Nature Reviews Gastroenterology & Hepatology, Published online: 09 October 2025; doi:10.1038/s41575-025-01127-yWNT–β-catenin activation is common in hepatocellular carcinoma (HCC). In this Review, the authors summarize our understanding of the role of WNT–β-catenin activation in HCC — based on results from in vitro and in vivo models — and implications for precision treatment of HCC via targeting β-catenin.

Nature Reviews Gastroenterology & Hepatology, Published online: 13 October 2025; doi:10.1038/s41575-025-01114-3This Roadmap presents and outlines the creation of the Human Liver Cell Atlas as a reference map and resource for the liver community, providing an overview of the steps needed to build the atlas, as well as outlining the major challenges and potential of this venture.

Nature Reviews Gastroenterology & Hepatology, Published online: 13 October 2025; doi:10.1038/s41575-025-01114-3This Roadmap presents and outlines the creation of the Human Liver Cell Atlas as a reference map and resource for the liver community, providing an overview of the steps needed to build the atlas, as well as outlining the major challenges and potential of this venture.

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01130-3Submucosal endoscopy creates a new space to implant bioelectronics in a ‘scarless’ way, establishing a reliable interface between device and tissue that remains stable for months in the gastrointestinal tract. Submucosal bioelectronics, combining diagnostic and therapeutic functions, hold great promise as powerful tools to advance both fundamental understanding and clinical management of gastrointestinal disease.

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01137-wAspirin and recurrence of PI3K-mutated CRC

Nature Reviews Gastroenterology & Hepatology, Published online: 10 October 2025; doi:10.1038/s41575-025-01116-1Advances in organoid culture have enabled the modelling of many aspects of organs in vitro, transforming experimental biology. This Review provides a comprehensive overview of the current and emerging liver and pancreas organoid technologies and discusses current limitations and future directions.

Nature Reviews Gastroenterology & Hepatology, Published online: 10 October 2025; doi:10.1038/s41575-025-01135-yAfter the regulatory rejection of obeticholic acid, peroxisome proliferator-activated receptor (PPAR) agonists have emerged as the leading second-line candidates for primary biliary cholangitis, pending definitive approval. Of these, only bezafibrate — a low-cost, widely available generic — has demonstrated long-term efficacy, a fact largely disregarded.

Nature Reviews Gastroenterology & Hepatology, Published online: 10 October 2025; doi:10.1038/s41575-025-01116-1Advances in organoid culture have enabled the modelling of many aspects of organs in vitro, transforming experimental biology. This Review provides a comprehensive overview of the current and emerging liver and pancreas organoid technologies and discusses current limitations and future directions.

Nature Reviews Gastroenterology & Hepatology, Published online: 10 October 2025; doi:10.1038/s41575-025-01135-yAfter the regulatory rejection of obeticholic acid, peroxisome proliferator-activated receptor (PPAR) agonists have emerged as the leading second-line candidates for primary biliary cholangitis, pending definitive approval. Of these, only bezafibrate — a low-cost, widely available generic — has demonstrated long-term efficacy, a fact largely disregarded.

Nature Reviews Gastroenterology & Hepatology, Published online: 09 October 2025; doi:10.1038/s41575-025-01127-yWNT–β-catenin activation is common in hepatocellular carcinoma (HCC). In this Review, the authors summarize our understanding of the role of WNT–β-catenin activation in HCC — based on results from in vitro and in vivo models — and implications for precision treatment of HCC via targeting β-catenin.

Nature Reviews Gastroenterology & Hepatology, Published online: 09 October 2025; doi:10.1038/s41575-025-01127-yWNT–β-catenin activation is common in hepatocellular carcinoma (HCC). In this Review, the authors summarize our understanding of the role of WNT–β-catenin activation in HCC — based on results from in vitro and in vivo models — and implications for precision treatment of HCC via targeting β-catenin.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01137-wAspirin and recurrence of PI3K-mutated CRC

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01136-xNivolumab and ipilimumab as neoadjuvant therapy for potentially resectable HCC

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01130-3Submucosal endoscopy creates a new space to implant bioelectronics in a ‘scarless’ way, establishing a reliable interface between device and tissue that remains stable for months in the gastrointestinal tract. Submucosal bioelectronics, combining diagnostic and therapeutic functions, hold great promise as powerful tools to advance both fundamental understanding and clinical management of gastrointestinal disease.

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01137-wAspirin and recurrence of PI3K-mutated CRC

Nature Reviews Gastroenterology & Hepatology, Published online: 06 October 2025; doi:10.1038/s41575-025-01130-3Submucosal endoscopy creates a new space to implant bioelectronics in a ‘scarless’ way, establishing a reliable interface between device and tissue that remains stable for months in the gastrointestinal tract. Submucosal bioelectronics, combining diagnostic and therapeutic functions, hold great promise as powerful tools to advance both fundamental understanding and clinical management of gastrointestinal disease.

Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2025; doi:10.1038/s41575-025-01131-2Maternal gut microbiome in early pregnancy: predictor of preterm birth?

Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2025; doi:10.1038/s41575-025-01107-2Portal hypertension and systemic inflammation are key factors driving decompensation and organ failure in cirrhosis. This Review examines those two factors and, based on their mechanistic interaction, proposes a new concept of the clinical phenotypes in decompensated cirrhosis.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

Nature Reviews Gastroenterology & Hepatology, Published online: 26 September 2025; doi:10.1038/s41575-025-01120-5Metabolic and alcohol-related liver disease presents challenges in clinical trials due to complex pathophysiology. This Review discusses noninvasive imaging, serum biomarkers and adaptive designs as modalities to enhance patient-centric end points, aiming to refine diagnostics and improve drug development.