If you're interested in computational psychiatry, come chat with me about the neurochemical markers of uncertainty processing at poster A10 #BAP2025

Exciting guest lecture by Angela Roberts on anhedonia and anxiety #BAP2025

Thrilled that this work from my PhD and postdoc is finally out in preprint form. It’s been several years in the making and I couldn’t be more grateful for such an amazing team of collaborators to help bring it to the finish line!

We also looked at the above in relation to trait anxiety. Interestingly, both model-free and model-based results indicate that that high trait anxiety was associated with faster responses after the reversal (4/4)

We found that baseline glutamine+glutamate levels in the primary motor cortex M1 correlate with model-based prediction errors & volatility beliefs, suggesting a key neural marker for uncertainty processing (3/4)

To probe the underlying processes, we introduce a novel categorical state-transition extension of the Hierarchical Gaussian Filter (HGF) that tracks beliefs about stimulus transitions in a 4-choice probabilistic serial reaction time reversal learning task. (2/4)

New preprint alert! How do we process uncertainty, and how do neurometabolites shape this?🧠Here we combine computational modeling + 7T MRS to answer these questions: www.biorxiv.org/content/10.1...
With Peter Thestrup Waade, Chris Mathys, Frederike Petzchner, @beckyneuro.bsky.social & others! 🧵(1/4)

Hello world beyond Twitter