MrVI, based on deep generative modelling, is a unified framework for integrative, exploratory and comparative analyses of large-scale (multi-sample) single-cell RNA-seq datasets.

With a trained SCVI model you can perform differential expression analysis to learn which genes are increased and decreased in gene expression as cells change their states.

GPR25 and its ligand define the core chemoaffinity axis GPR25–CXCL17 of the integrated extraintestinal mucosal immune system, regulating how immune responses disseminate to non-intestinal barrier tissues and with implications for understanding and manipulating immunity and inflammation.

Here, the authors use single-cell spatial transcriptomics to profile the airway wall landscape in health and during asthma. Discrete proinflammatory ecosystems containing alarmins, chemokines and a unique combination of stromal cells were identified in healthy individuals, and these were spatially dysregulated in asthma.

Time is special.

I wanted to speed up negative binomial regression with a novel transformer model, but it actually turns out that a classical method of moments is a better solution.

In this Review, Kato and Kita discuss the complex interactions between airway epithelial cells and immune cells that contribute to the development of asthma and chronic rhinosinusitis. They highlight ...

When the mysterious deep space research vessel USCSS Maginot crash-lands on Earth, Wendy and a ragtag group of tactical soldiers make a fateful discovery that puts them face-to-face with the planet's ...

I. Suppose I were to come out tomorrow as gay. I have amazing and wonderful friends, and I certainly wouldn’t expect them to hate me forever or tell me to burn in Hell or anything like that. …

Pour-over coffee has long been popular with coffee enthusiasts, but it frustrated coffee shops because it takes so long to make. That’s changing.

There are at least 10,000 known monogenic diseases. When attempting to cure them, how do clinicians decide which gene-therapy delivery method is best?

How a Swiss pharma giant built the last great corporate research skunkworks - and why that model may never work again.

Cell and gene therapies are treating previously untreatable diseases and saving tens of thousands of lives. So why are companies shutting down?

In this Review, the authors update us on the immunology and clinical options for treating asthma.

Horses bled for antivenom, crabs drained for endotoxin tests, and silkworms boiled for silk. Science can now replace these practices with synthetic alternatives — but we need to find ways to scale the...

In recent years, there has been an explosion of interest in stem cells, not just within the scientific and medical communities but also among politicians, religious groups and ethicists. Here, we summ...

Personal site for posts about my interests: the biotech industry, medicine, molecular biology, neuroscience, biorisk, science, consciousness, AI, innovation, decision making, philosophy, games, sci-fi...

Negative binomial regression is essential for analyzing over-dispersed count data in in comparative studies, but parameter estimation becomes computationally challenging in large screens requiring mil...