Pharmacy Phun Quiz
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Pharmacy Phun Quiz
@pharmacyphunquiz.bsky.social
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Pharmacy Phun Quiz is doses of Pharmacy knowledge presented in quiz form—for pharmacists or anyone with an interest in pharmacy, medicines, and healthcare.
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PharmacyPhunQuiz is not medical advice—it is pharmacy and healthcare-centered educational entertainment. Information comes from reputable sites, accounts, and advocacy groups. Anything remotely controversial is credited to the source. PhunQuiz does not post opinions. This is a Pharmacy stan account.
Answer: D. Direct oral anticoagulants, hypertriglyceridemia, and hyperbilirubinemia may interfere with factor Xa inhibitor levels. However, Lupus may lead to elevated baseline pTT, thus PTT monitoring may lead to inaccurate representation of anticoagulation. Credit: @accpcardprn on X.
In which scenario is utilizing a factor Xa inhibitor instead of a Partial Thromboplastin Time (PTT)-driven heparin protocol appropriate?

When a patient has…

A. Afib on rivaroxaban at home
B. Hyperbilirubinemia
C. Hypertriglyceridemia
D. Lupus erythematosus

The answer is in the thread
Answer: A, 5.7-6.0%. A hemoglobin A1c measurement of 6.4% is not awful, but it is an indicator of prediabetes. 6.5% or above is an indication of diabetes or lack of glycemic control in a known diabetic. >7% is not good. Two decades ago, 7% was considered normal.
Know your diabetes numbers? Hemoglobin A1c is the percentage of glycosylated hemoglobin. It is an indicator of blood glucose levels over 2-3 months. Which is a good result for a hemoglobin A1c test?

A. 5.7-6% 
B. 6-6.5%
C. 6.5-7%
D. 7% or higher

The answer is in the thread
Answer: D. Rest and supportive care are recommended for HAV, a self-limiting disease. If hepatitis A is severe enough, hospitalization may be required. IM immune globulin can be used.
What is the recommended treatment for hepatitis A?

A. Adefovir or lamivudine
B. Dexamethasone
C. Fidaxomicin or vancomycin
D. Supportive care

The answer is in the thread #PhunQuiz
Answer: D. Prodrug tamoxifen requires CYP2D6 activation for effectiveness. Paroxetine inhibits CYP2D6. This interaction blocking the conversion of tamoxifen to its active metabolite, endoxifen, reduces the efficacy of tamoxifen, increasing the risk of breast cancer occurrence.
Jane is a breast cancer survivor. She takes tamoxifen to prevent a recurrence. Which one of her medications interacts with tamoxifen and could lead to a cancer recurrence?

A. Clonazepam
B. Levothyroxine
C. Lisinopril
D. Paroxetine

The answer is in the thread
#PhunQuiz
Answer: B. Golimumab (Simponi, Simponi Aria) is the missing TNF-alfa inhibitor. Anakinra is an IL-1 antagonist; natalizumab is an anti-α4-integrin antibody; rilonacept is an interleukin antagonist. All of them modify the immune system, but only golimumab is a TNF-alfa inhibitor.
There are currently five approved Tumor Necrosis Factor (TNF)-alfa inhibitors: Adalimumab, certolizumab, etanercept, and infliximab. Which is the missing one?

A. Anakinra
B. Golimumab
C. Natalizumab
D. Rilonacept

The answer is in the thread #PhunQuiz
Answer: D. Phenylephrine is an alpha-adrenergic agonist, a vasoconstrictor–orally it is not effective, but intranasally it relieves nasal congestion due to cold or allergy. The ophthalmic preparations relieve redness. It is administered IV for hypotension due to anesthesia.
Take this #PhunQuiz Dose. Which one is effective topically for a stuffy nose?

A. Phenelzine
B. Phentermine
C. Phentolamine
D. Phenylephrine

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The answer is C, respiratory depression. Overdose of sedative/hypnotics can cause coma and fatal central respiratory arrest. Credit qbankusmle.com.
Which is the most likely cause of death in cases of overdose of sedative/hypnotics?

A. Cerebral edema
B. Hypothermia
C. Respiratory depression
D. Status epilepticus

The answer is in the thread #PhunQuiz
The answer is B, benazepril. All ACE inhibitors may cause angioedema. Although on average the incidence is less than 1%, it occurs 5 times more often in patients of African descent.
Which antihypertensive agent may precipitate angioedema?

A. Amlodipine
B. Benazepril
C. Losartan
D. Sotalol

The answer is in the thread
The answer is C, both. ACEIs (lisinopril), ARBs, and potassium-sparing diuretics (amiloride) tend to cause hyperkalemia. Ringer’s lactate solution should be avoided in these patients if possible.
Lactated Ringer’s solution contains potassium and should be given cautiously to patients taking drugs that tend to cause hyperkalemia. Ringer’s solution should be avoided in patients taking which one?

A. Amiloride
B. Lisinopril
C. Both
D. Neither

The answer follows
#PhunQuiz
Bits and Pieces:

Preteens and teens are at increased risk of certain vaccine-preventable diseases (meningococcal, Tdap) as they engage in common activities such as sharing drinks and kissing, etc. CDC recommends the HPV vaccine before teens become sexually active. #PhunQuiz
The answer is C. Imipenem + cilastatin (Primaxin) is the only one of these options that penetrates the BBB and is eventually effective against BLP organisms. Source: qbankusmle.com. Incidentally, ticarcillin is not available in the US.
Which antibiotic (of these listed) is effective against beta-lactamase-producing (BLP) organisms and can penetrate the blood brain barrier (BBB)?

A. Amoxicillin
B. Cefazolin
C. Imipenem + cilastatin
D. Ticarcillin

The answer is in the thread #PhunQuiz
The answers are B, 1, and 3. Aclidinium (Long-Acting Muscarinic Antagonist) + formoterol (Long-Acting Beta-2 Agonist) is a bronchodilator combination used for COPD. It is NOT indicated for asthma or acute bronchospasm.
This is a #PhunQuiz Quickie for aclidinium + formoterol inhalation (Duaklir). What is aclidinium? 

A. Long-acting beta-2 agonist (LABA) 
B. Long-acting muscarinic antagonist (LAMA)

What is formoterol?

1. LABA
2. LAMA

Indication/s?

a. Asthma
b. Asthma, COPD
c. COPD

The answer is in the thread
The answer is D, sucralfate. Because it is so poorly soluble, sucralfate polymerizes in acid and binds to ulcerated tissues and protects them from pepsin and gastric acid. Credit qbankusmle.com.
Which medication protects ulcerated gastric tissue from further damage by gastric enzymes and acid through polymerization?

A. Cimetidine
B. Famotidine
C. Omeprazole
D. Sucralfate

The answer is in the thread #PhunQuiz