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Chise @sailorrooscout.bsky.social · 10m

Tobias this is STUNNING! 🤩

Chise @sailorrooscout.bsky.social · 12m

Thank you kindly!

Reposted by Chise

Chise @sailorrooscout.bsky.social · 42m

GOOD NEWS! Researchers have developed a cancer vaccine that has shown STUNNING results, PREVENTING up to 88% of MULTIPLE aggressive cancers by harnessing dual-pathway nanoparticles that train the immune system to recognize and destroy tumor cells. In some cases, it COMPLETELY prevented metastasis.

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Reposted by Chise

Chise @sailorrooscout.bsky.social · 2d

happy autumn 🍂

An anthropomorphic striped hyena playing in leaves.

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Chise @sailorrooscout.bsky.social · 12m

My pleasure! I thought it was really neat! ☺️

Chise @sailorrooscout.bsky.social · 15m

You’re so sweet Ruggy! I’m just trying to help where I can and share some developments! ☺️

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Chise @sailorrooscout.bsky.social · 16m

🧡🍂

Chise @sailorrooscout.bsky.social · 16m

Let me take a look for you! I would scroll back to a couple of my threads just in case because I am fairly certain I have written a thread in some? But I’ll take a look for something more recent!

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Chise @sailorrooscout.bsky.social · 17m

👏

Chise @sailorrooscout.bsky.social · 17m

Agreed! ☺️👏

Chise @sailorrooscout.bsky.social · 18m

☺️🤞

Chise @sailorrooscout.bsky.social · 18m

👏

Chise @sailorrooscout.bsky.social · 18m

🎯

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Chise @sailorrooscout.bsky.social · 19m

Thank you! Those look amazing! 🥞

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Chise @sailorrooscout.bsky.social · 19m

These studies focused on these particular cancers but they’re looking to expand to other types! bsky.app/profile/sail...

Chise @sailorrooscout.bsky.social · 37m

Melanoma, pancreatic cancer, and triple-negative breast cancer (TNBC) are each serious clinical challenges due to how common or aggressive they are and how poorly they often respond to treatment. Which is why researchers are determined to develop an effective treatment for all of them.

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Chise @sailorrooscout.bsky.social · 20m

Indeed! ☺️👏

Chise @sailorrooscout.bsky.social · 20m

And all sources are here as well! bsky.app/profile/sail...

Chise @sailorrooscout.bsky.social · 22m

You can read all this and more here:
• www.cell.com/cell-reports...
• www.umass.edu/news/article...
• newatlas.com/disease/dual...
• medicalxpress.com/news/2025-10...
• www.newsweek.com/cancer-vacci...
• www.genengnews.com/topics/cance...
• www.westernmassnews.com/2025/10/10/u...

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Chise @sailorrooscout.bsky.social · 20m

Thank you! The link is here! bsky.app/profile/sail...

Chise @sailorrooscout.bsky.social · 40m

Researchers envision their vaccine being used as both a treatment and a preventive, and as an approach to treating multiple cancer types.
• www.umass.edu/news/article...

The study has been published in Cell Reports Medicine. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️

HIGHLIGHTS
•Lipid NPs carrying STING and TLR4 agonists promote synergistic type I interferons
• NPs drain efficiently to lymph nodes and increase polyfunctional T and B cells
• NPs improve tumor-free outcomes with memory against multiple aggressive tumor models
SUMMARY
We report on the utility of a "super-adjuvant" nanoparticle (NP) system as a modular, customizable platform for next-generation cancer vaccination. Using nanomaterials engineering technology, we aim to harness not only the effective adjuvanticity of whole-pathogen vaccines, but also the safety of subunit vaccines.
Our lipid-based NP platform co-encapsulates agonists of the stimulator of interferon genes (STING) and Toll-like receptor 4 (TLR4) pathways to promote synergistic production of type I interferons and other
proinflammatory cytokines in innate antigen-presenting dendritic cells and macrophages.
Compared to empty NPs and free agonists, dual-adjuvant NPs administered with antigenic peptides or tumor cell lysate promote increased antigen processing and presentation, drain efficiently to nearby lymph nodes, increase polyfunctional tumor-specific T and B cells, and improve tumor-free outcomes upon vaccination and subsequent challenge with multiple aggressive tumor cells.

Graphical Abstract

The vaccine combines two immune-stimulating molecules (adjuvants) in a tiny lipid nanoparticle that enhances both innate and adaptive immune responses. The innate immune system acts as the body’s first line of defense, responding quickly and non-specifically to invaders using cells that release inflammatory signals. The adaptive immune system takes longer to activate but provides a targeted, long-lasting response, training T-cells and B- cells to recognize and remember specific threats. Together, they form a coordinated defense: the innate system alerts and activates the adaptive system, which then delivers precise and durable immunity.

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Chise @sailorrooscout.bsky.social · 22m

You can read all this and more here:
• www.cell.com/cell-reports...
• www.umass.edu/news/article...
• newatlas.com/disease/dual...
• medicalxpress.com/news/2025-10...
• www.newsweek.com/cancer-vacci...
• www.genengnews.com/topics/cance...
• www.westernmassnews.com/2025/10/10/u...

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Chise @sailorrooscout.bsky.social · 23m

genetically engineered immune cells that last longer in patients. Although nanoparticle vaccines could become prophylactic agents for people with extremely high genetic risk, or adjuvant therapy to avoid recurrence after surgery or chemotherapy.

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Chise @sailorrooscout.bsky.social · 23m

genetic predispositions. These two studies suggest complementary advances -one boosting the body's native immune warriors and the other preventing cancer from taking up residence in the first place. Discovering how T-cells have evolved metabolically could lead to more effective immunotherapies and

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Chise @sailorrooscout.bsky.social · 24m

immunized mice DID NOT form metastases when challenged again with the cancer. The nanoparticle system could be used both therapeutically and preventively. Researchers hope to be able to design the technology for people at high risk for specific cancers, for instance, people with family histories or

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Chise @sailorrooscout.bsky.social · 26m

a form developed from tumor lysate -inactive cancer cells from actual tumors- to mimic the complex mixture of proteins in human cancers. The vaccine was shown to protect against a number of different types: 88% of mice from pancreatic cancer, 75% from breast cancer, and 69% from melanoma. The

Figure 4 NP administration with tumor lysate for broad immune responses as a platform approach across multiple models

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Chise @sailorrooscout.bsky.social · 27m

metastasis; NONE of them developed lung tumors, even when cancer cells were infused around the body. Researchers called the phenomenon memory immunity- once the body had learned to identify the cancer, it was still ready to fight back should the disease return. Subsequently, researchers attempted

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Chise @sailorrooscout.bsky.social · 27m

more coordinated response. When mice were immunized with this nanoparticle system and later challenged with melanoma cells, 80% of them stayed cancer-free throughout the course of the 250-day study. The control animals did not survive longer than 35 days. The immunized mice also rejected

Figure 3 Multivalent peptide vaccination with NPs for prevention of tumor formation and long-term survival

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