Lightnews — Scholar-powered news

Rob Klose @robklose.bsky.social · 8h

Congratulations Morgan. Excited to have you as a colleague!

Reposted by Rob Klose

Morgan Jones @04mjone.bsky.social · 16h

I’m really excited to share that I’ve been awarded a Wellcome Trust Career Development Award to start my own research group at Oxford University Biochemistry Department @BiochemOxford 🧬🎉

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Reposted by Rob Klose

Ozren Bogdanovic @obog.bsky.social · Mar 13

new lab preprint 👇

Ana Burgos @anaburgos.bsky.social · Mar 13

Ever wondered how sperm are formed? Spermatogenesis is a microscopic marathon that starts in the testes and ends with fully functional sperm! Our new preprint bitly.cx/jC4Qg takes a deep dive into zebrafish spermatogenesis, mapping out every fascinating step. 🧵👇 1/7

A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formation

Spermatogenesis is the biological process by which male sperm cells (spermatozoa) are produced in the testes. Beyond facilitating the transmission of genetic information, spermatogenesis also provides...

bitly.cx

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Reposted by Rob Klose

Stephan Gruber @gruberlab.bsky.social · 18h

Happy that the final version of our Lamassu work @yli18smc.bsky.social is now out:

www.nature.com/articles/s41...

Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social

Stephan Gruber @gruberlab.bsky.social · Mar 16

Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.

Alt : Structure of the apo Lamassu protein complex. Schematic model of the active LmuA tetramer nuclease (top right). Lamassu icon (top left).

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Reposted by Rob Klose

Syma Khalid @sykhalid.bsky.social · 19h

The new Life and Mind building is pretty swanky. @biology.ox.ac.uk

Just awaiting arrivals of first year undergrads. Let’s see what they make of computational biochemistry

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Reposted by Rob Klose

Dr Radu Zabet @raduzabet.bsky.social · 19h

DNA methylation is one of the most studied epigenetic modification associated with regulation of gene expression. Bisulfite-converted genomic DNA sequencing has been the current gold standard in the field for building genome-wide DNAm maps at base pair resolution.

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Reposted by Rob Klose

Lucas Farnung @lucas.farnunglab.com · 1d

We have added new functionality to include a plot of protein disorder using IUPred scores generated by iupred2a.elte.hu. Generate IUPred scores for your POI and upload the JSON file to generate this plot.

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Reposted by Rob Klose

DNA Topology Lab @dnatopologylab.bsky.social · 4d

As always, bacteria light the path of discovery.

Stephan Gruber @gruberlab.bsky.social · 5d

For the specialists: the motor units adopt a DNA-holding conformation, a proposed key state of the segment capture model

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Reposted by Rob Klose

Gurdon Institute, University of Cambridge @gurdoninstitute.bsky.social · 5d

A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 Oct. Not only did he make a discovery that laid the foundations for stem cell research, he also created one of the best environments for research at the Wellcome/CRUK Gurdon Institute wellcome.org/news/sir-joh...

Sir John Gurdon, 1933-2025 | Wellcome

A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 October. He made a discovery that opened up the field of cloning research, and created one of the best environments for res...

wellcome.org

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Reposted by Rob Klose

Stephan Gruber @gruberlab.bsky.social · 5d

How do SMC complexes load onto DNA to get ready for loop extrusion?

@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️.

Check out the new paper: www.cell.com/molecular-ce...

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Reposted by Rob Klose

The Francis Crick Institute @crick.ac.uk · 5d

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Reposted by Rob Klose

Naomi Moris @nmoris.bsky.social · 5d

The Crick is looking for new junior group leaders! Any postdocs or early career researchers wanting to be our colleagues should apply 👍

The Francis Crick Institute @crick.ac.uk · 5d

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Reposted by Rob Klose

Alexis Barr @alexisbarr.bsky.social · 5d

Many of you know, we lost Béla Novák this year. John Tyson, Francis Barr & I tried to capture his wonderful character & great mind so that those that didn't know him can see what a fantastic person he was.

