason to be proud of @uthealthsa.bsky.social news.uthscsa.edu/ut-health-sa...

UT Health San Antonio earns top Carnegie classification for research, doctorate awards - UT Health San Antonio

The University of Texas Health Science Center at San Antonio earned a Research 1 (R1) designation from the American Council on Education and the Carnegie Foundation for the Advancement of Teaching in ...

news.uthscsa.edu

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Dr. Shivani Ruparel @shivanibr.bsky.social · Feb 2

Interesting article "suggesting a need to recalibrate recruitment expectations. Even moderately above-average individuals on these key dimensions may merit greater recognition due to their scarcity".
www.sciencedirect.com/science/arti...

The number of exceptional people: Fewer than 85 per 1 million across key traits

Cognitive biases can lead to overestimating the expected prevalence of exceptional multi-talented candidates, leading to potential dissatisfaction in …

www.sciencedirect.com

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Reposted by Dr. Shivani Ruparel

UoG Spinal Cord Group @spinalcordgroup.bsky.social · Jan 17

Anyone interested in a PhD in pain research, we have a fully-funded position available in the Weir lab.
www.findaphd.com/phds/project...

Human sensory neuron and macrophage co-culture; developing a model to test agents capable of disrupting painful neuroimmune signalling at University of Glasgow on FindAPhD.com

PhD Project - Human sensory neuron and macrophage co-culture; developing a model to test agents capable of disrupting painful neuroimmune signalling at University of Glasgow, listed on FindAPhD.com

www.findaphd.com

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Reposted by Dr. Shivani Ruparel

Anne-Marie Malfait @jointsintheworld.bsky.social · Jan 15

www.cell.com/cell-genomic...

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

Kramer et al. analyzed gene expression, chromatin accessibility, and 3D chromatin structure in primary human chondrocytes in both normal and OA-like conditions. They mapped eQTLs, performed colocaliza...

www.cell.com

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Reposted by Dr. Shivani Ruparel

Ted Price @tedpricethepainguy.bsky.social · Jan 14

@dereklowe.bsky.social on the evolving suzetrigine and acute and chronic pain story: www.science.org/content/blog... Certainly going to be some interesting times ahead in this area. I agree with him, I think the patient experience in the real world is going to be a huge determining factor...

The Pain Comes With the Territory

www.science.org

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Reposted by Dr. Shivani Ruparel

Dr. Rajesh Khanna of the KhannaLabUF @khannalabuf.bsky.social · Jan 7

Hope springs anew in 2025! 🌸 Here's to a year of breakthroughs in pain relief and brighter, pain-free days ahead for chronic pain patients. #PainRelief

NaV1.8 inhibitor poised to provide opioid-free pain relief www.nature.com/articles/d41...

NaV1.8 inhibitor poised to provide opioid-free pain relief

Vertex’s first-in-class suzetrigine could soon usher in a new class of analgesic.

www.nature.com

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Dr. Shivani Ruparel @shivanibr.bsky.social · Jan 1

Wishing everyone and your families a very safe, healthy and an uneventful 2025! May the magic continue in all your lives😍

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Dr. Shivani Ruparel @shivanibr.bsky.social · Dec 30

My uncle in his retirement graduated from flying school, bought a plane and then built it, to tour around the world. And now I get to ride in it for free. I feel so royal 😬

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Reposted by Dr. Shivani Ruparel

Anne-Marie Malfait @jointsintheworld.bsky.social · Dec 28

arthritis-research.biomedcentral.com/articles/10.... on the role of macrophages in experimental OA pain

Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage - Arthritis Research & Therapy

Background Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions report...

arthritis-research.biomedcentral.com

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Reposted by Dr. Shivani Ruparel

Ted Price @tedpricethepainguy.bsky.social · Dec 27

BOOM! Great stuff on the truncated TrkB isoform in nociception and nociceptors from @shivanibr.bsky.social's lab #painresearch www.biorxiv.org/content/10.1...

Truncated TrkB: The predominant TrkB Isoform in Nociceptors

Truncated form of the tropomyosin receptor kinase B isoform (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral sens...

www.biorxiv.org

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Reposted by Dr. Shivani Ruparel

Dr. Rajesh Khanna of the KhannaLabUF @khannalabuf.bsky.social · Dec 21

POG, from dried roots of Saposhnikovia divaricata, may help treat #OA by regulating lncRNA XIST & Nav1.7. POG improves cartilage damage, reduces inflammation & chondrocyte apoptosis.

Protective mechanism of Prim-O-glucosylcimifugin in the treatment of o... www.sciencedirect.com/science/arti...

Protective mechanism of Prim-O-glucosylcimifugin in the treatment of osteoarthritis: Based on lncRNA XIST regulation of Nav1.7

LncRNA XIST and Nav1.7 have been identified to be significantly associated with the onset of osteoarthritis. Prim-O-glucosylcimifugin (POG) has antiin…

www.sciencedirect.com

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Reposted by Dr. Shivani Ruparel

Ted Price @tedpricethepainguy.bsky.social · Dec 21

BOOM! Big advance from Zak Campbell's lab (Zak used to be at UTD and moved to U Wisconsin a couple of years ago, big loss for us) on regulation of BDNF translation in nociceptors - www.sciencedirect.com/science/arti...

eEF2K regulates pain through translational control of BDNF

mRNA translation is integral to pain, yet the key regulatory factors and their target mRNAs are unclear. Here, we uncover a mechanism that bridges nox…

www.sciencedirect.com

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