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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 1d

Typically, men with Androgenetic #alopecia present with bitemporal frontal hairline recession, vertex thinning, or a combination of both, with the predominant clinical course following the Hamilton–Norwood scale.
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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 1d

Frontotemporal lobar degeneration is one of the most common causes of early-onset dementia and presents with early social–emotional–behavioural and/or language changes that can be accompanied by a pyramidal or extrapyramidal motor disorder.
https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 2d

The hair follicle is the target tissue of androgenetic #alopecia pathogenesis. During active growth, terminal scalp hair follicles are shaped as elongated cylinders, extending from the epidermis into the dermal adipose layer.
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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 5d

Androgen signalling has a central role in androgenetic #alopecia pathogenesis. Unlike its core molecular function, the prominent signalling effect of androgens on the hair growth cycle is distinct to humans and other primates.
https://www.nature.c...

Schematic shows androgen signalling in androgenetic alopecia (AGA)-susceptible scalp hair follicle

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 6d

Get Primed on Androgenetic alopecia with our NEW PrimeView! FREE to download this week! https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 6d

Our NEW Primer on Androgenetic alopecia is live today! By Liu, Tosti, Wang, Heilmann-Heimbach, Augh, Jimenez, Lin, Kwon and Plikus. Check it out here: https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 6d

#Listeriosis is a rare but severe food-borne disease that leads to mild gastroenteritis in most adults but can cause severe disease during pregnancy and in immunocompromised individuals https://www.nature.c...

An overview of listeriosis diagnosis, treatment and pathophysiology.

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 7d

Risk factors for chronic kidney disease can be differentiated into those that increase nephron workload and those that reduce their capacity. Preterm birth can result in lifelong reduced kidney capacity. #CKD https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 7d

Management of non-small-cell #lungcancer involves surgery, chemotherapy, radiotherapy, immune checkpoint blockers and tyrosine kinase inhibitors, the combination and order of which depends on several factors https://www.nature.c...

Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 8d

#Listeriosis manifests primarily as #septicaemia, neurolisteriosis, and maternal–neonatal infections, each with distinct prevalence and mortality rates https://www.nature.c...

A Figure showing the prevalence and outcomes of different clinical forms of listeriosis.

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 9d

#Listeria monocytogenes uses surface proteins InlA and InlB to activate PI3Kα for cell entry and survival, facilitating invasion of goblet cells, syncytiotrophoblasts, and inflammatory monocytes https://www.nature.c...

A Figure showing the molecular mechanisms of L. monocytogenes cell invasion and survival,

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 9d

The ABCDE system assists in assessing pigmented lesions and includes asymmetry (A), border irregularity (B), colour variation (C), diameter (D) greater than 6 mm, and elevation or evolution (E) or timing of lesion growth. #melanoma https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 10d

#Listeria monocytogenes crosses the intestinal barrier via goblet and M cells, the placental barrier through syncytiotrophoblasts, and the blood–brain barrier by spreading from infected monocytes to endothelial cells https://www.nature.c...

Schematics showing how Listeria monocytogenes crosses host barriers.

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 10d

Mycobacterium leprae has a long division rate of up to 14 days and cannot be cultured in vitro; most knowledge of the composition and structure of its cell wall is derived from other, culturable, mycobacteria. #leprosy https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 11d

#Listeria monocytogenes causes serious infections by invading cells and crossing intestinal, blood–brain, and placental barriers, leading to #bacteraemia, CNS, and maternal–neonatal complications https://www.nature.c...

Schematics showing the mechanisms of Listeria monocytogenes infection and dissemination.

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 11d

Regenerative medicine aims to restore or replace damaged tissues and organs, and is emerging as a potential solution for various #liverdiseases including biliary atresia https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 12d

Several cortical regions (lateral view) of the brain are implicated in attention-deficit/hyperactivity disorder (#ADHD) https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 12d

#Listeriosis is primarily caused by eating contaminated food and the ability of L. monocytogenes to grow at a wide range of temperatures and tolerate harsh conditions explains its ubiquitousness in the environment https://www.nature.c...

A map showing the estimated global burden of listeriosis.

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 13d

Get Primed on Listeriosis with our NEW PrimeView! FREE to download this week! https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 13d

Our NEW Primer on Listeriosis is live today! By Disson, Charlier, Pérot, Leclercq, @nirpaz.bsky.social, Kathariou, Tsai & Lecuit. Check it out here: https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 14d

Lupus nephritis is a type of immune-mediated glomerulonephritis and a serious complication of systemic lupus erythematosus that can affect up to 60% of patients with this condition.
https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 14d

Urticaria is an inflammatory skin disorder presenting with wheals, angioedema or both due to activation and degranulation of skin mast cells and the release of histamine and other mediators.
https://www.nature.c... #UDAY and #UrticariaDay2025

Urticaria - Nature Reviews Disease Primers

This PrimeView highlights the mechanisms or urticaria and summarizes its epidemiology, diagnosis and management. It accompanies the Primer on this topic by Kolkhir and colleagues.

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 15d

Anatomic locations of ectopic pregnancy (EP), comprising extrauterine EP (tubal EP), ovarian EP and abdominal EP and uterine EP. Of note, abdominal EP may be implantation anywhere in the abdomen.
https://www.nature.c...

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 15d

Comorbid conditions of lupus nephritis and adverse events associated with its treatment, for example infections, cardiovascular issues, and osteoporosis, require active management according to guidelines.
https://www.nature.c...

An overview of the management of comorbidities and treatment adverse effects In lupus nephritis.

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 16d

Heart failure with preserved ejection fraction accounts for nearly half of all heart failure cases with a rising prevalence in growing ageing population. Risk factors include age, diabetes, hypertension, obesity+atrial fibrillation.
https://www.nature.c... #worldheartday

Heart failure with preserved ejection fraction - Nature Reviews Disease Primers

This PrimeView highlights the management of heart failure with preserved ejection fraction, and summarizes the epidemiology, mechanisms, diagnosis, and quality of life of this disorder. It accompanies the Primer article on this topic by Hamo et al.

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