Thanks to @jcellsci.bsky.social for publishing.

journals.biologists.com/jcs/article/...

Béla Novák (1956–2025) – a legacy of scientific discovery and personal charm

In February 2025, we were shocked and deeply saddened to hear about the death of Béla Novák, Professor in Integrative Systems Biology at the University of Oxford, UK, and a beloved grandfather, father...

journals.biologists.com

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Reposted by Rob Klose

Oded Rechavi @odedrechavi.bsky.social · 5d

That person you meet when you attend a scientific conference and want to quickly get breakfast alone before returning to your room to prepare your presentation

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Reposted by Rob Klose

Aydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · 5d

Our PhD call is open, take a look! (we are not recruiting this round)

Max Planck Institute for Molecular Genetics @molgen.mpg.de · 6d

🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences.
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...

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Rob Klose @robklose.bsky.social · 6d

Thanks Duncan, that’s very kind.

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Reposted by Rob Klose

Maxim Greenberg @maxvcg.bsky.social · 6d

I'm glad that most academic institutions are on Bluesky now, so we can get the press releases I used to love on Twitter that are like "Congratulations to this year's Nobel Prize winner _______, who once used our third-floor bathroom."

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Reposted by Rob Klose

Aleksander Szczurek @aleksszczurek.bsky.social · 6d

If you are a computational biologist come, apply and join Howard & Klose lab in a joint Norwich-Oxford collaboration on chromatin dynamics!

John Innes Centre @johninnescentre.bsky.social · 8d

VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system.

www.jic.ac.uk/vacancies/po...

Closing date - 9 November 2025
Salary - £37,500 - £45,350
Contract - 36 months, full-time

Postdoctoral Researcher (Howard Group) | John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.

www.jic.ac.uk

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Reposted by Rob Klose

Alex de Mendoza @alexdemendoza.bsky.social · 6d

Thrilled to share that the lab has been awarded a @wellcometrust.bsky.social Discovery Award to keep exploring the evolution of 6-methyladenine #6mA in Eukaryotes. We'll open postdoc (3️⃣) and tech (1️⃣) positions to start in 2026, please share with candidates or reach out if you’d like to join us.

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Reposted by Rob Klose

Emilia Dimitrova @edimitrova.bsky.social · 8d

If you are a computational biologist interested in how chromatin states are established and maintained to regulate transcription, this is the dream job for you! This will be in close collaboration with the Klose lab in Oxford and we have a lot of cool projects you can get involved in. Apply!

John Innes Centre @johninnescentre.bsky.social · 8d

VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system.

www.jic.ac.uk/vacancies/po...

Closing date - 9 November 2025
Salary - £37,500 - £45,350
Contract - 36 months, full-time

Postdoctoral Researcher (Howard Group) | John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.

www.jic.ac.uk

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Reposted by Rob Klose

Ander Movilla @andermovilla.bsky.social · 7d

Very exciting opportunity for those with a quantitative background and interested in epigenetics / gene regulation. Highly collaborative environment!

John Innes Centre @johninnescentre.bsky.social · 8d

VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system.

www.jic.ac.uk/vacancies/po...

Closing date - 9 November 2025
Salary - £37,500 - £45,350
Contract - 36 months, full-time

Postdoctoral Researcher (Howard Group) | John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.

www.jic.ac.uk

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Rob Klose @robklose.bsky.social · 6d

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!

jobs.jic.ac.uk/Details.asp?...

John Innes Centre

jobs.jic.ac.uk

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Rob Klose @robklose.bsky.social · 6d

Me too!

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Reposted by Rob Klose

Laurence Pearl 🔥 @laurencepearl.bsky.social · 6d

I’m going for NextGen DNA sequencing

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Reposted by Rob Klose

Prachee Avasthi @pracheeac.bsky.social · 7d

Some scientists aren’t waiting for journals to catch up. They’re showing us what’s next.

The Beyond the Journal awards honor those breaking the mold in how science is shared.

More details: pracheeac.substack.com/p/off-roadin...

Nominate or self-nominate here: www.experiment.foundation/beyond

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