The first-in-human study of anti-BCMA CAR-T therapy for progressive multiple sclerosis shows a favorable safety profile, depletion of plasma cells in the central nervous system, and alleviation of mic...

CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in.

Scientists have identified an unusual type of brain cell that may play a vital role in progressive multiple sclerosis (MS), likely contributing to the persistent inflammation characteristic of the dis...

Explore the latest findings on MS and a unique brain cell that may influence progressive multiple sclerosis and inflammation.

Researchers have identified a strange, malfunctioning brain cell that reverts to a developmental state while aging prematurely, fueling the chronic inflammation that defines this debilitating disease....

Tissue structure, the organization of cells, vasculature and extracellular matrix, determines organ function. Yet how tissue structure changes with aging remains largely unknown. Current aging researc...

High-purity dopaminergic progenitors were generated from human embryonic stem cells, and their safety and exploratory efficacy were evaluated in a single-center, open-label, dose-escalation phase 1/2a...

imageimageGlia activation, inflammation, cell death pathways and neuronal pathologies are associated with disease progression in preclinical AD. Activation of glia cells and cell death pathways mainta...

Scientists have identified an unusual type of brain cell that may play a vital role in progressive multiple sclerosis (MS), likely contributing to the persistent inflammation characteristic of the dis...

“Disease in a dish” study indicates DARG cells may be contribute to persistent inflammation characteristic of progressive MS.

Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

Park, Nicaise, Tsitsipatis, and colleagues discover transcriptional and epigenetic markers in human PMS iNSCs and fibroblasts that may underlie their senescent and inflammatory state. Novel DARGs with...

Amouzgar and colleagues present a deep, single-cell mass cytometry approach to capture canonical and noncanonical cell cycle states using protein, phospho-protein, and DNA labelling measurements for high-throughput, multiplexed cell cycle quantification.

Li et al. engineered neural stem cell-derived extracellular vesicles carrying a modified Wnt7a ligand to target the blood-brain barrier (BBB). These vesicl

Defining the spatial organization of tissues and organs like the brain from large datasets is a major challenge. Here, authors introduce CellTransformer, an AI tool that defines spatial domains in the mouse brain based on spatial transcriptomics, a technology that measures which genes are active in different parts of tissue.

Aging is a complex process resulting in a decline in organ function. Here the authors proposes that chronic activation of tissue damage response mechanisms drives aging, with aged organs displaying features similar to those seen after acute injury. This provides a unifying framework for understanding the aging process and suggests new directions for treating age-related diseases.

The MS-STAT2 trial did not show a treatment effect of simvastatin in slowing disability progression in SPMS. Simvastatin use in multiple sclerosis should be confined to existing vascular indications.

SV2A-PET reveals cortical synapse loss in multiple sclerosis (MS), highlighting a potential approach for unmasking gray matter pathology.

Márquez-Valadez and colleagues show that neuropsychiatric disorders alter the generation of new neurons in the adult human brain. Major depression, schizophrenia, and bipolar disorder disrupt early st...

Walsh et al. establish a human forebrain assembloid protocol that supports the derivation of bona fide PVALB+ cortical interneurons and employ it to model schizophrenia in disease-associated structura...

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.

The human brain develops and matures over an exceptionally prolonged period of time that spans nearly two decades of life. Processes that govern species-specific aspects of human postnatal brain devel...

Aging drives distinct molecular changes in the brain. Here, the authors use scRNAseq and MERFISH and find that in mice, aging induces subtype-specific, regionally biased changes in striatal astrocytes, marked by transcriptional repression, inflammation, and impaired neuronal interactions.

The homeostatic link between the production of mitochondrial ROS (mtROS) and mitophagy plays a significant role in how cells respond to various phy...